Realdata {FEM} | R Documentation

## A dataset object derived from real DNA methylation and gene expression data from normal endometrial and endometrial cancer tissue

### Description

Realdata is a list containing data derived from mRNA Expression and DNA methylation from an endometrial cancer study. See Jones et al PLoS Med.2013 for details about the data.

### Usage

    data(Realdata)

### Value

`statM` | a matrix of statistics and p-values of differential DNA Methylation between endometrial cancer and normal tissue (cancer compared to normal) with rownames annotated with entrez gene IDs.
`statR` | a matrix of statistics and p-values of differential RNA Expression between endometrial cancer and normal tissue (cancer compared to normal) with rownames annotated with entrez gene IDs.
`adjacency` | adjacency matrix of PPI network, with number of rows equal to the number of rows of Realdata$statM, ordered in same way and with same gene identifier. The resulting graph is connected.
`fembi.o` | this entry represents the output of the function DoFEMbi() (see example below). This is included so as to avoid having to rerun the (lengthy) example from scratch.

### References

Jones A, Teschendorff AE, Li Q, Hayward JD, Kannan A, et al. (2013) Role of dna methylation and epigenetic silencing of hand2 in endometrial cancer development. PLoS Med 10:e1001551.

### Examples

    #data(Realdata);
    #intFEM.o <- list(statM=Realdata$statM,statR=Realdata$statR,adj=Realdata$adjacency);

[Package FEM version 3.12.0 Index]