# StAM-Report on Model Fit

## Information on Model Fit

## Performance vs. redundancy

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| Best Delta | Root Error Rate | Performance | Redundancy | #Nodes | #Genes
--- | --- | --- | --- | --- | --- | ---
0 | 0 | 0.0263 | 0.6563 | 0.8534 | 267 | 5437
0.1 | 0.1458 | 0.0263 | 0.5556 | 0.8966 | 215 | 5402
0.2 | 0.4374 | 0.0263 | 0.3976 | 1.1956 | 83 | 5160
0.3 | 0.4374 | 0.0263 | 0.3976 | 1.1956 | 83 | 5160
0.4 | 0.5832 | 0.0263 | 0.307 | 1.7513 | 46 | 4557
0.5 | 0.7289 | 0.0263 | 0.2464 | 2.235 | 40 | 4495
0.6 | 0.7289 | 0.0263 | 0.2464 | 2.235 | 40 | 4495
0.7 | 1.1663 | 0 | 0.0746 | 5.5309 | 12 | 1072
0.8 | 1.1663 | 0 | 0.0746 | 5.5309 | 12 | 1072
0.9 | 1.1663 | 0 | 0.0746 | 5.5309 | 12 | 1072
1 | 1.1663 | 0 | 0.0746 | 5.5309 | 12 | 1072

## Fit for D = 0.7289

Number of classes: | 2
Class weights: | 'ALL': 0.632 'AML': 0.368
Class prior: | 'ALL':0.632 'AML':0.368
Chosen shrinkage level: | 0.729 (by accepting the system default (after consulting weighting alternatives) )
Number of nodes left | 40
Number of accessible genes | 4495

### Shrunken prediction graph

Hover over a node to see its description, click on it to view its detailed results.

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### Nodewise evaluation

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## Details and Performance of GO-nodes

## GO:0005575 | ## cellular_component | Cellular Component

### Parent node

GO:0003673 | Gene_Ontology (not in fit)

### 5 child nodes

ID | Term | Weight
--- | --- | ---
GO:0005623 | cell | 0.60032
GO:0008372 | cellular_component unknown | 0.1568
GO:0005576 | extracellular | 0.24288
GO:0005941 | unlocalized | 0.00000
GO:0019013 | viral nucleocapsid | 0.00000

### Performance on training data

- Error rate: 0
- Performance: 0.24638
- Redundancy: 1.90782

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 1
AML | 1 | 1

## GO:0005576 | ## extracellular | Cellular Component

### Parent node

GO:0005575 | cellular_component

### 3 child nodes

ID | Term | Weight
--- | --- | ---
GO:0005578 | extracellular matrix | 0.58164
GO:0005615 | extracellular space | 0.41836
GO:0005576 | extracellular | 0.00000

### Performance on training data

- Error rate: 0.05263
- Performance: 0.40468
- Redundancy: 1.94924

| Sensitivity | Specificity
--- | --- | ---
ALL | 0.91667 | 1
AML | 1 | 0.91667

## GO:0005615 | ## extracellular space | Cellular Component

### Parent node

GO:0005576 | extracellular

### 6 child nodes

ID | Term | Weight
--- | --- | ---
GO:0042627 | chylomicron | 0.00000
GO:0005602 | complement component C1q complex | 0.00000
GO:0005603 | complement component C2 complex | 0.00000
GO:0005577 | fibrinogen complex | 0.00000
GO:0043033 | isoamylase complex | 0.00000
GO:0005615a | extracellular space (annotated genes) | 1

### Performance on training data

- Error rate: 0.07895
- Performance: 0.4396
- Redundancy: 1.92044

| Sensitivity | Specificity
--- | --- | ---
ALL | 0.91667 | 0.92857
AML | 0.92857 | 0.91667

## GO:0005615 | ## extracellular space (annotated genes) | Cellular Component

### Parent node

GO:0005615 | extracellular space

### This leaf node contains 256 genes

### Performance on training data

- Error rate: 0.07895
- Performance: 0.4396
- Redundancy: 1.92044

| Sensitivity | Specificity
--- | --- | ---
ALL | 0.91667 | 0.92857
AML | 0.92857 | 0.91667

