# Integration of Disease Similarity Methods

####
Min Li (limin@mail.csu.edu.cn) Peng Ni (nipeng@csu.edu.cn)
School of Information Science and Engineering, Central South University, Changsha, 410083, China.

#### 2016-10-17

# Contents

# 1 Abstract

Discovering disease-disease simialrties can be useful for us to inferring the mechanisms of complex diseases. Disease similarity has become the important basis in disease-related molecular function research. There have been a number of methods proposed for measuring disease similarity in recent years. But there are lacks of tools or web servers for the computation of these methods. We present an R package dSimer which provides computation of nine methods for measuring disease-disease similarity, including a standard cosine similarity measure and eight function-based methods. The disease similarity matrix obtained from these nine methods can be visualized through heatmap and network. Biological data widely used in disease-disease associations study are also provided by dSimer.

# 2 Introduction

The quantification of similarity among diseases has drawn more and more attention in modern biology and medicine. Understanding similarity among diseases can not only help us gain deeper insights into complex diseases, but also lead to improvements in disease diagnosis, drug repurposing and new drug development. Due to the growing body of high-throughput biological data such as genomic and proteomic data, a number of methods have been proposed for the computation of similarity among diseases during the past decade.

Here we present dSimer for the calculation of nine disease similarity methods, including one standard cosine similarity method [1, 2] and eight function-based methods which compare disease-related gene set for calculating [3]. Besides, we also implemented methods for the visualization of disease similarity matrix.

To start with dSimer package, type following codes below:

    library(dSimer)
    help("dSimer")

# 3 The standard cosine similarity method

The cosine similarity method is a widely used standard measure in disease association analyses [1, 2]. First it constructs feature vectors for diseases from literature or by using other biological data. Then it calculate the cosine of the angle between normalized vector pairs as the similarity scores between diseases. We implemented function CosineDFV for this method:

    data(d2s_hsdn) #get disease-symptom associations for constructing feature vectors
    ds <- sample(unique(d2s_hsdn[,2]), 5) #get disease names sample
    simmat <- CosineDFV(ds, ds, d2s_hsdn)
    simmat

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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Lupus Nephritis
    ## Lupus Nephritis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1.0000000000
    ## Uterine Cervical Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                0.0007900049
    ## Tuberculosis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             0.0396889804
    ## Silo Fillers Disease\t1\t1.3147291510963324\nCough\tAnti-Glomerular Basement Membrane Disease\t3\t3.944187453288997\nCough\tHistiocytosis, Langerhans-Cell\t10\t13.147291510963324\nCough\tIdiopathic Pulmonary Fibrosis\t29\t38.12714538179364\nCough\tPneumoconiosis\t19\t24.979853870830315\nCough\tAsbestosis\t9\t11.83256235986699\nCough\tByssinosis\t4\t5.2589166043853295\nCough\tSilicosis\t8\t10.517833208770659\nCough\tSarcoidosis, Pulmonary\t20\t26.29458302192665\nCough\tWegener Granulomatosis\t9\t11.83256235986699\nCough\tLung Diseases, Obstructive\t93\t122.26981105195891\nCough\tPulmonary Disease, Chronic Obstructive\t90\t118.3256235986699\nCough\tLung Injury\t1\t1.3147291510963324\nCough\tMeconium Aspiration Syndrome\t1\t1.3147291510963324\nCough\tBronchopulmonary Dysplasia\t2\t2.6294583021926647\nCough\tPneumonia\t95\t124.89926935415157\nCough\tPleuropneumonia\t1\t1.3147291510963324\nCough\tPneumonia, Aspiration\t35\t46.01552028837163\nCough\tPneumonia, Lipid\t5\t6.573645755481662\nCough\tPulmonary Alveolar Proteinosis\t7\t9.203104057674327\nCough\tPulmonary Atelectasis\t20\t26.29458302192665\nCough\tMiddle Lobe Syndrome\t5\t6.573645755481662\nCough\tPulmonary Edema\t21\t27.60931217302298\nCough\tPulmonary Embolism\t22\t28.92404132411931\nCough\tPulmonary Emphysema\t31\t40.756603683986306\nCough\tLung, Hyperlucent\t1\t1.3147291510963324\nCough\tPulmonary Eosinophilia\t30\t39.44187453288997\nCough\tPulmonary Fibrosis\t27\t35.49768707960097\nCough\tPulmonary Veno-Occlusive Disease\t1\t1.3147291510963324\nCough\tRespiratory Distress Syndrome, Adult\t8\t10.517833208770659\nCough\tRespiratory Distress Syndrome, Newborn\t6\t7.888374906577994\nCough\tScimitar Syndrome\t2\t2.6294583021926647\nCough\tNose