
    ***    Cheatsheet for bear setup     ***
    
    Methods                           setting     
    ------------------------------------------    
    run demo                     no(0),yes(1).    
 
    study design           2x2x2 crossover(0),    
                                 replicate(1),    
                                  parallel(2).    
                                                  
    single-/multiple-dose      single-dose(0),    
                             multiple-dose(1).    
                                                  
    lambda_z estimation                           
     Adjusted R sq. (ARS).................(0),    
     Akaike information criterion (AIC)...(1),    
     Two-Times-Tmax(TTT)..................(2),    
     TTT and ARS..........................(3),    
     TTT and AIC..........................(4),    
     Select 2-6 data points manually......(5),     
     Load previous selection (.RData).....(6).    
                                                  
    trapezoidal AUC     linear-up/log-down(0),    
                                all linear(1).    
                                                  
    BE criterion lower limit (LL as %).... 80     
     upper limit (UL) = 1/LL.                                                             
                                                  
    ODA (outlier detection analysis)    no(0),    
                                       yes(1).    
                                                  
   ------------------------------------------     
   (1) User can change these settings from the    
       top menu. Select [# Edit the setup files]  
       from the top menu and then scroll up this  
       terminal to see more.                      
   (2) All these settings are not completely      
       applied when running with demo dataset.    
   (3) *** WARNING: Be careful to set up correct  
       methods; otherwise it may cause bear       
       crashed accidentally.                      
   ------------------------------------------ 
   -------------- partial AUC  --------------       
    pAUC: use truncated or partial AUC?             
      (0 - No, else - Yes)                          
    pAUC_start: the starting time of pAUC           
    pAUC_end: the end time of pAUC                  
      'pAUC_start' and 'pAUC_end' will be 
      ignored if pAUC is disabled (= 0).                    
    'pAUC_start' must be less than 'pAUC_end'.      
    ------------------------------------------      
    
           
   Methods                           setting        
   ------------------------------------------       
   IndivDP_output               no(0), yes(1)       
                                                 
   ------------ Indiv. DP output  -----------      
     IndivDP_output: (no(0), yes(1))                
     to enable this function, the original          
     dataset is required same sampling times        
     for each subject; time zero needs to be        
     input as '0'; and if there is any missing      
     data or conc. which is BLQ MUST be input       
     as 'NA' (not to be deleted).
                        
   ***                                              
     IDP output: individual data point output       
     as .csv files. WARNING: do not use this        
     function if you have irregular sampling        
     time (such as using real times) for each       
     subject.                                       
   ------------------------------------------    
    
   ----------- multiple-dose only -----------       
   *Tlast: the time of the last dose given for      
    the multiple-dose study; will be ignored        
    when it is a single-dose study; same as         
    Dosing interval.                                
   ------------------------------------------       
     Drug conc. in plasma/serum                      
      (mcg/mL, ng/mL, pg/mL)     mcg/mL(0),          
                                  ng/mL(1),
                                  pg/mL(2).
                                                     
     Metabolite                  no(0), yes(1)
     
     x-axis                      label of x-axis
     y-axis                      label of y-axis
                                (no conc. unit req.)
     
     **Dose must be input as the unit of mg.             
   ------------------------------------------     
     
     
    
    
    
                                                 
                                                 
                                                 
                                                 
                                                 
                                                 
                                                 
                                                 
                                                 
                                                 
                                                 