## GO:0005578 | ## extracellular matrix | Cellular Component

### Parent node

GO:0005576 | extracellular

### 6 child nodes

ID | Term | Weight
--- | --- | ---
GO:0005604 | basement membrane | 0.00000
GO:0005581 | collagen | 0.00000
GO:0005579 | membrane attack complex | 0.00000
GO:0001527 | microfibril | 0.00000
GO:0045202 | synapse | 0.00000
GO:0005578a | extracellular matrix (annotated genes) | 1

### Performance on training data

- Error rate: 0.05263
- Performance: 0.38194
- Redundancy: 2.07337

| Sensitivity | Specificity
--- | --- | ---
ALL | 0.91667 | 1
AML | 1 | 0.91667

## GO:0005578 | ## extracellular matrix (annotated genes) | Cellular Component

### Parent node

GO:0005578 | extracellular matrix

### This leaf node contains 122 genes

### Performance on training data

- Error rate: 0.05263
- Performance: 0.38194
- Redundancy: 2.07337

| Sensitivity | Specificity
--- | --- | ---
ALL | 0.91667 | 1
AML | 1 | 0.91667

## GO:0008372 | ## cellular_component unknown (annotated genes) | Cellular Component

### Parent node

GO:0005575 | cellular_component

### This leaf node contains 218 genes

### Performance on training data

- Error rate: 0.02632
- Performance: 0.46689
- Redundancy: 1.44781

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 0.92857
AML | 0.92857 | 1

## GO:0005623 | ## cell | Cellular Component

### Parent node

GO:0005575 | cellular_component

### 9 child nodes

ID | Term | Weight
--- | --- | ---
GO:0005933 | bud | 0.00000
GO:0000267 | cell fraction | 0.38124
GO:0042995 | cell projection | 0.00000
GO:0009986 | cell surface | 0.00000
GO:0005618 | cell wall | 0.00000
GO:0005622 | intracellular | 0.21453
GO:0016020 | membrane | 0.40424
GO:0030427 | site of polarized growth | 0.00000
GO:0005623 | cell | 0.00000

### Performance on training data

- Error rate: 0.02632
- Performance: 0.14563
- Redundancy: 2.24251

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 0.92857
AML | 0.92857 | 1

## GO:0016020 | ## membrane | Cellular Component

### Parent node

GO:0005623 | cell

### 12 child nodes

ID | Term | Weight
--- | --- | ---
GO:0005778 | peroxisomal membrane | 0.00000
GO:0005740 | mitochondrial membrane | 0.00000
GO:0005765 | lysosomal membrane | 0.00000
GO:0009503 | light-harvesting complex (sensu Viridiplantae) | 0.00000
GO:0012505 | endomembrane system | 0.00000
GO:0019898 | extrinsic to membrane | 0.00000
GO:0019866 | inner membrane | 0.00000
GO:0016021 | integral to membrane | 0.59091
GO:0019867 | outer membrane | 0.00000
GO:0005886 | plasma membrane | 0.40909
GO:0045211 | postsynaptic membrane | 0.00000
GO:0016020 | membrane | 0.00000

### Performance on training data

- Error rate: 0.02632
- Performance: 0.10298
- Redundancy: 3.90483

| Sensitivity | Specificity
--- | --- | ---
ALL | 0.95833 | 1
AML | 1 | 0.95833

## GO:0005886 | ## plasma membrane | Cellular Component

### Parent node

GO:0016020 | membrane

### 17 child nodes

ID | Term | Weight
--- | --- | ---
GO:0009897 | external side of plasma membrane | 0.00000
GO:0016010 | dystrophin-associated glycoprotein complex | 0.00000
GO:0019897 | extrinsic to plasma membrane | 0.00000
GO:0005887 | integral to plasma membrane | 0.97707
GO:0016324 | apical plasma membrane | 0.00000
GO:0016327 | apicolateral plasma membrane | 0.00000
GO:0016323 | basolateral plasma membrane | 0.00000
GO:0005903 | brush border | 0.00000
GO:0016599 | caveolar membrane | 0.00000
GO:0030054 | cell junction | 0.00000
GO:0005905 | coated pit | 0.00000
GO:0030175 | filopodium | 0.00000
GO:0001772 | immunological synapse | 0.00000
GO:0030027 | lamellipodium | 0.00000
GO:0005902 | microvillus | 0.00000
GO:0001726 | ruffles | 0.00000
GO:0005886a | plasma membrane (annotated genes) | 0.02293393

