Substitution Type	Trinucleotide	Somatic Mutation Type	Signature 1	Signature 2	Signature 3	Signature 4	Signature 5	Signature 6	Signature 7	Signature 8	Signature 9	Signature 10	Signature 11	Signature 12	Signature 13	Signature 14	Signature 15	Signature 16	Signature 17	Signature 18	Signature 19	Signature 20	Signature 21	Signature 22	Signature 23	Signature 24	Signature 25	Signature 26	Signature 27	Signature 28	Signature 29	Signature 30
C>A	ACA	A[C>A]A	0.011098326	0.000682708	0.022172307	0.0365	0.014941548	0.0017	0.0004	0.036718004	0.012	0.0007	0.0002	0.0077	0.000334757	0.0001	0.0013	0.0161	0.001832019	0.050536419	0.0107	0.001179962	0.0001	0.00150407	0.000453361	0.028645993	0.009896768	0.002039773	0.005205627	0.001397439	0.069981987	0
C>A	ACC	A[C>A]C	0.009149341	0.000619107	0.017871675	0.0309	0.008960918	0.0028	0.0005	0.033245722	0.0067	0.001	0.001	0.0047	0.000648736	0.0042	0.004	0.0097	0.000342236	0.010939825	0.0074	0.002211505	0.0007	0.002451011	0.0003668	0.020214638	0.006998929	0.001487162	0.004738227	0.000917188	0.055152357	0
C>A	ACG	A[C>A]G	0.00149007	9.9279E-05	0.00213834	0.0183	0.002207846	0.0005	0	0.002525311	0.0005	0.0003	0	0.0017	3.81446E-05	0.0005	0	0.0022	1.57623E-06	0.002288073	0.0005	1.61691E-07	0	0	0	0.020478996	0.001448443	0.000283946	0.000782698	0	0.017846984	0.0019673
C>A	ACT	A[C>A]T	0.006233885	0.000323891	0.016265146	0.0243	0.009206905	0.0019	0.0004	0.03359855	0.0068	0.0092	0.0002	0.0046	0.000846658	0.0296	0.0057	0.0088	0.003179665	0.019424091	0.0074	0.00300801	0.0006	0.000922453	0	0.024600145	0.004966565	0.000597866	0.002718242	0.00051341	0.026804716	0
C>G	ACA	A[C>G]A	0.001801068	0.000263481	0.024002615	0.0097	0.011671022	0.0013	0	0.008356845	0.0048	0.0005	0.0007	0.0031	0.003775165	0.0001	0.0011	0.0048	0.001661704	0.001516888	0.0058	0.000697041	0.0005	0.000527644	0	0.011993039	0.008032568	0.001272881	0.001324163	0.000255195	0.009301971	0
C>G	ACC	A[C>G]C	0.002580909	0.000269866	0.012160304	0.0054	0.007292089	0.0012	0	0.00430638	0.0023	0.0003	0.0003	0.0015	0.000920825	0	0.0001	0.0024	0.001626898	0.002498785	0.0019	0.00205931	0.0008	0	0	0.00842512	0.00163597	0.001528195	0.001771084	0.000268899	0.003479049	0
C>G	ACG	A[C>G]G	0.000592548	0.000219234	0.005275419	0.0031	0.002303839	0	0	0.000584415	0	0	0	0	1.98905E-05	0	0.0006	0	2.58019E-05	0.002614509	0	1.2735E-05	0	0	0	0	0	0.000307246	0	0	0.000154434	0.00482
C>G	ACT	A[C>G]T	0.002963986	0.000610973	0.023277656	0.0054	0.011696246	0.0018	0.0001	0.008634907	0.0038	0.0002	0.0009	0.0025	0.003860632	0.0001	0.001	0.0073	0.001328508	0.003983011	0.0072	0.000848587	0.0018	0.000299455	0	0.003881383	0.00342845	0.002498252	0.00132272	0.000307698	0.00397679	0
C>T	ACA	A[C>T]A	0.029514533	0.007441557	0.017872171	0.012	0.021839188	0.0312	0	0.018066687	0.0093	0	0.0225	0.0121	0.001480181	0.0293	0.0117	0.0135	0.009350488	0.003825624	0.0221	0.032858047	0.0051	0.00311339	0.019767154	0.006315518	0.020987618	0.005907232	0.013723286	0.005433792	0.005197221	0.065119
C>T	ACC	A[C>T]C	0.014322747	0.002726312	0.008896034	0.0075	0.012756106	0.0163	0.0197	0.005650015	0.0056	0.0032	0.1099	0.0054	4.05087E-05	0.0321	0.0169	0.0076	0.004224289	0.002465214	0.0203	0.022196047	0.0062	0.00152486	0.08188058	0.003844327	0.013141284	0.010626458	0.005424306	0.001815415	0.00897647	0.054397
C>T	ACG	A[C>T]G	0.171646931	0.003322083	0.003572708	0.0028	0.016760177	0.0908	0.0001	0.019265105	0.0125	0.0126	0.0072	0.0019	0.000316595	0.0496	0.0309	0.0035	0.009229213	0.008463957	0.0368	0.034572015	0.0256	0.003625641	0.009248715	0.003110664	0.019659894	0.019930323	0.006706429	0.005432039	0.031638996	0.0204604
