centBloodSub.m {EpiDISH} | R Documentation

## Whole blood reference of 188 tsDHS-DMCs and 7 blood cell subtypes

### Description

This reference is a subset of `centDHSbloodDMC.m`, and contains 188 DMCs which exhibit similar median DNAm values across epithelial cells, fibroblasts and ICs to ensure that the estimation of IC subtype fractions is not confounded by the epithelial and fibroblast cells in the sample. It should be used in the `hepidish` function to estimate fractions of immunce cell subtypes.

### Usage

    data(centBloodSub.m)

### Format

A matrix with 188 rows and 7 columns

### Details

- B-cells

- CD4+ T-cells

- CD8+ T-cells

- NK-cells

- Monocytes

- Neutrophils

- Eosinophils

### References

Zheng SC, Webster AP, Dong D, Feber A, Graham DG, Sullivan R, Jevons S, Lovat LB, Beck S, Widschwendter M, Teschendorff AE A novel cell-type deconvolution algorithm reveals substantial contamination by immune cells in saliva, buccal and cervix. Epigenomics (2018) 10: 925-940. doi: 10.2217/epi-2018-0037.

Teschendorff AE, Breeze CE, Zheng SC, Beck S. A comparison of reference-based algorithms for correcting cell-type heterogeneity in Epigenome-Wide Association Studies. BMC Bioinformatics (2017) 18: 105. doi: 10.1186/s12859-017-1511-5.

Reinius LE, Acevedo N, Joerink M, Pershagen G, Dahlen S-E, Greco D, Soderhall C, Scheynius A, Kere J. Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility. PLoS ONE (2012) 7: e41361. doi: 10.1371/journal.pone.0041361.

[Package EpiDISH version 2.0.2 Index]