Diseases\t6\t7.888374906577994\nCough\tEpistaxis\t2\t2.6294583021926647\nCough\tNasal Obstruction\t4\t5.2589166043853295\nCough\tNasal Polyps\t1\t1.3147291510963324\nCough\tParanasal Sinus Diseases\t3\t3.944187453288997\nCough\tSinusitis\t46\t60.47754095043129\nCough\tMaxillary Sinusitis\t2\t2.6294583021926647\nCough\tRhinitis\t54\t70.99537415920194\nCough\tRhinitis, Allergic, Perennial\t18\t23.66512471973398\nCough\tRhinitis, Allergic, Seasonal\t24\t31.553499626311975\nCough\tRhinitis, Atrophic\t1\t1.3147291510963324\nCough\tRhinitis, Vasomotor\t1\t1.3147291510963324\nCough\tPleural Diseases\t11\t14.462020662059656\nCough\tChylothorax\t1\t1.3147291510963324\nCough\tHydrothorax\t2\t2.6294583021926647\nCough\tPleural Effusion\t21\t27.60931217302298\nCough\tPleurisy\t9\t11.83256235986699\nCough\tPneumothorax\t23\t30.238770475215645\nCough\tRespiration Disorders\t72\t94.66049887893593\nCough\tAltitude Sickness\t5\t6.573645755481662\nCough\tApnea\t9\t11.83256235986699\nCough\tSleep Apnea Syndromes\t13\t17.09147896425232\nCough\tSleep Apnea, Central\t1\t1.3147291510963324\nCough\tSleep Apnea, Obstructive\t5\t6.573645755481662\nCough\tCough\t4598\t6045.124636740937\nCough\tDyspnea\t155\t203.78301841993152\nCough\tDyspnea, Paroxysmal\t2\t2.6294583021926647\nCough\tHyperventilation\t10\t13.147291510963324\nCough\tMouth Breathing\t2\t2.6294583021926647\nCough\tRespiratory Aspiration\t13\t17.09147896425232\nCough\tRespiratory Insufficiency\t60\t78.88374906577994\nCough\tAirway Obstruction\t70\t92.03104057674327\nCough\tHypoventilation\t2\t2.6294583021926647\nCough\tRespiratory Paralysis\t4\t5.2589166043853295\nCough\tRespiratory Hypersensitivity\t52\t68.36591585700928\nCough\tRespiratory System Abnormalities\t1\t1.3147291510963324\nCough\tBronchopulmonary Sequestration\t4\t5.2589166043853295\nCough\tRespiratory Tract Fistula\t3\t3.944187453288997\nCough\tEpiglottitis\t4\t5.2589166043853295\nCough\tTracheitis\t10\t13.147291510963324\nCough\tThoracic Diseases\t7\t9.203104057674327\nCough\tMediastinal Diseases\t8\t10.517833208770659\nCough\tMediastinal Emphysema\t20\t26.29458302192665\nCough\tMediastinitis\t1\t1.3147291510963324\nCough\tTracheal Diseases\t52\t68.36591585700928\nCough\tTracheal Stenosis\t14\t18.406208115348655\nCough\tEar Diseases\t1\t1.3147291510963324\nCough\tEarache\t2\t2.6294583021926647\nCough\tHearing Loss, Bilateral\t1\t1.3147291510963324\nCough\tHearing Loss, Functional\t1\t1.3147291510963324\nCough\tLabyrinth Diseases\t1\t1.3147291510963324\nCough\tVertigo\t1\t1.3147291510963324\nCough\tOtitis\t1\t1.3147291510963324\nCough\tOtitis Externa\t1\t1.3147291510963324\nCough\tOtitis Media\t5\t6.573645755481662\nCough\tOtitis Media with Effusion\t1\t1.3147291510963324\nCough\tMultiple Sclerosis\t6\t7.888374906577994\nCough\tMyasthenia Gravis\t1\t1.3147291510963324\nCough\tGuillain-Barre Syndrome\t2\t2.6294583021926647\nCough\tHereditary Sensory and Autonomic Neuropathies\t3\t3.944187453288997\nCough\tGiant Cell Arteritis\t26\t34.18295792850464\nCough\tAutonomic Nervous System Diseases\t4\t5.2589166043853295\nCough\tAdie Syndrome\t4\t5.2589166043853295\nCough\tHypotension, Orthostatic\t1\t1.3147291510963324\nCough\tSyncope, Vasovagal\t2\t2.6294583021926647\nCough\tCentral Nervous System Diseases\t1\t1.3147291510963324\nCough\tBrain Diseases\t3\t3.944187453288997\nCough\tParkinson Disease\t11\t14.462020662059656\nCough\tParkinson Disease, Postencephalitic\t1\t1.3147291510963324\nCough\tSupranuclear Palsy, Progressive\t1\t1.3147291510963324\nCough\tTourette Syndrome\t4\t5.2589166043853295\nCough\tCerebral Palsy\t4\t5.2589166043853295\nCough\tBrain Death\t1\t1.3147291510963324\nCough\tBrain Diseases, Metabolic, Inborn\t1\t1.3147291510963324\nCough\tGlycogen Storage Disease Type II\t2\t2.6294583021926647\nCough\tNiemann-Pick Disease, Type B\t1\t1.3147291510963324\nCough\tBrain Edema\t1\t1.3147291510963324\nCough\tBrain Injuries\t2\t2.6294583021926647\nCough\tPneumocephalus\t3\t3.944187453288997\nCough\tCerebellar Diseases\t1\t1.3147291510963324\nCough\tCerebellar Ataxia\t1\t1.3147291510963324\nCough\tAtaxia Telangiectasia\t1\t1.3147291510963324\nCough\tCerebrovascular Disorders\t7\t9.203104057674327\nCough\tBrain Ischemia\t3\t3.944187453288997\nCough\tBrain Infarction\t1\t1.3147291510963324\nCough\tBrain Stem Infarctions\t1\t1.3147291510963324\nCough\tLateral Medullary Syndrome\t1\t1.3147291510963324\nCough\tCerebral Infarction\t18\t23.66512471973398\nCough\tInfarction, Middle Cerebral Artery\t1\t1.3147291510963324\nCough\tIschemic Attack, Transient\t1\t1.3147291510963324\nCough\tCarotid Artery Diseases\t4\t5.2589166043853295\nCough\tCarotid Artery Thrombosis\t1\t1.3147291510963324\nCough\tCarotid Stenosis\t1\t1.3147291510963324\nCough\tVertebral Artery Dissection\t1\t1.3147291510963324\nCough\tIntracranial