C>T	ACT	A[C>T]T	0.012623763	0.003326528	0.014797612	0.0059	0.016477955	0.0149	0.0043	0.020805967	0.0076	0.0047	0.0639	0.0067	0	0.0277	0.0066	0.0101	0.005735961	0.00560574	0.0266	0.01881956	0.003	0	0.033209652	0.003420419	0.005728519	0.011334531	0.004475614	0.001629213	0.004769667	0.0219359
T>A	ATA	A[T>A]A	0.00402152	1.32377E-07	0.008428564	0.0048	0.008902904	0.0006	0.001	0.013365083	0.0121	0	0.0002	0.0058	0.001243618	0	0.0021	0.0081	0.000613002	0.003037211	0.0011	0.000574401	0.0083	0.04961923	0	0.001166747	0.020430527	0.00445934	0.143076389	0.000964031	0	0.0075743
T>A	ATC	A[T>A]C	0.002371144	0.00011307	0.007373097	0.0039	0.007399202	0.0033	0.0008	0.012431202	0.0042	0.0002	0.0001	0.0065	0.001060002	0.0008	0.009	0.0073	0.001878587	0.000811167	0.0053	0.001971462	0.0292	0.01166674	0	1.51731E-05	0.008892561	0.012822243	0.001464085	0.003365668	0.003049596	0.003738
T>A	ATG	A[T>A]G	0.00281091	0.000532929	0.0073573	0.01	0.011508051	0	0.0009	0.014036657	0.0068	0	0.0007	0.0046	0.000102554	0	0.0009	0.008	0.00108735	0.004503207	0.0045	0.000190587	0.0027	0.067915454	0.000237419	0.006332456	0.006241948	0.001172344	0.001226281	0.001785754	0.003909982	0.0065906
T>A	ATT	A[T>A]T	0.008360909	0.000149111	0.008753939	0.003	0.011193623	0.0053	0.0035	0.024109917	0.0185	0.0012	0.0003	0.006	0.000971812	0.0009	0.0079	0.0084	0.002045494	0.002736523	0.0033	0.007421104	0.0043	0.014599918	0	4.96722E-06	0.014850878	0.003993138	0.002535198	0.005653089	0.005105527	0.0093447
T>C	ATA	A[T>C]A	0.013915773	0.00130351	0.013035709	0.0084	0.035366735	0.0075	0.0005	0.01620651	0.0252	0.0031	0.0006	0.0466	0.000549454	0.0026	0.0115	0.0717	0.002697314	0.002933054	0.0145	0.016395063	0.0265	0.016839931	0.001068449	0.004726009	0.020663283	0.055028652	0.005047301	0.004092747	0.010119181	0
T>C	ATC	A[T>C]C	0.006274961	0.000425577	0.00918629	0.002	0.013771102	0.0056	0.0001	0.007787803	0.0105	0.0052	0.0015	0.0317	0.000145507	0.0046	0.0073	0.0171	0.00807815	0.001513285	0.0048	0.019251794	0.0165	0.001108262	0.000221573	0.000627949	0.009502478	0.027594604	0.001845691	0.007880729	0.006349683	0.0087547
T>C	ATG	A[T>C]G	0.010137636	0.000575473	0.01171692	0.0081	0.028449052	0.0217	0.0007	0.009852584	0.0176	0.0026	0.0008	0.0487	0.000279178	0.0035	0.0073	0.0348	0.004432871	0.003329669	0.0135	0.054784918	0.0224	0.004913616	0.000498802	0.002723759	0.019911492	0.051791044	0.005688814	0.005520834	0.01465961	0.0090498
T>C	ATT	A[T>C]T	0.009256316	0.001488164	0.016978871	0.0036	0.027302974	0.0023	0.0011	0.021829464	0.0247	0.004	0.0003	0.025	0.000267461	0.0025	0.0063	0.0497	0.00314037	0.005491318	0.016	0.00734127	0.0189	0.002630524	0.000313241	0.007122368	0.01448839	0.039072244	0.002592755	0.003232484	0.007892413	0
T>G	ATA	A[T>G]A	0.001587636	3.37184E-05	0.002351368	0	0.003462152	0	0	0.004219719	0.0335	0	0	0.0012	0.0003862	0	0	0.0052	5.31392E-05	0.000386138	0.0014	1.76529E-06	0	0.001651999	0	0	0.00528168	8.06534E-05	0.001136337	0.006364676	0	0.0053118
T>G	ATC	A[T>G]C	0.001784091	2.48448E-05	0.001464231	0.0002	0.002246593	0.0017	0	0.000793671	0.0051	0.004	0	0.001	0.000112383	0.002	0.0006	0.0042	0.006468661	0.001254982	0	0.000381388	0.0031	0	0	0.001463951	0	0.000163171	0.000958976	0.016610906	0	0.0024592
T>G	ATG	A[T>G]G	0.001385831	0.000273454	0.009053778	0.0015	0.005490217	0.0007	0.0009	0.0068658	0.0052	0.0015	0.0001	0.0018	3.60007E-05	0.0007	0.0012	0.0061	0.003481549	0.002369216	0.001	0.000658758	0.0016	0.001086873	0	0.000847613	0.007136422	0.00125508	6.76606E-05	0.006592842	0.002925171	0.0062955