### Performance on training data

- Error rate: 0.02632
- Performance: 0.21801
- Redundancy: 3.84312

| Sensitivity | Specificity
--- | --- | ---
ALL | 0.95833 | 1
AML | 1 | 0.95833

## GO:0005886 | ## plasma membrane (annotated genes) | Cellular Component

### Parent node

GO:0005886 | plasma membrane

### This leaf node contains 203 genes

### Performance on training data

- Error rate: 0.07895
- Performance: 0.57841
- Redundancy: 1.54368

| Sensitivity | Specificity
--- | --- | ---
ALL | 0.91667 | 0.92857
AML | 0.92857 | 0.91667

## GO:0016021 | ## integral to membrane | Cellular Component

### Parent node

GO:0016020 | membrane

### 10 child nodes

ID | Term | Weight
--- | --- | ---
GO:0030285 | integral to synaptic vesicle membrane | 0.00000
GO:0030176 | integral to endoplasmic reticulum membrane | 0.00000
GO:0030173 | integral to Golgi membrane | 0.00000
GO:0005639 | integral to nuclear inner membrane | 0.00000
GO:0005887 | integral to plasma membrane | 0.39426
GO:0017071 | intracellular cyclic nucleotide activated cation channel complex | 0.00000
GO:0046696 | lipopolysaccharide receptor complex | 0.00000
GO:0005643 | nuclear pore | 0.00000
GO:0016469 | proton-transporting two-sector ATPase complex | 0.00000
GO:0016021a | integral to membrane (annotated genes) | 0.6057392

### Performance on training data

- Error rate: 0
- Performance: 0.0551
- Redundancy: 4.12857

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 1
AML | 1 | 1

## GO:0016021 | ## integral to membrane (annotated genes) | Cellular Component

### Parent node

GO:0016021 | integral to membrane

### This leaf node contains 817 genes

### Performance on training data

- Error rate: 0
- Performance: 0.00411
- Redundancy: 4.46377

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 1
AML | 1 | 1

## GO:0005887 | ## integral to plasma membrane | Cellular Component

### Parent nodes

GO:0005886 | plasma membrane
GO:0016021 | integral to membrane

### 15 child nodes

ID | Term | Weight
--- | --- | ---
GO:0030526 | granulocyte macrophage colony-stimulating factor receptor complex | 0.00000
GO:0005889 | hydrogen/potassium-exchanging ATPase complex | 0.00000
GO:0008305 | integrin complex | 0.08108
GO:0045323 | interleukin-1 receptor complex | 0.00000
GO:0005898 | interleukin-13 receptor complex | 0.00000
GO:0005895 | interleukin-5 receptor complex | 0.00000
GO:0005896 | interleukin-6 receptor complex | 0.00000
GO:0017146 | N-methyl-D-aspartate selective glutamate receptor complex | 0.00000
GO:0005892 | nicotinic acetylcholine-gated receptor-channel complex | 0.00000
GO:0005900 | oncostatin-M receptor complex | 0.00000
GO:0005890 | sodium/potassium-exchanging ATPase complex | 0.00000
GO:0005891 | voltage-gated calcium channel complex | 0.00000
GO:0008076 | voltage-gated potassium channel complex | 0.00000
GO:0001518 | voltage-gated sodium channel complex | 0.00000
GO:0005887a | integral to plasma membrane (annotated genes) | 0.9189165

### Performance on training data

- Error rate: 0.02632
- Performance: 0.22223
- Redundancy: 4.08089

| Sensitivity | Specificity
--- | --- | ---
ALL | 0.95833 | 1
AML | 1 | 0.95833

## GO:0005887 | ## integral to plasma membrane (annotated genes) | Cellular Component

### Parent node

GO:0005887 | integral to plasma membrane

### This leaf node contains 817 genes

### Performance on training data

- Error rate: 0.02632
- Performance: 0.19715
- Redundancy: 4.47228

| Sensitivity | Specificity
--- | --- | ---
ALL | 0.95833 | 1
AML | 1 | 0.95833

## GO:0008305 | ## integrin complex (annotated genes) | Cellular Component

### Parent node

GO:0005887 | integral to plasma membrane

### This leaf node contains 44 genes

### Performance on training data

- Error rate: 0.05263
- Performance: 0.55289
- Redundancy: 2.47018

| Sensitivity | Specificity
--- | --- | ---
ALL | 0.95833 | 0.92857
AML | 0.92857 | 0.95833