Aneurysm\t2\t2.6294583021926647\nCough\tIntracranial Arteriosclerosis\t1\t1.3147291510963324\nCough\tIntracranial Arteriovenous Malformations\t1\t1.3147291510963324\nCough\tIntracranial Embolism and Thrombosis\t2\t2.6294583021926647\nCough\tIntracranial Embolism\t3\t3.944187453288997\nCough\tCerebral Hemorrhage\t4\t5.2589166043853295\nCough\tHematoma, Epidural, Cranial\t2\t2.6294583021926647\nCough\tHematoma, Subdural\t2\t2.6294583021926647\nCough\tSubarachnoid Hemorrhage\t2\t2.6294583021926647\nCough\tStroke\t15\t19.720937266444984\nCough\tVascular Headaches\t1\t1.3147291510963324\nCough\tDementia\t1\t1.3147291510963324\nCough\tCreutzfeldt-Jakob Syndrome\t2\t2.6294583021926647\nCough\tMeningoencephalitis\t2\t2.6294583021926647\nCough\tEpilepsy\t11\t14.462020662059656\nCough\tEpilepsies, Partial\t3\t3.944187453288997\nCough\tEpilepsy, Temporal Lobe\t3\t3.944187453288997\nCough\tSeizures\t10\t13.147291510963324\nCough\tHeadache Disorders\t1\t1.3147291510963324\nCough\tHeadache Disorders, Primary\t2\t2.6294583021926647\nCough\tMigraine Disorders\t4\t5.2589166043853295\nCough\tMigraine without Aura\t1\t1.3147291510963324\nCough\tTension-Type Headache\t1\t1.3147291510963324\nCough\tCluster Headache\t2\t2.6294583021926647\nCough\tParoxysmal Hemicrania\t1\t1.3147291510963324\nCough\tHydrocephalus\t4\t5.2589166043853295\nCough\tHypoxia, Brain\t2\t2.6294583021926647\nCough\tIntracranial Hypertension\t1\t1.3147291510963324\nCough\tHypertensive Encephalopathy\t1\t1.3147291510963324\nCough\tPseudotumor Cerebri\t2\t2.6294583021926647\nCough\tIntracranial Hypotension\t2\t2.6294583021926647\nCough\tSubdural Effusion\t1\t1.3147291510963324\nCough\tMovement Disorders\t2\t2.6294583021926647\nCough\tDyskinesias\t1\t1.3147291510963324\nCough\tTorticollis\t2\t2.6294583021926647\nCough\tEssential Tremor\t1\t1.3147291510963324\nCough\tTic Disorders\t8\t10.517833208770659\nCough\tSpinal Cord Diseases\t2\t2.6294583021926647\nCough\tAmyotrophic Lateral Sclerosis\t18\t23.66512471973398\nCough\tMuscular Atrophy, Spinal\t1\t1.3147291510963324\nCough\tSpinal Muscular Atrophies of Childhood\t3\t3.944187453288997\nCough\tSpinal Cord Injuries\t18\t23.66512471973398\nCough\tSyringomyelia\t5\t6.573645755481662\nCough\tCranial Nerve Diseases\t2\t2.6294583021926647\nCough\tHypoglossal Nerve Diseases\t1\t1.3147291510963324\nCough\tNystagmus, Pathologic\t2\t2.6294583021926647\nCough\tOptic Nerve Diseases\t2\t2.6294583021926647\nCough\tOptic Neuritis\t1\t1.3147291510963324\nCough\tTrigeminal Neuralgia\t1\t1.3147291510963324\nCough\tVagus Nerve Diseases\t6\t7.888374906577994\nCough\tHereditary Sensory and Motor Neuropathy\t3\t3.944187453288997\nCough\tArnold-Chiari Malformation\t14\t18.406208115348655\nCough\tMeningocele\t1\t1.3147291510963324\nCough\tMotor Neuron Disease\t3\t3.944187453288997\nCough\tBulbar Palsy, Progressive\t2\t2.6294583021926647\nCough\tDecerebrate State\t8\t10.517833208770659\nCough\tDystonia\t1\t1.3147291510963324\nCough\tMyoclonus\t1\t1.3147291510963324\nCough\tPsychomotor Agitation\t1\t1.3147291510963324\nCough\tTics\t1\t1.3147291510963324\nCough\tLanguage Disorders\t1\t1.3147291510963324\nCough\tSpeech Disorders\t1\t1.3147291510963324\nCough\tMutism\t1\t1.3147291510963324\nCough\tConfusion\t2\t2.6294583021926647\nCough\tDelirium\t1\t1.3147291510963324\nCough\tConsciousness Disorders\t6\t7.888374906577994\nCough\tUnconsciousness\t2\t2.6294583021926647\nCough\tComa\t3\t3.944187453288997\nCough\tSyncope\t110\t144.62020662059655\nCough\tMemory Disorders\t1\t1.3147291510963324\nCough\tAmnesia\t1\t1.3147291510963324\nCough\tMental Retardation\t1\t1.3147291510963324\nCough\tDown Syndrome\t3\t3.944187453288997\nCough\tHallucinations\t2\t2.6294583021926647\nCough\tNeurogenic Inflammation\t1\t1.3147291510963324\nCough\tMuscular Atrophy\t1\t1.3147291510963324\nCough\tSpasm\t1\t1.3147291510963324\nCough\tPain\t30\t39.44187453288997\nCough\tBack Pain\t4\t5.2589166043853295\nCough\tHeadache\t43\t56.53335349714229\nCough\tNeck Pain\t1\t1.3147291510963324\nCough\tSciatica\t1\t1.3147291510963324\nCough\tParalysis\t2\t2.6294583021926647\nCough\tHemiplegia\t2\t2.6294583021926647\nCough\tParaplegia\t4\t5.2589166043853295\nCough\tQuadriplegia\t14\t18.406208115348655\nCough\tTonic Pupil\t2\t2.6294583021926647\nCough\tSensation Disorders\t1\t1.3147291510963324\nCough\tDizziness\t3\t3.944187453288997\nCough\tOlfaction Disorders\t1\t1.3147291510963324\nCough\tParesthesia\t1\t1.3147291510963324\nCough\tDysgeusia\t1\t1.3147291510963324\nCough\tVision Disorders\t1\t1.3147291510963324\nCough\tBlindness\t4\t5.2589166043853295\nCough\tNeuromuscular Diseases\t36\t47.33024943946796\nCough\tPeripheral Nervous System Diseases\t4\t5.2589166043853295\nCough\tDiabetic Neuropathies\t7\t9.203104057674327\nCough\tMononeuropathies\t1\t1.3147291510963324\nCough\tNerve