T>G	ATT	A[T>G]T	0.003158539	0.000217695	0.007030976	0.0002	0.003821227	0.0029	0	0.002939922	0.0193	0.0137	0	0.003	0.000192494	0.0056	0.0029	0.0076	0.030926375	0.000338603	0.0017	0.000532125	0.0018	0	0	0.001075455	0	0.001850383	0.000256028	0.086392897	0	0.0095416
C>A	CCA	C[C>A]A	0.00659587	0.000677445	0.018781726	0.0461	0.009674904	0.0101	0.0012	0.031723757	0.0098	0.0031	0.0007	0.0135	0.00171009	0.0056	0.0106	0.0159	0.00103243	0.088768109	0.0112	0.017377111	0.002	0.004549693	0.000164739	0.063559284	0.014832948	0.00370585	0.005065073	0.001168516	0.051410212	0
C>A	CCC	C[C>A]C	0.007342368	0.000213681	0.015760458	0.0614	0.004952301	0.0241	0.0006	0.025505407	0.0057	0.0009	0.0017	0.0112	0.001159257	0.0102	0.0084	0.01	0.00042188	0.020641391	0.0159	0.036502463	0.0014	0.003764474	0.000736875	0.033757005	0.007822175	0.003980723	0.002234153	0.000334292	0.025825651	0
C>A	CCG	C[C>A]G	0.00089284	6.77046E-06	0.00196339	0.0088	0.002800627	0.0091	0	0.001159624	0	0.0007	0.001	0.0028	0.000244167	0.0009	0.0015	0.0022	0.000297463	0.017178402	0.0018	0.012482588	0.0027	0.000900163	0.000163954	0.022428986	0.001276977	0.000811742	0.000266312	5.3652E-05	0.014496183	0.0022624
C>A	CCT	C[C>A]T	0.007186582	0.000416333	0.014722861	0.0432	0.011013466	0.0571	0.0013	0.028791173	0.0091	0.016	0.0014	0.0071	0.001256768	0.1257	0.0228	0.0084	3.14794E-05	0.037676959	0.0096	0.103401226	0.0056	0.004439846	0.000722732	0.020086515	0.012563655	0.019038431	0.00310057	0.000186672	0.040355074	0
C>G	CCA	C[C>G]A	0.001284983	2.77721E-05	0.016832572	0.0105	0.007537523	0	0.0001	0.006619077	0.0018	0	0	0.0019	0.005333651	0	0.0009	0.004	0.001924979	0.000458464	0.0002	1.33163E-05	0.0001	0.000582018	0.000199049	0.013476822	0.00720079	0.001279106	0.004730649	0.000103366	0.002618863	0
C>G	CCC	C[C>G]C	0.000702135	0.000279644	0.013531442	0.0097	0.007633227	0	0.0004	0.006077703	0.002	0	0.0002	0.0019	0.000912303	0	0.0003	0.005	0.000709368	0.003654228	0.0028	0.000548145	0	0.0008253	0.000283776	0.016105688	0.004598473	0.001214977	0.001261645	0.000144311	0.001111512	0
C>G	CCG	C[C>G]G	0.00050629	1.91616E-05	0.004176458	0.0063	0.00261376	0	0.0006	0.000656033	0	0	0.0008	0	0.000285467	0	0.0004	0.0028	3.51787E-06	0.005405774	0.0002	0	0	0.000382115	0	0.000797472	0.000823709	0.000207833	0.000360857	0	0.001520047	0.0032461
C>G	CCT	C[C>G]T	0.001381543	0.000312782	0.02404639	0.0094	0.009417098	0.0002	0.0003	0.007805027	0.0039	0	0.0002	0.0019	0.006383098	0	0.0017	0.008	0.000953776	0.005519605	0.0008	0.000120731	0.0003	0.001760646	0.000195775	0.010388666	0.00019636	0.002297026	0.000268026	0.000291	0.000139751	0
C>T	CCA	C[C>T]A	0.020896447	0.015019507	0.014395059	0.021	0.022769209	0.0085	0.0754	0.00486581	0.0098	0.0012	0.031	0.0187	0.003647278	0.006	0.0051	0.021	0.021265206	0.009767511	0.0438	0.011145185	0.0034	0.00773135	0.060572628	0.006035447	0.014333995	0.006594445	0.017438485	0.004391533	0.009126472	0.0694472
C>T	CCC	C[C>T]C	0.018501705	0.003516918	0.008544781	0.0144	0.017509476	0.0099	0.1007	0.00398015	0.0069	0.0024	0.1518	0.0094	0.001004229	0.0167	0.0088	0.0098	0.003847235	0.005654828	0.0753	0.018152747	0.0091	0.007110851	0.186375634	0	0.005936644	0.006510632	0.00714487	0.002647661	0.007067603	0.0638403
C>T	CCG	C[C>T]G	0.095577217	0.004979276	0.003518466	0.0076	0.012862238	0.0901	0.0208	0.008338639	0.0076	0.0109	0.0135	0.0046	0.000129202	0.0293	0.0155	0.0016	0.013176112	0.016183223	0.0238	0.044384942	0.0318	0.005502031	0.015149083	0.002924419	0.011559392	0.011904935	0.007503562	0.002284564	0.01987518	0.0173126