## GO:0005622 | ## intracellular | Cellular Component

### Parent node

GO:0005623 | cell

### 15 child nodes

ID | Term | Weight
--- | --- | ---
GO:0005930 | axoneme | 0.00000
GO:0005929 | cilium | 0.00000
GO:0005938 | cell cortex | 0.09328
GO:0005694 | chromosome | 0.00000
GO:0005737 | cytoplasm | 0.67055
GO:0000178 | exosome (RNase complex) | 0.00000
GO:0005634 | nucleus | 0.06937
GO:0045252 | oxoglutarate dehydrogenase complex | 0.00000
GO:0045259 | proton-transporting ATP synthase complex | 0.00000
GO:0045275 | respiratory chain complex III | 0.00000
GO:0030529 | ribonucleoprotein complex | 0.00000
GO:0030880 | RNA polymerase complex | 0.00000
GO:0009579 | thylakoid | 0.00000
GO:0000151 | ubiquitin ligase complex | 0.00000
GO:0005622a | intracellular (annotated genes) | 0.1667985

### Performance on training data

- Error rate: 0.02632
- Performance: 0.34502
- Redundancy: 1.65423

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 0.92857
AML | 0.92857 | 1

## GO:0005622 | ## intracellular (annotated genes) | Cellular Component

### Parent node

GO:0005622 | intracellular

### This leaf node contains 162 genes

### Performance on training data

- Error rate: 0.10526
- Performance: 0.50179
- Redundancy: 1.71806

| Sensitivity | Specificity
--- | --- | ---
ALL | 0.95833 | 0.78571
AML | 0.78571 | 0.95833

## GO:0005634 | ## nucleus | Cellular Component

### Parent node

GO:0005622 | intracellular

### 16 child nodes

ID | Term | Weight
--- | --- | ---
GO:0000228 | nuclear chromosome | 0.00000
GO:0000502 | proteasome complex (sensu Eukarya) | 0.00000
GO:0000176 | nuclear exosome (RNase complex) | 0.00000
GO:0016533 | cyclin-dependent protein kinase 5 activator complex | 0.00000
GO:0030530 | heterogeneous nuclear ribonucleoprotein complex | 0.00000
GO:0030870 | Mre11 complex | 0.00000
GO:0016363 | nuclear matrix | 0.00000
GO:0005635 | nuclear membrane | 0.00000
GO:0005680 | anaphase-promoting complex | 0.00000
GO:0005730 | nucleolus | 0.00000
GO:0005654 | nucleoplasm | 0.00000
GO:0008180 | signalosome complex | 0.00000
GO:0030532 | small nuclear ribonucleoprotein complex | 0.00000
GO:0005681 | spliceosome complex | 0.00000
GO:0005697 | telomerase holoenzyme complex | 0.00000
GO:0005634a | nucleus (annotated genes) | 1

### Performance on training data

- Error rate: 0.05263
- Performance: 0.55175
- Redundancy: 1.32832

| Sensitivity | Specificity
--- | --- | ---
ALL | 0.95833 | 0.92857
AML | 0.92857 | 0.95833

## GO:0005634 | ## nucleus (annotated genes) | Cellular Component

### Parent node

GO:0005634 | nucleus

### This leaf node contains 1569 genes

### Performance on training data

- Error rate: 0.05263
- Performance: 0.55175
- Redundancy: 1.32832

| Sensitivity | Specificity
--- | --- | ---
ALL | 0.95833 | 0.92857
AML | 0.92857 | 0.95833