Compression Syndromes\t4\t5.2589166043853295\nCough\tThoracic Outlet Syndrome\t1\t1.3147291510963324\nCough\tNeuritis\t1\t1.3147291510963324\nCough\tPOEMS Syndrome\t1\t1.3147291510963324\nCough\tNeurotoxicity Syndromes\t1\t1.3147291510963324\nCough\tArsenic Poisoning\t2\t2.6294583021926647\nCough\tSleep Disorders\t7\t9.203104057674327\nCough\tSleep Initiation and Maintenance Disorders\t4\t5.2589166043853295\nCough\tCraniocerebral Trauma\t4\t5.2589166043853295\nCough\tShaken Baby Syndrome\t1\t1.3147291510963324\nCough\tSkull Fractures\t1\t1.3147291510963324\nCough\tConjunctival Diseases\t1\t1.3147291510963324\nCough\tConjunctivitis\t4\t5.2589166043853295\nCough\tConjunctivitis, Allergic\t1\t1.3147291510963324\nCough\tKeratitis\t1\t1.3147291510963324\nCough\tChoroid Hemorrhage\t1\t1.3147291510963324\nCough\tRetinal Hemorrhage\t3\t3.944187453288997\nCough\tEyelid Diseases\t1\t1.3147291510963324\nCough\tBlepharoptosis\t1\t1.3147291510963324\nCough\tLacrimal Apparatus Diseases\t2\t2.6294583021926647\nCough\tGlaucoma\t3\t3.944187453288997\nCough\tGlaucoma, Open-Angle\t1\t1.3147291510963324\nCough\tOcular Hypotension\t1\t1.3147291510963324\nCough\tOrbital Diseases\t3\t3.944187453288997\nCough\tExophthalmos\t2\t2.6294583021926647\nCough\tMyopia\t1\t1.3147291510963324\nCough\tDiabetic Retinopathy\t1\t1.3147291510963324\nCough\tIris Diseases\t1\t1.3147291510963324\nCough\tGenital Diseases, Male\t1\t1.3147291510963324\nCough\tHemospermia\t1\t1.3147291510963324\nCough\tProstatic Hyperplasia\t2\t2.6294583021926647\nCough\tUrologic Diseases\t1\t1.3147291510963324\nCough\tKidney Diseases\t2\t2.6294583021926647\nCough\tDiabetes Insipidus\t1\t1.3147291510963324\nCough\tDiabetes Insipidus, Neurogenic\t1\t1.3147291510963324\nCough\tDiabetic Nephropathies\t1\t1.3147291510963324\nCough\tGlomerulonephritis\t2\t2.6294583021926647\nCough\tGlomerulonephritis, Membranoproliferative\t1\t1.3147291510963324\nCough\tNephrotic Syndrome\t2\t2.6294583021926647\nCough\tRenal Artery Obstruction\t1\t1.3147291510963324\nCough\tRenal Insufficiency\t1\t1.3147291510963324\nCough\tAcute Kidney Injury\t4\t5.2589166043853295\nCough\tKidney Failure, Chronic\t6\t7.888374906577994\nCough\tUrethral Diseases\t1\t1.3147291510963324\nCough\tUrinary Bladder Neck Obstruction\t1\t1.3147291510963324\nCough\tUrinary Bladder, Overactive\t2\t2.6294583021926647\nCough\tUrination Disorders\t6\t7.888374906577994\nCough\tHematuria\t1\t1.3147291510963324\nCough\tOliguria\t1\t1.3147291510963324\nCough\tAlbuminuria\t2\t2.6294583021926647\nCough\tUrinary Incontinence\t28\t36.81241623069731\nCough\tUrinary Incontinence, Stress\t99\t130.1581859585369\nCough\tUrinary Incontinence, Urge\t1\t1.3147291510963324\nCough\tFemale Urogenital Diseases\t1\t1.3147291510963324\nCough\tFallopian Tube Diseases\t1\t1.3147291510963324\nCough\tAnovulation\t1\t1.3147291510963324\nCough\tOvarian Hyperstimulation Syndrome\t1\t1.3147291510963324\nCough\tEndometriosis\t4\t5.2589166043853295\nCough\tInfertility, Female\t1\t1.3147291510963324\nCough\tUterine Cervical Incompetence\t1\t1.3147291510963324\nCough\tUterine Prolapse\t4\t5.2589166043853295\nCough\tVaginal Diseases\t2\t2.6294583021926647\nCough\tPregnancy Complications\t5\t6.573645755481662\nCough\tAbruptio Placentae\t1\t1.3147291510963324\nCough\tFetal Membranes, Premature Rupture\t1\t1.3147291510963324\nCough\tPregnancy Complications, Cardiovascular\t1\t1.3147291510963324\nCough\tPregnancy in Diabetics\t1\t1.3147291510963324\nCough\tPuerperal Disorders\t3\t3.944187453288997\nCough\tCardiovascular Abnormalities\t2\t2.6294583021926647\nCough\tHeart Defects, Congenital\t1\t1.3147291510963324\nCough\tCoronary Vessel Anomalies\t1\t1.3147291510963324\nCough\tHeart Septal Defects\t1\t1.3147291510963324\nCough\tHeart Septal Defects, Atrial\t11\t14.462020662059656\nCough\tHeart Septal Defects, Ventricular\t1\t1.3147291510963324\nCough\tTetralogy of Fallot\t1\t1.3147291510963324\nCough\tTransposition of Great Vessels\t1\t1.3147291510963324\nCough\tVascular Malformations\t1\t1.3147291510963324\nCough\tArteriovenous Malformations\t2\t2.6294583021926647\nCough\tVascular Fistula\t1\t1.3147291510963324\nCough\tArterio-Arterial Fistula\t1\t1.3147291510963324\nCough\tHeart Diseases\t11\t14.462020662059656\nCough\tArrhythmias, Cardiac\t15\t19.720937266444984\nCough\tSick Sinus Syndrome\t1\t1.3147291510963324\nCough\tAtrial Fibrillation\t3\t3.944187453288997\nCough\tBradycardia\t1\t1.3147291510963324\nCough\tAtrial Premature Complexes\t3\t3.944187453288997\nCough\tVentricular Premature Complexes\t4\t5.2589166043853295\nCough\tHeart Block\t8\t10.517833208770659\nCough\tAtrioventricular Block\t3\t3.944187453288997\nCough\tLong QT Syndrome\t2\t2.6294583021926647\nCough\tTachycardia\t8\t10.517833208770659\nCough\tTachycardia, Paroxysmal\t1\t1.3147291510963324\nCough\tTachycardia, Supraventricular\t2\t2.6294583021926647\nCough\tTachycardia, Ectopic