C>T	CCT	C[C>T]T	0.017113308	0.008956553	0.016075546	0.0201	0.020429513	0.0087	0.0788	0.018843627	0.0097	0.0043	0.0816	0.0205	0.00061177	0.0186	0.0096	0.0211	0.009648025	0.005153319	0.1159	0.013847136	0.004	0.004169777	0.156015397	0.003971202	0.013632597	0.006238556	0.007148028	0.002423984	0.001634059	0.0342318
T>A	CTA	C[T>A]A	0.001182587	0.000154599	0.00757132	0.0075	0.005043164	0.0001	0	0.012024218	0.0055	0	0.0004	0.0017	0.000285159	0	0.0016	0.0054	3.00792E-05	0.000412346	0.0043	4.50424E-05	0	0.086898546	0.000594528	0.002766635	0.026296323	0.003561423	0.330601017	0.00256658	0.001765448	0.0053118
T>A	CTC	C[T>A]C	0.001903167	0.000464019	0.012725464	0.0111	0.006208844	0.0026	0.0014	0.017881092	0.0049	0.0001	0.0011	0.0086	0.000222287	0.0034	0.0043	0.0128	0.010223748	0.002491411	0.0053	0.004389056	0.0037	0.053706847	0	0.002694462	0.015799883	0.003901611	0.002813599	0.019610897	0.000383359	0.0067873
T>A	CTG	C[T>A]G	0.001487961	0.00023041	0.011508562	0.0342	0.010507569	0.0008	0.0007	0.016356775	0.0051	0.0003	0.0006	0.0031	0.000286952	0.0002	0.0027	0.013	0.004467036	0.005523046	0.0021	0.001127836	0.0025	0.213220867	0.00017312	0.006911165	0.062860606	0.002390304	0.004396857	0.0088336	0.003556845	0.0082628
T>A	CTT	C[T>A]T	0.002179344	0.000574886	0.016456178	0.0115	0.009784641	0.0011	0.0018	0.026247802	0.0069	0.0009	0.0004	0.0054	8.00446E-07	0.002	0.0007	0.0096	0.031244883	0.003313713	0.0022	0.002385541	0.001	0.061827507	0.000457813	0.0029152	0.036622351	0.001635923	0.005430892	0.01094261	0.002232755	0
T>C	CTA	C[T>C]A	0.004176675	0.000546619	0.007895013	0.0052	0.01423863	0.0062	0.001	0.005173842	0.0154	0.0005	0.0001	0.0312	4.27515E-05	0.0006	0.0032	0.0146	0.007427	0.000192169	0.0066	0.014867697	0.0219	0.004027346	0	0.001848877	0.009028015	0.037889378	0.004899079	0.020738003	0	0
T>C	CTC	C[T>C]C	0.005252593	0.000392333	0.01443117	0.0026	0.0124895	0.004	0.0008	0.010936894	0.0118	0.0019	0.0004	0.0385	4.33075E-05	0.0053	0.005	0.0194	0.039657001	0.003050193	0.007	0.018356161	0.01	0.001352444	0	0.00445369	0.010771632	0.021740735	0.005724448	0.043283797	0.002774954	0
T>C	CTG	C[T>C]G	0.007013225	0.000362025	0.008422972	0.01	0.018741631	0.027	0.001	0.005657774	0.0154	0.0015	0.0001	0.0415	5.42725E-05	0.0016	0.0128	0.019	0.028609696	0.002596464	0.004	0.074150563	0.0211	0.002749666	0.000320705	0	0.013350661	0.047240103	0.005661479	0.037088262	0.006902415	0
T>C	CTT	C[T>C]T	0.006713813	0.0005609	0.01193243	0.0054	0.019054083	0.0033	0.0045	0.011120389	0.0275	0.002	0.0009	0.0324	7.63944E-07	0.0027	0.0035	0.0263	0.101869658	0.001310029	0.0053	0.011001118	0.0204	0.002363354	0	0.001597389	0.00896103	0.020740621	0.003900589	0.005052716	0.003041425	0
T>G	CTA	C[T>G]A	0.000302691	0.000113785	0.001974181	0	0.002041649	0.0001	0	0.002424051	0.0216	0.0022	0	0.0013	1.50942E-05	0	0	0.0002	9.14698E-05	6.10025E-05	0	2.32641E-05	0	0.001120357	0	0	0	9.53963E-05	0	0.009589842	0.001116855	0.0046233
T>G	CTC	C[T>G]C	0.002098502	2.20951E-05	0.005824296	0.0013	0.003478502	0.004	0.0008	0.002096211	0.0064	0.0018	0.0001	0.0049	0.000147625	0.002	0.0019	0.0082	0.019814294	0.002015697	0.0011	0.008476495	0.0005	0.001064584	0.000190144	0.002185437	0.002886454	0.003919455	0.000381245	0.033913224	0	0.0060004
T>G	CTG	C[T>G]G	0.001599549	0.000228246	0.010464655	0.0046	0.007147456	0.005	0.0009	0.006604046	0.0126	0.0037	0.0011	0.0045	4.59873E-05	0.0005	0.0007	0.0067	0.013449838	0.005311967	0.0013	0.015383776	0.0004	0.004188568	0	0.00011391	0.011769492	0.005497357	0.000403257	0.018516482	0.002169693	0.0073775