## GO:0005737 | ## cytoplasm | Cellular Component

### Parent node

GO:0005622 | intracellular

### 32 child nodes

ID | Term | Weight
--- | --- | ---
GO:0009343 | biotin carboxylase complex | 0.00000
GO:0009346 | citrate lyase complex | 0.00000
GO:0016023 | cytoplasmic vesicle | 0.00000
GO:0005856 | cytoskeleton | 0.28274
GO:0005829 | cytosol | 0.04409
GO:0005659 | delta DNA polymerase complex | 0.00000
GO:0016010 | dystrophin-associated glycoprotein complex | 0.00000
GO:0005783 | endoplasmic reticulum | 0.22383
GO:0005768 | endosome | 0.00000
GO:0016282 | eukaryotic 43S preinitiation complex | 0.00000
GO:0005843 | cytosolic small ribosomal subunit (sensu Eukarya) | 0.00000
GO:0005853 | eukaryotic translation elongation factor 1 complex | 0.00000
GO:0005851 | eukaryotic translation initiation factor 2B complex | 0.00000
GO:0016281 | eukaryotic translation initiation factor 4F complex | 0.00000
GO:0005960 | glycine cleavage complex | 0.00000
GO:0005794 | Golgi apparatus | 0.09535
GO:0005811 | lipid particle | 0.00000
GO:0030117 | membrane coat | 0.00000
GO:0005777 | peroxisome | 0.00000
GO:0005815 | microtubule organizing center | 0.00000
GO:0005739 | mitochondrion | 0.00000
GO:0030484 | muscle fiber | 0.00000
GO:0005854 | nascent polypeptide-associated complex | 0.00000
GO:0048471 | perinuclear region | 0.00000
GO:0009536 | plastid | 0.00000
GO:0045254 | pyruvate dehydrogenase complex | 0.00000
GO:0005840 | ribosome | 0.00000
GO:0016529 | sarcoplasmic reticulum | 0.00000
GO:0005786 | signal recognition particle | 0.00000
GO:0045239 | TCA cycle enzyme complex | 0.00000
GO:0005764 | lysosome | 0.35056
GO:0005737a | cytoplasm (annotated genes) | 0.003428966

### Performance on training data

- Error rate: 0
- Performance: 0.25083
- Redundancy: 1.78558

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 1
AML | 1 | 1

## GO:0005737 | ## cytoplasm (annotated genes) | Cellular Component

### Parent node

GO:0005737 | cytoplasm

### This leaf node contains 499 genes

### Performance on training data

- Error rate: 0.02632
- Performance: 0.58301
- Redundancy: 1.34277

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 0.92857
AML | 0.92857 | 1

## GO:0005764 | ## lysosome | Cellular Component

### 2 parent nodes replaced:

GO:0000323 | lytic vacuole
GO:0005773 | vacuole

### Parent node

GO:0005737 | cytoplasm

### 3 child nodes

ID | Term | Weight
--- | --- | ---
GO:0005765 | lysosomal membrane | 0.00000
GO:0042582 | azurophil granule | 0.00000
GO:0005764a | lysosome (annotated genes) | 1

### Performance on training data

- Error rate: 0
- Performance: 0.14665
- Redundancy: 2.51279

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 1
AML | 1 | 1

## GO:0005764 | ## lysosome (annotated genes) | Cellular Component

### Parent node

GO:0005764 | lysosome

### This leaf node contains 76 genes

### Performance on training data

- Error rate: 0
- Performance: 0.14665
- Redundancy: 2.51279

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 1
AML | 1 | 1

## GO:0005794 | ## Golgi apparatus | Cellular Component

### Parent node

GO:0005737 | cytoplasm

### 8 child nodes

ID | Term | Weight
--- | --- | ---
GO:0005798 | Golgi vesicle | 0.00000
GO:0005801 | Golgi cis-face | 0.00000
GO:0005796 | Golgi lumen | 0.00000
GO:0000139 | Golgi membrane | 0.00000
GO:0005795 | Golgi stack | 0.00000
GO:0005802 | Golgi trans face | 0.00000
GO:0017119 | Golgi transport complex | 0.00000
GO:0005794a | Golgi apparatus (annotated genes) | 1

### Performance on training data

- Error rate: 0.07895
- Performance: 0.46746
- Redundancy: 1.59788

| Sensitivity | Specificity
--- | --- | ---
ALL | 0.91667 | 0.92857
AML | 0.92857 | 0.91667

