inNucleus {y2hStat} | R Documentation

## A function to determine those proteins annotated by the nucleus GO term.

### Description

This function takes the experimental y2h data as well as an estimate for an in silico interactome (ISI) and determines which protein complexes of the ISI has more than 75 percent of the constituent member proteins annotated by the nucleus GO term.

### Usage

    inNucleus(y2h, ISI = NULL)

### Arguments

`y2h` | A three tiered list. Names of the second tier corresponds to ID of experiment. Names of the third tier should be the bait proteins. The entries of the third tier are character vectors of proteins detected as prey
`ISI` | The incidence matrix of the bi-partite graph representation of the in silico interactome.

### Value

`nucProt` | A character vector of those proteins annotated to the nucleus
`nucComp` | An incidence matrix of the bipartite graph representation of the ISI with the restriction that only complexes with 75 percent of its constituent members are annnotated by the nucleus term.
`nuclearY2H` | A data structure exactly like the input y2h, except that the prey proteins are restricted to those which are annotated by the nucleus term

### Author(s)

T Chiang

### Examples

    data(y2hSysGW)
    eg=y2hSysGW[3]
    inNucleus(eg)

[Package y2hStat version 1.2.0 Index]