T>G	CTT	C[T>G]T	0.002758538	6.71113E-05	0.008724387	0.0012	0.011486812	0.0086	0.0013	0.004866714	0.0509	0.0182	0.0009	0.0063	0.000463715	0.0063	0.0045	0.0186	0.261456614	0.002341629	0.0019	0.002185395	0.0032	0.00162941	0.000210835	0.002533718	0.008550807	0.006788719	0.001439096	0.118967103	0.001143663	0.0091481
C>A	GCA	G[C>A]A	0.008232604	0.000352013	0.00969654	0.0376	0.011892169	0.0024	0.0003	0.023682329	0.0118	0.0014	0.0004	0.0062	0.00013211	0.0018	0.0024	0.0096	0.006535405	0.128724158	0.0032	0.001116124	0.0001	0.00129837	0.000349907	0.054676449	0.013465295	0.001375312	0.010755872	0.002136629	0.07804661	0.008853
C>A	GCC	G[C>A]C	0.005758021	0.000133817	0.010843341	0.0399	0.009247857	0.0058	0.0001	0.015821896	0.0092	0.0022	0.001	0.0056	0.000754244	0.0114	0.0099	0.0094	0.001293804	0.016092879	0.0031	0.003271429	0.0038	0.001809622	0.000568338	0.109945989	0.006468298	0.001961639	0.012442335	0.000429208	0.073460915	0.0093449
C>A	GCG	G[C>A]G	0.000616335	0.000178442	0.000929141	0.0227	0.002809188	0.0021	0	0.000850914	0	0.0002	0	0.0015	9.68208E-05	0.0011	0.0013	0.0036	0.001283663	0.009271417	0	0.003751613	0.0003	0.000333838	0.000149418	0.046524869	0.000658103	1.32297E-05	0.001629628	0	0.017383297	0.0008853
C>A	GCT	G[C>A]T	0.00445908	0.000122832	0.012215383	0.0258	0.010301267	0.0087	0.0001	0.021061236	0.0085	0.0088	0.0006	0.0027	0.000551104	0.0736	0.0309	0.0063	0.003103767	0.07201707	0.0072	0.012937194	0.0023	0.000519148	0	0.050428709	0.01047308	0.001934996	0.007412355	0.001318507	0.059602472	0.0081645
C>G	GCA	G[C>G]A	0.000602123	4.48385E-05	0.011916845	0.007	0.005559423	0	0	0.003724568	0.0011	0	0	0.0012	0.00134942	0.0002	0.0022	0.0031	0.001296324	0.00092388	0.002	0.001339769	0.0004	0	0	0.004945061	0.004169656	0.001320607	0.001418166	8.15914E-05	0.00026576	0.0073775
C>G	GCC	G[C>G]C	0.002393352	1.45201E-05	0.009823653	0.0091	0.005388801	0.003	0.0004	0.003046597	0.0029	0.0002	0.0002	0.0011	0.000788808	0.0001	0.0005	0.0032	0.000260761	0.000648648	0	0.001811151	0.0042	0	0.000137501	0.009369876	0.002392805	0.001845501	0.001346717	0.000105219	0.000945013	0.0065906
C>G	GCG	G[C>G]G	2.48534E-07	4.06659E-05	0.001671054	0.0062	0.00110059	0	0	0.000321213	0	0	0	0	8.17912E-05	0	0.0006	0	4.37755E-06	0.00054284	0	6.37538E-07	0	0.000214696	0	0.005625727	0.000418194	0.000205061	0	0	0	0.0015739
C>G	GCT	G[C>G]T	0.000890081	0.000268429	0.017914334	0.006	0.006041248	0.0017	0	0.005775664	0.0044	0.0004	0	0.0009	0.002680123	0.0003	0.0018	0.0029	0.001820393	0.001376725	0	0.001238264	0.0004	0.000538439	0	0.00305577	0.001994012	0.001225533	0.004560686	0.000159679	0.004796745	0
C>T	GCA	G[C>T]A	0.024943814	0.006390808	0.016127273	0.0087	0.020038259	0.0653	0	0.002261263	0.0062	0	0.0261	0.0124	0.002934138	0.0557	0.0476	0.0125	0.002068755	0.002703069	0.0374	0.056793948	0.0163	0.001915371	0.053282059	0.023679051	0.010038112	0.009606515	0.014215314	0.003384241	0.011638793	0.0485934
C>T	GCC	G[C>T]C	0.027161494	0.001995817	0.008208632	0.008	0.018022312	0.0773	0.021	0.001616649	0.0069	0.0134	0.0975	0.0092	0.002515171	0.0618	0.1345	0.0092	0.000325483	0.004199308	0.0614	0.054429857	0.0392	0.003229134	0.162918344	0.015919202	0.006953875	0.019507427	0.020143646	0.001687414	0.003781752	0.0494787
C>T	GCG	G[C>T]G	0.103570762	0.000303021	0.001212923	0.0023	0.013193818	0.1339	0.0002	0.011606712	0.0088	0.027	0.009	0.0023	0.003205265	0.0978	0.1829	0.0009	0.007511101	0.011897361	0.0278	0.004592689	0.0019	0.003300599	0.013046495	0.012648078	0.010468363	0.022502717	0.009368468	0.002189309	0.019684388	0.0157387
