ALZH              package:GeneticsBase              R Documentation

_S_a_m_p_l_e _f_r_o_m _N_a_t_i_o_n_a_l _I_n_s_t_i_t_u_t_e _o_f _M_e_n_t_a_l _H_e_a_l_t_h (_N_I_M_H) _G_e_n_e_t_i_c_s
_I_n_i_t_i_a_t_i_v_e _A_l_z_h_e_i_m_e_r'_s _D_i_s_e_a_s_e

_D_e_s_c_r_i_p_t_i_o_n:

     Sample from National Institute of Mental Health (NIMH) Genetics
     Initiative Alzheimer's Disease

_U_s_a_g_e:

     data(ALZH)

_F_o_r_m_a_t:

     Object of class 'geneSet'

_D_e_t_a_i_l_s:

     "This data set is a subsample from the National Institute of
     Mental Health (NIMH) Genetics Initiative Alzheimer's Disease (AD)
     Sample. The ascertainment and assessment of AD families collected
     have been discussed in Blacker et al. (1997). None of the families
     in this data set have parental genotype information; practically
     all of them have both affected and unaffected offspring. In total
     there are 901 individuals contained in 301 nuclear families.

     "Acknowledgements: We thank Genetics and Aging Research Unit,
     Rudolph E. Tanzi, PhD, Director, for providing the data.

     "Genotypes

     "The pedigree file, Alzh.ped, contains genotype information for
     two candidate genes, apoe and a2m.  The apoe gene is
     multi-allelic, while the a2m gene is bi-allelic.  The dataset also
     contains the affection status (2=affected, 1=unaffected,
     0=missing).

     "Phenotypes

     "We only will be using the Alzheimer dataset to examine affection
     status, which is contained in the pedigree file, thus a phenotype
     file for these data is not necessary."

     (quoted from Lange and Kraft 2005)

_S_o_u_r_c_e:

     Lange, C. and Kraft, P. (2005). "Short Course: Genetics
     Associateion Analysis."

_R_e_f_e_r_e_n_c_e_s:

     Lange, C. and Kraft, P. (2005). "Short Course: Genetics
     Associateion Analysis."

_E_x_a_m_p_l_e_s:

     library(GeneticsBase)
     data(ALZH)
     head(ALZH)