Atrial\t1\t1.3147291510963324\nCough\tTachycardia, Ventricular\t2\t2.6294583021926647\nCough\tTorsades de Pointes\t1\t1.3147291510963324\nCough\tVentricular Fibrillation\t11\t14.462020662059656\nCough\tCardiac Output, Low\t3\t3.944187453288997\nCough\tCardiac Tamponade\t1\t1.3147291510963324\nCough\tCardiomegaly\t1\t1.3147291510963324\nCough\tHypertrophy, Left Ventricular\t2\t2.6294583021926647\nCough\tHypertrophy, Right Ventricular\t1\t1.3147291510963324\nCough\tCardiomyopathies\t4\t5.2589166043853295\nCough\tCardiomyopathy, Hypertrophic\t2\t2.6294583021926647\nCough\tCardiomyopathy, Restrictive\t1\t1.3147291510963324\nCough\tMyocardial Reperfusion Injury\t1\t1.3147291510963324\nCough\tMyocarditis\t4\t5.2589166043853295\nCough\tHeart Arrest\t11\t14.462020662059656\nCough\tHeart Failure\t31\t40.756603683986306\nCough\tAortic Valve Insufficiency\t2\t2.6294583021926647\nCough\tMitral Valve Prolapse\t1\t1.3147291510963324\nCough\tMitral Valve Insufficiency\t1\t1.3147291510963324\nCough\tMitral Valve Stenosis\t4\t5.2589166043853295\nCough\tTricuspid Valve Stenosis\t1\t1.3147291510963324\nCough\tMyocardial Ischemia\t2\t2.6294583021926647\nCough\tAngina Pectoris\t2\t2.6294583021926647\nCough\tAngina, Unstable\t1\t1.3147291510963324\nCough\tCoronary Disease\t7\t9.203104057674327\nCough\tCoronary Artery Disease\t7\t9.203104057674327\nCough\tMyocardial Infarction\t13\t17.09147896425232\nCough\tShock, Cardiogenic\t2\t2.6294583021926647\nCough\tPericardial Effusion\t3\t3.944187453288997\nCough\tPericarditis\t6\t7.888374906577994\nCough\tPericarditis, Constrictive\t3\t3.944187453288997\nCough\tPneumopericardium\t3\t3.944187453288997\nCough\tPulmonary Heart Disease\t6\t7.888374906577994\nCough\tVentricular Dysfunction, Left\t5\t6.573645755481662\nCough\tTakotsubo Cardiomyopathy\t1\t1.3147291510963324\nCough\tVentricular Outflow Obstruction\t1\t1.3147291510963324\nCough\tVascular Diseases\t2\t2.6294583021926647\nCough\tAneurysm\t5\t6.573645755481662\nCough\tAneurysm, Dissecting\t4\t5.2589166043853295\nCough\tAneurysm, False\t5\t6.573645755481662\nCough\tAneurysm, Ruptured\t2\t2.6294583021926647\nCough\tAortic Rupture\t3\t3.944187453288997\nCough\tAortic Aneurysm\t3\t3.944187453288997\nCough\tAortic Aneurysm, Thoracic\t9\t11.83256235986699\nCough\tAngioedema\t9\t11.83256235986699\nCough\tAortic Diseases\t1\t1.3147291510963324\nCough\tAortitis\t2\t2.6294583021926647\nCough\tArterial Occlusive Diseases\t4\t5.2589166043853295\nCough\tArteriosclerosis\t1\t1.3147291510963324\nCough\tArteritis\t2\t2.6294583021926647\nCough\tDiabetic Angiopathies\t1\t1.3147291510963324\nCough\tDiabetic Foot\t1\t1.3147291510963324\nCough\tEmbolism\t3\t3.944187453288997\nCough\tEmbolism, Air\t13\t17.09147896425232\nCough\tEmbolism, Fat\t1\t1.3147291510963324\nCough\tEmbolism, Paradoxical\t2\t2.6294583021926647\nCough\tVenous Thromboembolism\t1\t1.3147291510963324\nCough\tThrombosis\t3\t3.944187453288997\nCough\tVenous Thrombosis\t1\t1.3147291510963324\nCough\tThrombophlebitis\t3\t3.944187453288997\nCough\tEhlers-Danlos Syndrome\t2\t2.6294583021926647\nCough\tHypertension\t93\t122.26981105195891\nCough\tHypotension\t7\t9.203104057674327\nCough\tSuperior Vena Cava Syndrome\t4\t5.2589166043853295\nCough\tVaricose Veins\t3\t3.944187453288997\nCough\tVasculitis\t3\t3.944187453288997\nCough\tMucocutaneous Lymph Node Syndrome\t7\t9.203104057674327\nCough\tPurpura, Schoenlein-Henoch\t1\t1.3147291510963324\nCough\tChurg-Strauss Syndrome\t3\t3.944187453288997\nCough\tVasculitis, Leukocytoclastic, Cutaneous\t2\t2.6294583021926647\nCough\tVenous Insufficiency\t2\t2.6294583021926647\nCough\tHematologic Diseases\t1\t1.3147291510963324\nCough\tAnemia\t5\t6.573645755481662\nCough\tAnemia, Aplastic\t1\t1.3147291510963324\nCough\tAnemia, Sickle Cell\t13\t17.09147896425232\nCough\tSickle Cell Trait\t1\t1.3147291510963324\nCough\tbeta-Thalassemia\t2\t2.6294583021926647\nCough\tAnemia, Pernicious\t1\t1.3147291510963324\nCough\tAnemia, Refractory\t1\t1.3147291510963324\nCough\tBlood Coagulation Disorders\t1\t1.3147291510963324\nCough\tHemophilia A\t1\t1.3147291510963324\nCough\tWiskott-Aldrich Syndrome\t1\t1.3147291510963324\nCough\tEcchymosis\t2\t2.6294583021926647\nCough\tPurpura\t3\t3.944187453288997\nCough\tThrombocytopenia\t1\t1.3147291510963324\nCough\tAgammaglobulinemia\t2\t2.6294583021926647\nCough\tIgG Deficiency\t1\t1.3147291510963324\nCough\tMyelodysplastic Syndromes\t1\t1.3147291510963324\nCough\tPolycythemia Vera\t3\t3.944187453288997\nCough\tEosinophilia\t48\t63.10699925262395\nCough\tAngiolymphoid Hyperplasia with Eosinophilia\t2\t2.6294583021926647\nCough\tHypereosinophilic Syndrome\t6\t7.888374906577994\nCough\tLeukocytosis\t3\t3.944187453288997\nCough\tLymphocytosis\t2\t2.6294583021926647\nCough\tChediak-Higashi Syndrome\t1\t1.3147291510963324\nCough\tGranulomatous Disease, Chronic\t2\t2.6294583021926647\nCough\tJobs Syndrome    0.0000000000