C>T	GCT	G[C>T]T	0.017689854	0.003265818	0.010611649	0.0082	0.019502915	0.0524	0.0161	0.006284929	0.0101	0.0152	0.0522	0.0115	0.001687731	0.0555	0.08	0.0116	0.000925697	0.001913381	0.0917	0.049580864	0.0166	0.00111406	0.1075904	0.018129778	0.009823821	0.017307472	0.007589626	0.001043994	0.005761337	0.0188865
T>A	GTA	G[T>A]A	0.000689289	0.000114994	0.004434783	0.0069	0.006740388	0	0	0.008139179	0.003	0	0.0003	0.0015	0.00013796	0	0	0.003	8.54569E-06	0.001875434	0.0026	0.00016313	0	0.053709146	0	0.002225127	0.036217801	0.002242887	0.109851872	0.000551461	0.002930098	0.003738
T>A	GTC	G[T>A]C	0.00055241	0.000293862	0.005615432	0.0052	0.004021596	0.0028	0	0.00791008	0.0029	0.0001	0.0003	0.0039	0.000252867	0.0025	0.0038	0.004	0.002573467	0.00151031	0	0.00379918	0.0142	0.009489397	0.000183204	0.004853149	0.00584711	0.005207287	2.34557E-05	0.003163988	0	0.0033445
T>A	GTG	G[T>A]G	0.001200229	8.87213E-05	0.008070136	0.0133	0.006814352	0.0006	0.0006	0.009057263	0.0028	0	0.0004	0.0019	0.000153517	0	0.0026	0.0051	0.003538823	0.001505369	0.0016	0.000828334	0.0031	0.050293902	0	0.000195759	0.038241179	0.001358122	0.001565937	0.002152847	0.000533632	0.0050167
T>A	GTT	G[T>A]T	0.002107137	0.000215755	0.008679122	0.0045	0.005101033	0.0021	0.001	0.017812239	0.0036	0.0004	0.0001	0.0031	0.000122746	0.0009	0.0043	0.0033	0.00387901	0.003611025	0.0052	0.001900747	0.0041	0.010601457	0	0	0.020167954	0.002513113	0	0.002007733	0	0.0063939
T>C	GTA	G[T>C]A	0.011247835	4.67385E-06	0.006850056	0.0061	0.016294983	0.0122	0.0002	0.005720779	0.0091	0.0064	0.001	0.0573	0.001054081	0.0078	0.0195	0.0161	1.14013E-05	0.000529126	0.0039	0.002469317	0.1426	0.004217454	0.000251169	0.00126975	0.017489824	0.098052825	0.00477738	0.003655048	0.007090804	0
T>C	GTC	G[T>C]C	0.006999724	0.000186066	0.006260749	0.0016	0.009574561	0.0059	0.0001	0.005181052	0.0097	0.0101	0.0016	0.0274	0.0005299	0.0127	0.0499	0.0099	0.009657713	0.002279131	0.003	0.001565633	0.0665	0	0.000538218	0.00671034	0.004045612	0.040226364	0.001964954	0.007071175	0.007111328	0.0065906
T>C	GTG	G[T>C]G	0.004977593	4.95044E-07	0.006098763	0.0042	0.014103929	0.0115	0.0003	0.005040707	0.0094	0.0054	0.0019	0.041	0.000630096	0.0082	0.0154	0.0148	0.004654129	0.005871057	0.006	0.027341755	0.0884	0.001474885	0	0.000277685	0.013402246	0.044620701	0.001229168	0.008232238	0.005643064	0.0078694
T>C	GTT	G[T>C]T	0.010667406	0.000578598	0.007509344	0.0024	0.015666875	0.0042	0.0081	0.00848822	0.0126	0.0124	0.0023	0.0405	0.000676188	0.0086	0.0094	0.0142	0.008149235	0.004771566	0.0099	0.001498265	0.1003	0.001561043	0.00099577	0.004238478	0.014159694	0.055528068	0.003747225	0.000407885	0.011237674	0.0084596
T>G	GTA	G[T>G]A	9.9045E-05	9.55524E-05	0.004144488	0	0.001627665	0	0	0.000974579	0.0072	0	0	0	1.84899E-05	0	0	0	3.91938E-05	0.001341532	0	3.57915E-06	0	0	0	0	0.005546227	3.73932E-05	0	0	0	0.0032461
T>G	GTC	G[T>G]C	0.000202366	4.70024E-05	0.004501985	0	0.000327735	0.0016	0	0.000524822	0.0006	0.002	0	0.0004	9.33735E-05	0.0019	0.0022	0.0032	0.009078462	9.20431E-07	0	0.002830575	0.0006	0	0	0.001073632	0	0.002460705	5.07906E-05	0	0	0.001869
T>G	GTG	G[T>G]G	0.001188353	0.000109926	0.016391453	0.0018	0.00594888	0.001	0.0017	0.006087753	0.005	0.0009	0.001	0.0011	1.05792E-05	0.0012	0.0037	0.0008	0.004782775	0.009695	0.0043	0.002733219	0.0004	0.001877589	0.000187132	0.002924697	0.008685244	0.000817202	0.004742919	0.004217808	0.003640594	0.0033445
T>G	GTT	G[T>G]T	0.000800723	8.64772E-05	0.007067237	0.0002	0.003307467	0.0035	0.0009	0.005427434	0.0185	0.003	0	0.0032	5.37412E-05	0.0038	0.019	0.0044	0.063497757	0.002890554	0.0025	0.003558559	0.0008	0	0	0.000825098	0.002768572	0.007833561	0.002298476	0.031648997	0.006181024	0.0056069