## GO:0005794 | ## Golgi apparatus (annotated genes) | Cellular Component

### Parent node

GO:0005794 | Golgi apparatus

### This leaf node contains 130 genes

### Performance on training data

- Error rate: 0.07895
- Performance: 0.46746
- Redundancy: 1.59788

| Sensitivity | Specificity
--- | --- | ---
ALL | 0.91667 | 0.92857
AML | 0.92857 | 0.91667

## GO:0005783 | ## endoplasmic reticulum | Cellular Component

### Parent node

GO:0005737 | cytoplasm

### 8 child nodes

ID | Term | Weight
--- | --- | ---
GO:0000502 | proteasome complex (sensu Eukarya) | 0.00000
GO:0005788 | endoplasmic reticulum lumen | 0.00000
GO:0005789 | endoplasmic reticulum membrane | 0.00000
GO:0042825 | TAP complex | 0.00000
GO:0005791 | rough endoplasmic reticulum | 0.00000
GO:0016529 | sarcoplasmic reticulum | 0.00000
GO:0005790 | smooth endoplasmic reticulum | 0.00000
GO:0005783a | endoplasmic reticulum (annotated genes) | 1

### Performance on training data

- Error rate: 0
- Performance: 0.30596
- Redundancy: 1.74099

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 1
AML | 1 | 1

## GO:0005783 | ## endoplasmic reticulum (annotated genes) | Cellular Component

### Parent node

GO:0005783 | endoplasmic reticulum

### This leaf node contains 173 genes

### Performance on training data

- Error rate: 0
- Performance: 0.30596
- Redundancy: 1.74099

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 1
AML | 1 | 1

## GO:0005829 | ## cytosol | Cellular Component

### Parent node

GO:0005737 | cytoplasm

### 9 child nodes

ID | Term | Weight
--- | --- | ---
GO:0005945 | 6-phosphofructokinase complex | 0.00000
GO:0005830 | cytosolic ribosome (sensu Eukarya) | 0.00000
GO:0005833 | hemoglobin complex | 0.00000
GO:0005942 | phosphoinositide 3-kinase complex | 0.00000
GO:0000015 | phosphopyruvate hydratase complex | 0.00000
GO:0016272 | prefoldin complex | 0.00000
GO:0008537 | proteasome activator complex | 0.00000
GO:0000502 | proteasome complex (sensu Eukarya) | 0.00000
GO:0005829a | cytosol (annotated genes) | 1

### Performance on training data

- Error rate: 0.05263
- Performance: 0.5319
- Redundancy: 1.36477

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 0.85714
AML | 0.85714 | 1

## GO:0005829 | ## cytosol (annotated genes) | Cellular Component

### Parent node

GO:0005829 | cytosol

### This leaf node contains 109 genes

### Performance on training data

- Error rate: 0.05263
- Performance: 0.5319
- Redundancy: 1.36477

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 0.85714
AML | 0.85714 | 1

## GO:0005856 | ## cytoskeleton | Cellular Component

### Parent node

GO:0005737 | cytoplasm

### 6 child nodes

ID | Term | Weight
--- | --- | ---
GO:0030864 | cortical actin cytoskeleton | 0.09352
GO:0015629 | actin cytoskeleton | 0.09352
GO:0001533 | cornified envelope | 0.00000
GO:0005882 | intermediate filament | 0.00000
GO:0015630 | microtubule cytoskeleton | 0.00000
GO:0005856a | cytoskeleton (annotated genes) | 0.8129656

### Performance on training data

- Error rate: 0
- Performance: 0.23708
- Redundancy: 1.90527

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 1
AML | 1 | 1

## GO:0005856 | ## cytoskeleton (annotated genes) | Cellular Component

### Parent node

GO:0005856 | cytoskeleton

### This leaf node contains 165 genes

### Performance on training data

- Error rate: 0
- Performance: 0.17152
- Redundancy: 2.09117

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 1
AML | 1 | 1

## GO:0015629 | ## actin cytoskeleton | Cellular Component

### Parent node

GO:0005856 | cytoskeleton

### 12 child nodes

ID | Term | Weight
--- | --- | ---
GO:0005858 | axonemal dynein complex | 0.00000
GO:0030864 | cortical actin cytoskeleton | 1
GO:0005884 | actin filament | 0.00000
GO:0042641 | actomyosin | 0.00000
GO:0005885 | Arp2/3 protein complex | 0.00000
GO:0005868 | cytoplasmic dynein complex | 0.00000
GO:0005869 | dynactin complex | 0.00000
GO:0008290 | F-actin capping protein complex | 0.00000
GO:0016459 | myosin | 0.00000
GO:0001725 | stress fiber | 0.00000
GO:0005865 | striated muscle thin filament | 0.00000
GO:0015629 | actin cytoskeleton | 0.00000