    ## Mandibular Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      0.0018658317
    ##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Uterine Cervical Diseases
    ## Lupus Nephritis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    0.0007900049
    ## Uterine Cervical Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1.0000000000
    ## Tuberculosis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       0.0022674518
    ## Silo Fillers Disease\t1\t1.3147291510963324\nCough\tAnti-Glomerular Basement Membrane Disease\t3\t3.944187453288997\nCough\tHistiocytosis, Langerhans-Cell\t10\t13.147291510963324\nCough\tIdiopathic Pulmonary Fibrosis\t29\t38.12714538179364\nCough\tPneumoconiosis\t19\t24.979853870830315\nCough\tAsbestosis\t9\t11.83256235986699\nCough\tByssinosis\t4\t5.2589166043853295\nCough\tSilicosis\t8\t10.517833208770659\nCough\tSarcoidosis, Pulmonary\t20\t26.29458302192665\nCough\tWegener Granulomatosis\t9\t11.83256235986699\nCough\tLung Diseases, Obstructive\t93\t122.26981105195891\nCough\tPulmonary Disease, Chronic Obstructive\t90\t118.3256235986699\nCough\tLung Injury\t1\t1.3147291510963324\nCough\tMeconium Aspiration Syndrome\t1\t1.3147291510963324\nCough\tBronchopulmonary Dysplasia\t2\t2.6294583021926647\nCough\tPneumonia\t95\t124.89926935415157\nCough\tPleuropneumonia\t1\t1.3147291510963324\nCough\tPneumonia, Aspiration\t35\t46.01552028837163\nCough\tPneumonia, Lipid\t5\t6.573645755481662\nCough\tPulmonary Alveolar Proteinosis\t7\t9.203104057674327\nCough\tPulmonary Atelectasis\t20\t26.29458302192665\nCough\tMiddle Lobe Syndrome\t5\t6.573645755481662\nCough\tPulmonary Edema\t21\t27.60931217302298\nCough\tPulmonary Embolism\t22\t28.92404132411931\nCough\tPulmonary Emphysema\t31\t40.756603683986306\nCough\tLung, Hyperlucent\t1\t1.3147291510963324\nCough\tPulmonary Eosinophilia\t30\t39.44187453288997\nCough\tPulmonary Fibrosis\t27\t35.49768707960097\nCough\tPulmonary Veno-Occlusive Disease\t1\t1.3147291510963324\nCough\tRespiratory Distress Syndrome, Adult\t8\t10.517833208770659\nCough\tRespiratory Distress Syndrome, Newborn\t6\t7.888374906577994\nCough\tScimitar Syndrome\t2\t2.6294583021926647\nCough\tNose Diseases\t6\t7.888374906577994\nCough\tEpistaxis\t2\t2.6294583021926647\nCough\tNasal Obstruction\t4\t5.2589166043853295\nCough\tNasal Polyps\t1\t1.3147291510963324\nCough\tParanasal Sinus Diseases\t3\t3.944187453288997\nCough\tSinusitis\t46\t60.47754095043129\nCough\tMaxillary Sinusitis\t2\t2.6294583021926647\nCough\tRhinitis\t54\t70.99537415920194\nCough\tRhinitis, Allergic, Perennial\t18\t23.66512471973398\nCough\tRhinitis, Allergic, Seasonal\t24\t31.553499626311975\nCough\tRhinitis, Atrophic\t1\t1.3147291510963324\nCough\tRhinitis, Vasomotor\t1\t1.3147291510963324\nCough\tPleural Diseases\t11\t14.462020662059656\nCough\tChylothorax\t1\t1.3147291510963324\nCough\tHydrothorax\t2\t2.6294583021926647\nCough\tPleural Effusion\t21\t27.60931217302298\nCough\tPleurisy\t9\t11.83256235986699\nCough\tPneumothorax\t23\t30.238770475215645\nCough\tRespiration Disorders\t72\t94.66049887893593\nCough\tAltitude Sickness\t5\t6.573645755481662\nCough\tApnea\t9\t11.83256235986699\nCough\tSleep Apnea Syndromes\t13\t17.09147896425232\nCough\tSleep Apnea, Central\t1\t1.3147291510963324\nCough\tSleep Apnea, Obstructive\t5\t6.573645755481662\nCough\tCough\t4598\t6045.124636740937\nCough\tDyspnea\t155\t203.78301841993152\nCough\tDyspnea, Paroxysmal\t2\t2.6294583021926647\nCough\tHyperventilation\t10\t13.147291510963324\nCough\tMouth Breathing\t2\t2.6294583021926647\nCough\tRespiratory Aspiration\t13\t17.09147896425232\nCough\tRespiratory Insufficiency\t60\t78.88374906577994\nCough\tAirway Obstruction\t70\t92.03104057674327\nCough\tHypoventilation\t2\t2.6294583021926647\nCough\tRespiratory Paralysis\t4\t5.2589166043853295\nCough\tRespiratory Hypersensitivity\t52\t68.36591585700928\nCough\tRespiratory System Abnormalities\t1\t1.3147291510963324\nCough\tBronchopulmonary Sequestration\t4\t5.2589166043853295\nCough\tRespiratory Tract Fistula\t3\t3.944187453288997\nCough\tEpiglottitis\t4\t5.2589166043853295\nCough\tTracheitis\t10\t13.147291510963324\nCough\tThoracic Diseases\t7\t9.203104057674327\nCough\tMediastinal Diseases\t8\t10.517833208770659\nCough\tMediastinal Emphysema\t20\t26.29458302192665\nCough\tMediastinitis\t1\t1.3147291510963324\nCough\tTracheal Diseases\t52\t68.36591585700928\nCough\tTracheal Stenosis\t14\t18.406208115348655\nCough\tEar Diseases\t1\t1.3147291510963324\nCough\tEarache\t2\t2.6294583021926647\nCough\tHearing Loss, Bilateral\t1\t1.3147291510963324\nCough\tHearing