C>A	TCA	T[C>A]A	0.012250064	0.015127428	0.011653225	0.033	0.014774016	0.0017	0.001	0.027032383	0.0222	0.0374	0.0009	0.0066	0.048166048	0.0005	0.0057	0.0122	0.001824558	0.067080644	0.0051	0.0006883	0.0001	0.004051635	0.00207129	0.031451263	0.006938147	0.002680062	0.007079285	0.000775903	0.026894407	0
C>A	TCC	T[C>A]C	0.011162229	0.006532492	0.016606775	0.0538	0.012043465	0.0029	0.002	0.018089773	0.0043	0.0103	0.0025	0.0099	0.017329557	0.0166	0.0062	0.0145	0.001286518	0.04186901	0.0063	0.004058229	0.0005	0.002739771	0.00069641	0.062538294	0.010246607	0.002031644	0.006268801	0.000829292	0.031608137	0
C>A	TCG	T[C>A]G	0.002275496	0.001656455	0.001357239	0.0104	0.003902362	0.0011	0.0002	0.001694875	0	0.0031	0.0001	0.0019	0.002293157	0	0.0025	0.004	0.002172942	0.015162379	0.0018	0.001001102	0	0.000513151	9.93936E-05	0.012802591	0	0.000265072	0.001446403	0	0.012500468	0.0016722
C>A	TCT	T[C>A]T	0.015259102	0.012394611	0.016328076	0.037	0.018243396	0.0058	0.0013	0.038141331	0.0322	0.3083	0.0004	0.0049	0.018634582	0.0516	0.0145	0.0157	0.005012316	0.117877847	0.0087	0.012229105	0.0004	0.003605651	0.00020743	0.03029768	0.024625787	0.003017187	0.009806278	0.001998074	0.041207176	0
C>G	TCA	T[C>G]A	0.001874853	0.037241853	0.016041405	0.0032	0.002681057	0	0.0002	0.004117879	0.0033	0	0.0001	0.0024	0.280234947	0	0.0009	0.005	0.000392685	0.001802969	0.0005	2.42985E-05	0.0002	0.000225491	0.000230609	0.010220857	0.009798725	0.004201897	0.002870434	0.00052137	0.000820445	0
C>G	TCC	T[C>G]C	0.002067419	1.94134E-05	0.02014992	0.0105	0.007924048	0.0002	0.001	0.00379965	0.0025	0	0.0011	0.0027	0.063885287	0	0.0026	0.0064	0.000655602	0.007863007	0.0011	0.000151999	0.0003	0.000628695	0.000165787	0.007578365	0.003266507	0.002807762	0.003107968	0.000667326	0.000444119	0
C>G	TCG	T[C>G]G	0.000304897	0.001625465	0.002527911	0.0031	0.001319076	0	0.0003	2.5653E-05	0	0	0.0003	0	0.009528486	0	0	0	1.36415E-05	0.001513223	0	0	0	0.000395808	0	0.001592714	0.002057437	6.197E-09	1.28104E-05	0	0.000143297	0.0019673
C>G	TCT	T[C>G]T	0.003151574	0.0668799	0.032673641	0.005	0.006644596	0.0001	0.0007	0.006247554	0.0049	0.0001	0.0008	0.0015	0.330225482	0.0001	0.0015	0.0169	0.00285238	0.003567102	0.0105	0.00068306	0.0003	0.000257375	0.000438956	0.006100727	0.016400917	0.008019383	0.002130588	0.00124578	0.001369869	0
C>T	TCA	T[C>T]A	0.0144921	0.4199414	0.008880209	0.0035	0.01099756	0.0074	0.1202	0.007180669	0.005	0.0037	0.0302	0.0138	0.113842093	0.0092	0.0112	0.0172	0.016100785	0.014923392	0.0218	0.010710322	0.0064	0.002016722	0.014558614	0.026571894	0.011077521	0.011303289	0.018757776	0.007622258	0.012076583	0.0849892
C>T	TCC	T[C>T]C	0.017680775	0.081972496	0.013529573	0.007	0.020644965	0.0067	0.2887	0.004061033	0.0084	0.0211	0.1589	0.0095	0.015024839	0.0283	0.0156	0.0131	0.016779984	0.009962744	0.033	0.00817551	0.0086	0.001990834	0.043510447	0.012055691	0.006448788	0.010807527	0.007989184	0.005116619	0	0.090301
C>T	TCG	T[C>T]G	0.076002222	0.047720186	0.001705409	0.0011	0.00753449	0.0391	0.0992	0.005535122	0.0047	0.2141	0.008	0.001	0.006102098	0.0094	0.0104	0.0036	0.016272096	0.011549715	0.009	0.023163899	0.0126	0.001498473	0.002752641	0.00536336	0.014083416	0.010364329	0.004609131	0.001918028	0.015830197	0.0151485
C>T	TCT	T[C>T]T	0.013761704	0.228674918	0.010304417	0.0077	0.011787462	0.0047	0.0844	0.01220907	0.0096	0.0392	0.0954	0.009	0.028140661	0.0229	0.0076	0.0193	0.019827418	0.005398014	0.0267	0.009540087	0.0064	0.001182227	0.024328785	0.005532499	0.012418586	0.007249145	0.011880932	0.006193159	0.013462137	0.045544
