maLoess                package:marray                R Documentation

_S_t_r_a_t_i_f_i_e_d _u_n_i_v_a_r_i_a_t_e _r_o_b_u_s_t _l_o_c_a_l _r_e_g_r_e_s_s_i_o_n

_D_e_s_c_r_i_p_t_i_o_n:

     This function performs robust local regression of a variable 'y'
     on predictor variable 'x', separately within values of a third
     variable 'z'. It is used by 'maNormLoess' for intensity dependent
     location normalization.

_U_s_a_g_e:

     maLoess(x, y, z, w=NULL, subset=TRUE, span=0.4, ...)

_A_r_g_u_m_e_n_t_s:

       x: A numeric vector of predictor variables.

       y: A numeric vector of responses.

       z: Variables used to stratify the data.

       w: An optional numeric vector of weights.

  subset: A "logical" or "numeric" vector indicating the subset of
          points used to compute the fits.

    span: The argument 'span' which controls the degree of smoothing in
          the 'loess' function.

     ...: Misc arguments.

_D_e_t_a_i_l_s:

     'y' is regressed on 'x', separately within values of 'z' using the
     'loess' function.

_V_a_l_u_e:

     A numeric vector of fitted values.

_A_u_t_h_o_r(_s):

     Sandrine Dudoit, <URL: http://www.stat.berkeley.edu/~sandrine>.

_R_e_f_e_r_e_n_c_e_s:

     S. Dudoit and Y. H. Yang. (2002). Bioconductor R packages for
     exploratory analysis and normalization of cDNA microarray data. In
     G. Parmigiani, E. S. Garrett, R. A. Irizarry and S. L. Zeger,
     editors, _The Analysis of Gene Expression Data: Methods and
     Software_, Springer, New York.


     Y. H. Yang, S. Dudoit, P. Luu, and T. P. Speed (2001).
     Normalization for cDNA microarray data. In M. L. Bittner, Y. Chen,
     A. N. Dorsel, and E. R. Dougherty (eds), _Microarrays: Optical
     Technologies and Informatics_, Vol. 4266 of _Proceedings of SPIE_.


     Y. H. Yang, S. Dudoit, P. Luu, D. M. Lin, V. Peng, J. Ngai, and T.
     P. Speed (2002). Normalization for cDNA microarray data: a robust
     composite method addressing single and multiple slide systematic
     variation. _Nucleic Acids Research_, Vol. 30, No. 4.

_S_e_e _A_l_s_o:

     'maNormMain', 'maNormLoess', 'loess'.

_E_x_a_m_p_l_e_s:

     # See examples for maNormMain.