Loss, Functional\t1\t1.3147291510963324\nCough\tLabyrinth Diseases\t1\t1.3147291510963324\nCough\tVertigo\t1\t1.3147291510963324\nCough\tOtitis\t1\t1.3147291510963324\nCough\tOtitis Externa\t1\t1.3147291510963324\nCough\tOtitis Media\t5\t6.573645755481662\nCough\tOtitis Media with Effusion\t1\t1.3147291510963324\nCough\tMultiple Sclerosis\t6\t7.888374906577994\nCough\tMyasthenia Gravis\t1\t1.3147291510963324\nCough\tGuillain-Barre Syndrome\t2\t2.6294583021926647\nCough\tHereditary Sensory and Autonomic Neuropathies\t3\t3.944187453288997\nCough\tGiant Cell Arteritis\t26\t34.18295792850464\nCough\tAutonomic Nervous System Diseases\t4\t5.2589166043853295\nCough\tAdie Syndrome\t4\t5.2589166043853295\nCough\tHypotension, Orthostatic\t1\t1.3147291510963324\nCough\tSyncope, Vasovagal\t2\t2.6294583021926647\nCough\tCentral Nervous System Diseases\t1\t1.3147291510963324\nCough\tBrain Diseases\t3\t3.944187453288997\nCough\tParkinson Disease\t11\t14.462020662059656\nCough\tParkinson Disease, Postencephalitic\t1\t1.3147291510963324\nCough\tSupranuclear Palsy, Progressive\t1\t1.3147291510963324\nCough\tTourette Syndrome\t4\t5.2589166043853295\nCough\tCerebral Palsy\t4\t5.2589166043853295\nCough\tBrain Death\t1\t1.3147291510963324\nCough\tBrain Diseases, Metabolic, Inborn\t1\t1.3147291510963324\nCough\tGlycogen Storage Disease Type II\t2\t2.6294583021926647\nCough\tNiemann-Pick Disease, Type B\t1\t1.3147291510963324\nCough\tBrain Edema\t1\t1.3147291510963324\nCough\tBrain Injuries\t2\t2.6294583021926647\nCough\tPneumocephalus\t3\t3.944187453288997\nCough\tCerebellar Diseases\t1\t1.3147291510963324\nCough\tCerebellar Ataxia\t1\t1.3147291510963324\nCough\tAtaxia Telangiectasia\t1\t1.3147291510963324\nCough\tCerebrovascular Disorders\t7\t9.203104057674327\nCough\tBrain Ischemia\t3\t3.944187453288997\nCough\tBrain Infarction\t1\t1.3147291510963324\nCough\tBrain Stem Infarctions\t1\t1.3147291510963324\nCough\tLateral Medullary Syndrome\t1\t1.3147291510963324\nCough\tCerebral Infarction\t18\t23.66512471973398\nCough\tInfarction, Middle Cerebral Artery\t1\t1.3147291510963324\nCough\tIschemic Attack, Transient\t1\t1.3147291510963324\nCough\tCarotid Artery Diseases\t4\t5.2589166043853295\nCough\tCarotid Artery Thrombosis\t1\t1.3147291510963324\nCough\tCarotid Stenosis\t1\t1.3147291510963324\nCough\tVertebral Artery Dissection\t1\t1.3147291510963324\nCough\tIntracranial Aneurysm\t2\t2.6294583021926647\nCough\tIntracranial Arteriosclerosis\t1\t1.3147291510963324\nCough\tIntracranial Arteriovenous Malformations\t1\t1.3147291510963324\nCough\tIntracranial Embolism and Thrombosis\t2\t2.6294583021926647\nCough\tIntracranial Embolism\t3\t3.944187453288997\nCough\tCerebral Hemorrhage\t4\t5.2589166043853295\nCough\tHematoma, Epidural, Cranial\t2\t2.6294583021926647\nCough\tHematoma, Subdural\t2\t2.6294583021926647\nCough\tSubarachnoid Hemorrhage\t2\t2.6294583021926647\nCough\tStroke\t15\t19.720937266444984\nCough\tVascular Headaches\t1\t1.3147291510963324\nCough\tDementia\t1\t1.3147291510963324\nCough\tCreutzfeldt-Jakob Syndrome\t2\t2.6294583021926647\nCough\tMeningoencephalitis\t2\t2.6294583021926647\nCough\tEpilepsy\t11\t14.462020662059656\nCough\tEpilepsies, Partial\t3\t3.944187453288997\nCough\tEpilepsy, Temporal Lobe\t3\t3.944187453288997\nCough\tSeizures\t10\t13.147291510963324\nCough\tHeadache Disorders\t1\t1.3147291510963324\nCough\tHeadache Disorders, Primary\t2\t2.6294583021926647\nCough\tMigraine Disorders\t4\t5.2589166043853295\nCough\tMigraine without Aura\t1\t1.3147291510963324\nCough\tTension-Type Headache\t1\t1.3147291510963324\nCough\tCluster Headache\t2\t2.6294583021926647\nCough\tParoxysmal Hemicrania\t1\t1.3147291510963324\nCough\tHydrocephalus\t4\t5.2589166043853295\nCough\tHypoxia, Brain\t2\t2.6294583021926647\nCough\tIntracranial Hypertension\t1\t1.3147291510963324\nCough\tHypertensive Encephalopathy\t1\t1.3147291510963324\nCough\tPseudotumor Cerebri\t2\t2.6294583021926647\nCough\tIntracranial Hypotension\t2\t2.6294583021926647\nCough\tSubdural Effusion\t1\t1.3147291510963324\nCough\tMovement Disorders\t2\t2.6294583021926647\nCough\tDyskinesias\t1\t1.3147291510963324\nCough\tTorticollis\t2\t2.6294583021926647\nCough\tEssential Tremor\t1\t1.3147291510963324\nCough\tTic Disorders\t8\t10.517833208770659\nCough\tSpinal Cord Diseases\t2\t2.6294583021926647\nCough\tAmyotrophic Lateral Sclerosis\t18\t23.66512471973398\nCough\tMuscular Atrophy, Spinal\t1\t1.3147291510963324\nCough\tSpinal Muscular Atrophies of Childhood\t3\t3.944187453288997\nCough\tSpinal Cord Injuries\t18\t23.66512471973398\nCough\tSyringomyelia\t5\t6.573645755481662\nCough\tCranial Nerve Diseases\t2\t2.6294583021926647\nCough\tHypoglossal Nerve Diseases\t1\t1.3147291510963324\nCough\tNystagmus, Pathologic\t2\t2.6294583021926647\nCough\tOptic