T>A	TTA	T[T>A]A	0.005600155	8.07525E-05	0.007132681	0.0045	0.009205637	0.0002	0.001	0.015139996	0.0215	0	0.0003	0.0057	0.000403261	0	0.0008	0.0085	0.000698812	0.004663278	0.0039	0.000924548	0.0027	0.040810503	0	0	0.021830329	0.000628145	0.052813887	0.000203238	0.001191207	0.0076726
T>A	TTC	T[T>A]C	0.001999079	4.8029E-06	0.009102798	0.0046	0.006835344	0.0008	0.0015	0.012093555	0.0027	0.0008	0	0.0132	0.000771813	0.0016	0.0019	0.0087	0.002579359	0.002578156	0.0048	0.000708207	0.0045	0.025570396	0	0.007994129	0.003405687	0.005073754	4.70918E-05	0.010180965	0.001682664	0.0064922
T>A	TTG	T[T>A]G	0.001090066	6.6605E-05	0.006565863	0.0082	0.007144209	0	0.001	0.008362547	0.014	0	0	0.0037	0.000245194	0	0.0006	0.0063	2.11336E-05	0.002016738	0.0052	9.70031E-05	0	0.069845218	0.000231526	0.011202144	0.01019152	2.01384E-05	0	0.003250427	0.002438756	0.0036396
T>A	TTT	T[T>A]T	0.003981023	0.000276316	0.014712135	0.0045	0.01024085	0.0007	0.005	0.027653296	0.0139	0.0028	0.0008	0.0094	0.000160346	0.0012	0.0003	0.008	0.003883131	0.002818679	0.0085	0.002313489	0.0008	0.023579062	0	0.000270579	0.014527539	0.001235538	0.001929771	0.016492812	0	0
T>C	TTA	T[T>C]A	0.008073616	0.000101932	0.009115495	0.0028	0.017059641	0.0059	0.0023	0.004901072	0.0156	0.003	0.0002	0.05	0.000784056	0.0018	0.0068	0.0246	0.001708587	0.000302304	0.0052	0.00573423	0.0389	0.00480367	0	0.001682291	0.01451505	0.028789681	0.001721015	0.009929552	0.011498666	0
T>C	TTC	T[T>C]C	0.004857381	0.000470344	0.010953791	0.0016	0.014195709	0.0035	0.0018	0.006081011	0.0137	0.0097	0.0009	0.0342	0.000132975	0.0056	0.0099	0.0183	0.011074152	0.006260791	0.002	0.011234255	0.0313	0.000912158	0.000230609	0.002344528	0.007406083	0.036639492	0.003489213	0.029010563	0.003584215	0.0091481
T>C	TTG	T[T>C]G	0.008325454	0.000192354	0.006113033	0.0036	0.012596502	0.0106	0.0019	0.001712485	0.0098	0.0065	0.0007	0.032	3.74024E-05	0.0034	0.0039	0.0165	0.005932003	0.001541265	0.0057	0.023767611	0.0249	0.001781736	0.000239514	0.000481274	0.004892531	0.019143694	0.001152847	0.015683219	0.001694297	0.0060004
T>C	TTT	T[T>C]T	0.006257106	0.00058533	0.010774336	0.0022	0.017375139	0.0029	0.0024	0.010003442	0.0309	0.0099	0.0005	0.0371	0.000179703	0.0026	0.0047	0.0174	0.007208218	0.001357797	0.0038	0.005395186	0.0274	0	0	0.000358148	0.017014781	0.023071689	0.001527957	0.017291564	0.003799706	0
T>G	TTA	T[T>G]A	0.001397554	7.1737E-05	0.005427184	0	0.005202874	0.0009	0	0.001743221	0.0502	0.005	0	0.0019	0.000546582	0	0	0.0068	0.000133411	3.63184E-05	0.0032	2.69147E-07	0	0.001651699	0	0	0.00208148	8.53494E-06	0.001189022	0.009389659	0	0.0086563
T>G	TTC	T[T>G]C	0.001291737	1.42815E-05	0.00616025	0.0003	0.005131608	0.0019	0.001	0.002549838	0.0081	0.0092	0	0.0027	0.000235347	0.0015	0.0004	0.0069	0.009613345	0.003233838	0.0018	0.000377234	0.0018	0	0	0	0.000578979	0.00271851	0.000280295	0.030117077	0	0.0043282
T>G	TTG	T[T>G]G	0.002031077	0.000206615	0.011076526	0.003	0.006055254	0.0011	0.001	0.006030395	0.0088	0.0022	0.0003	0.0011	4.79022E-07	0.0002	0.0009	0.0049	0.004522462	0.000754602	0.0011	0.000515422	0.0003	0.002572752	0.000247502	0.001360505	0.009429196	0.001369161	0.002353056	0.012698751	0.000353696	0.0082628
T>G	TTT	T[T>G]T	0.004030128	2.35982E-05	0.013000984	0.0011	0.013369936	0.0072	0.0014	0.007223999	0.0545	0.0633	0.0003	0.0032	0.000670588	0.0025	0.0033	0.0163	0.058040408	0.002126442	0.0013	0.000615657	0.0003	0	0	6.95158E-05	0.007869672	0.002568077	0.000139561	0.233659783	0.006104834	0