### Performance on training data

- Error rate: 0.05263
- Performance: 0.53949
- Redundancy: 1.44155

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 0.85714
AML | 0.85714 | 1

## GO:0005938 | ## cell cortex | Cellular Component

### Parent node

GO:0005622 | intracellular

### 4 child nodes

ID | Term | Weight
--- | --- | ---
GO:0000133 | polarisome | 0.00000
GO:0005826 | contractile ring | 0.00000
GO:0030864 | cortical actin cytoskeleton | 1
GO:0005938 | cell cortex | 0.00000

### Performance on training data

- Error rate: 0.05263
- Performance: 0.53949
- Redundancy: 1.44155

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 0.85714
AML | 0.85714 | 1

## GO:0030864 | ## cortical actin cytoskeleton | Cellular Component

### 1 parent node replaced:

GO:0030863 | cortical cytoskeleton

### Parent nodes

GO:0015629 | actin cytoskeleton
GO:0005856 | cytoskeleton
GO:0005938 | cell cortex

### 2 child nodes

ID | Term | Weight
--- | --- | ---
GO:0008091 | spectrin | 1
GO:0030864 | cortical actin cytoskeleton | 0.00000

### Performance on training data

- Error rate: 0.05263
- Performance: 0.53949
- Redundancy: 1.44155

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 0.85714
AML | 0.85714 | 1

## GO:0008091 | ## spectrin (annotated genes) | Cellular Component

### Parent node

GO:0030864 | cortical actin cytoskeleton

### This leaf node contains 6 genes

### Performance on training data

- Error rate: 0.05263
- Performance: 0.53949
- Redundancy: 1.44155

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 0.85714
AML | 0.85714 | 1

## GO:0000267 | ## cell fraction | Cellular Component

### Parent node

GO:0005623 | cell

### 4 child nodes

ID | Term | Weight
--- | --- | ---
GO:0005626 | insoluble fraction | 0.00000
GO:0005624 | membrane fraction | 0.9932
GO:0005625 | soluble fraction | 0.0068
GO:0000267 | cell fraction | 0.00000

### Performance on training data

- Error rate: 0.02632
- Performance: 0.11876
- Redundancy: 3.1645

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 0.92857
AML | 0.92857 | 1

## GO:0005625 | ## soluble fraction (annotated genes) | Cellular Component

### Parent node

GO:0000267 | cell fraction

### This leaf node contains 184 genes

### Performance on training data

- Error rate: 0.13158
- Performance: 0.58402
- Redundancy: 1.4574

| Sensitivity | Specificity
--- | --- | ---
ALL | 0.91667 | 0.78571
AML | 0.78571 | 0.91667

## GO:0005624 | ## membrane fraction | Cellular Component

### Parent node

GO:0000267 | cell fraction

### 4 child nodes

ID | Term | Weight
--- | --- | ---
GO:0000299 | integral to membrane of membrane fraction | 0.00000
GO:0019717 | synaptosome | 0.00000
GO:0005792 | microsome | 0.00000
GO:0005624a | membrane fraction (annotated genes) | 1

### Performance on training data

- Error rate: 0.02632
- Performance: 0.10563
- Redundancy: 3.48639

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 0.92857
AML | 0.92857 | 1

## GO:0005624 | ## membrane fraction (annotated genes) | Cellular Component

### Parent node

GO:0005624 | membrane fraction

### This leaf node contains 319 genes

### Performance on training data

- Error rate: 0.02632
- Performance: 0.10563
- Redundancy: 3.48639

| Sensitivity | Specificity
--- | --- | ---
ALL | 1 | 0.92857
AML | 0.92857 | 1