expval {twilight} | R Documentation

## Example of twilight.pval result

### Description

Application of function twilight.pval on leukemia data set of Golub et al. (1999), as given in `data(golubMerge)` in `library(golubEsets)`.

First step was the variance-stabilizing normalization of Huber et al. (2002) in `library(vsn)`: `golubNorm <- vsn(exprs(golubMerge))`.

The function call was then `expval <- twilight.pval(golubNorm,id)` with `id <- as.numeric(golubMerge$ALL.AML)`.

### Usage

    data(expval)

### Format

A twilight object.

### References

Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, Bloomfield CD and Lander ES (1999): Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring, Science 286, 531–537.

Huber W, von Heydebreck A, Sültmann H, Poustka A and Vingron M (2002): Variance stabilization applied to microarray data calibration and to the quantification of differential expression, Bioinformatics 18, suppl. 1, S96–S104.

[Package twilight version 1.1.0 Index]