\HeaderA{boot2fuzzy}{function to write MapleTree files for viewing bootstrap estimated cluster membership probabilities based on hopach clustering results}{boot2fuzzy}
\keyword{cluster}{boot2fuzzy}
\keyword{nonparametric}{boot2fuzzy}
\keyword{multivariate}{boot2fuzzy}
\begin{Description}\relax
The MapleTree software (http://mapletree.sourceforge.net/) is an open source, cross-platform, visualization tool to graphically browse results of cluster analyses. The \code{boot2fuzzy} function takes a data matrix, plus corresponding \code{hopach} clustering output and bootstrap resampling output, and writes the (.cdt, .fct, and .mb) files needed to view these "fuzzy clustering" results in MapleTree.
\end{Description}
\begin{Usage}
\begin{verbatim}
boot2fuzzy(data, bootobj, hopach.genes, hopach.arrays = NULL, 
file="hopach", clust.wts = NULL, gene.wts = NULL, array.wts = NULL, 
gene.names = NULL)
\end{verbatim}
\end{Usage}
\begin{Arguments}
\begin{ldescription}
\item[\code{data}] data matrix, data frame or exprSet of gene expression measurements. Each column corresponds to an array, and each row corresponds to a gene. All values must be numeric. Missing values are ignored.
\item[\code{bootobj}] output of \code{boothopach} or \code{bootmedoids} applied to the genes - a matrix of bootstrap estimated cluster membership probabilities, with a row for each row in \code{data} and a column for each cluster.
\item[\code{hopach.genes}] output of the \code{hopach} function applied to genes (rows of \code{data}.
\item[\code{hopach.arrays}] optional output of the \code{hopach} function applied to arrays (columns of \code{data}.
\item[\code{file}] name for the output files (the extensions .cdt, .mb and .fct will be added).
\item[\code{clust.wts}] an optional vector of numeric weights for the clusters.
\item[\code{gene.wts}] an optional vector of numeric weights for the genes.
\item[\code{array.wts}] an optional vector of numeric weights for the arrays.
\item[\code{gene.names}] optional vector of names or annotations for the genes, which can be different from the row names of \code{data}
\end{ldescription}
\end{Arguments}
\begin{Value}
The function \code{boot2fuzzy} has no value. It writes three text files to the current working directory.
\end{Value}
\begin{Note}\relax
Thank you to Lisa Simirenko <lsimirenko@lbl.gov> for providing HOPACH views in MapleTree, and to Karen Vranizan <vranizan@uclink.berkeley.edu> for her input. The MapleTree software can be downloaded from: http://sourceforge.net/projects/mapletree/
\end{Note}
\begin{Author}\relax
Katherine S. Pollard <kpollard@gladstone.ucsf.edu>
\end{Author}
\begin{References}\relax
van der Laan, M.J. and Pollard, K.S. A new algorithm for hybrid hierarchical clustering with visualization and the bootstrap. Journal of Statistical Planning and Inference, 2003, 117, pp. 275-303.

\url{http://www.stat.berkeley.edu/~laan/Research/Research_subpages/Papers/hopach.pdf}
\end{References}
\begin{SeeAlso}\relax
\code{\LinkA{hopach}{hopach}}, \code{\LinkA{boothopach}{boothopach}}, \code{\LinkA{bootmedoids}{bootmedoids}}, \code{\LinkA{hopach2tree}{hopach2tree}}
\end{SeeAlso}
\begin{Examples}
\begin{ExampleCode}

#25 variables from two groups with 3 observations per variable
mydata<-rbind(cbind(rnorm(10,0,0.5),rnorm(10,0,0.5),rnorm(10,0,0.5)),cbind(rnorm(15,5,0.5),rnorm(15,5,0.5),rnorm(15,5,0.5)))
dimnames(mydata)<-list(paste("Var",1:25,sep=""),paste("Exp",1:3,sep=""))
mydist<-distancematrix(mydata,d="cosangle") #compute the distance matrix.

#clusters and final tree
clustresult<-hopach(mydata,dmat=mydist)

#bootstrap resampling
myobj<-boothopach(mydata,clustresult)

#write MapleTree files
boot2fuzzy(mydata,myobj,clustresult)

\end{ExampleCode}
\end{Examples}