Nerve Diseases\t2\t2.6294583021926647\nCough\tOptic Neuritis\t1\t1.3147291510963324\nCough\tTrigeminal Neuralgia\t1\t1.3147291510963324\nCough\tVagus Nerve Diseases\t6\t7.888374906577994\nCough\tHereditary Sensory and Motor Neuropathy\t3\t3.944187453288997\nCough\tArnold-Chiari Malformation\t14\t18.406208115348655\nCough\tMeningocele\t1\t1.3147291510963324\nCough\tMotor Neuron Disease\t3\t3.944187453288997\nCough\tBulbar Palsy, Progressive\t2\t2.6294583021926647\nCough\tDecerebrate State\t8\t10.517833208770659\nCough\tDystonia\t1\t1.3147291510963324\nCough\tMyoclonus\t1\t1.3147291510963324\nCough\tPsychomotor Agitation\t1\t1.3147291510963324\nCough\tTics\t1\t1.3147291510963324\nCough\tLanguage Disorders\t1\t1.3147291510963324\nCough\tSpeech Disorders\t1\t1.3147291510963324\nCough\tMutism\t1\t1.3147291510963324\nCough\tConfusion\t2\t2.6294583021926647\nCough\tDelirium\t1\t1.3147291510963324\nCough\tConsciousness Disorders\t6\t7.888374906577994\nCough\tUnconsciousness\t2\t2.6294583021926647\nCough\tComa\t3\t3.944187453288997\nCough\tSyncope\t110\t144.62020662059655\nCough\tMemory Disorders\t1\t1.3147291510963324\nCough\tAmnesia\t1\t1.3147291510963324\nCough\tMental Retardation\t1\t1.3147291510963324\nCough\tDown Syndrome\t3\t3.944187453288997\nCough\tHallucinations\t2\t2.6294583021926647\nCough\tNeurogenic Inflammation\t1\t1.3147291510963324\nCough\tMuscular Atrophy\t1\t1.3147291510963324\nCough\tSpasm\t1\t1.3147291510963324\nCough\tPain\t30\t39.44187453288997\nCough\tBack Pain\t4\t5.2589166043853295\nCough\tHeadache\t43\t56.53335349714229\nCough\tNeck Pain\t1\t1.3147291510963324\nCough\tSciatica\t1\t1.3147291510963324\nCough\tParalysis\t2\t2.6294583021926647\nCough\tHemiplegia\t2\t2.6294583021926647\nCough\tParaplegia\t4\t5.2589166043853295\nCough\tQuadriplegia\t14\t18.406208115348655\nCough\tTonic Pupil\t2\t2.6294583021926647\nCough\tSensation Disorders\t1\t1.3147291510963324\nCough\tDizziness\t3\t3.944187453288997\nCough\tOlfaction Disorders\t1\t1.3147291510963324\nCough\tParesthesia\t1\t1.3147291510963324\nCough\tDysgeusia\t1\t1.3147291510963324\nCough\tVision Disorders\t1\t1.3147291510963324\nCough\tBlindness\t4\t5.2589166043853295\nCough\tNeuromuscular Diseases\t36\t47.33024943946796\nCough\tPeripheral Nervous System Diseases\t4\t5.2589166043853295\nCough\tDiabetic Neuropathies\t7\t9.203104057674327\nCough\tMononeuropathies\t1\t1.3147291510963324\nCough\tNerve Compression Syndromes\t4\t5.2589166043853295\nCough\tThoracic Outlet Syndrome\t1\t1.3147291510963324\nCough\tNeuritis\t1\t1.3147291510963324\nCough\tPOEMS Syndrome\t1\t1.3147291510963324\nCough\tNeurotoxicity Syndromes\t1\t1.3147291510963324\nCough\tArsenic Poisoning\t2\t2.6294583021926647\nCough\tSleep Disorders\t7\t9.203104057674327\nCough\tSleep Initiation and Maintenance Disorders\t4\t5.2589166043853295\nCough\tCraniocerebral Trauma\t4\t5.2589166043853295\nCough\tShaken Baby Syndrome\t1\t1.3147291510963324\nCough\tSkull Fractures\t1\t1.3147291510963324\nCough\tConjunctival Diseases\t1\t1.3147291510963324\nCough\tConjunctivitis\t4\t5.2589166043853295\nCough\tConjunctivitis, Allergic\t1\t1.3147291510963324\nCough\tKeratitis\t1\t1.3147291510963324\nCough\tChoroid Hemorrhage\t1\t1.3147291510963324\nCough\tRetinal Hemorrhage\t3\t3.944187453288997\nCough\tEyelid Diseases\t1\t1.3147291510963324\nCough\tBlepharoptosis\t1\t1.3147291510963324\nCough\tLacrimal Apparatus Diseases\t2\t2.6294583021926647\nCough\tGlaucoma\t3\t3.944187453288997\nCough\tGlaucoma, Open-Angle\t1\t1.3147291510963324\nCough\tOcular Hypotension\t1\t1.3147291510963324\nCough\tOrbital Diseases\t3\t3.944187453288997\nCough\tExophthalmos\t2\t2.6294583021926647\nCough\tMyopia\t1\t1.3147291510963324\nCough\tDiabetic Retinopathy\t1\t1.3147291510963324\nCough\tIris Diseases\t1\t1.3147291510963324\nCough\tGenital Diseases, Male\t1\t1.3147291510963324\nCough\tHemospermia\t1\t1.3147291510963324\nCough\tProstatic Hyperplasia\t2\t2.6294583021926647\nCough\tUrologic Diseases\t1\t1.3147291510963324\nCough\tKidney Diseases\t2\t2.6294583021926647\nCough\tDiabetes Insipidus\t1\t1.3147291510963324\nCough\tDiabetes Insipidus, Neurogenic\t1\t1.3147291510963324\nCough\tDiabetic Nephropathies\t1\t1.3147291510963324\nCough\tGlomerulonephritis\t2\t2.6294583021926647\nCough\tGlomerulonephritis, Membranoproliferative\t1\t1.3147291510963324\nCough\tNephrotic Syndrome\t2\t2.6294583021926647\nCough\tRenal Artery Obstruction\t1\t1.3147291510963324\nCough\tRenal Insufficiency\t1\t1.3147291510963324\nCough\tAcute Kidney Injury\t4\t5.2589166043853295\nCough\tKidney Failure, Chronic\t6\t7.888374906577994\nCough\tUrethral Diseases\t1\t1.3147291510963324\nCough\tUrinary Bladder Neck Obstruction\t1\t1.3147291510963324\nCough\tUrinary Bladder, Overactive\t2\t2.6294583021926647\nCough\tUrination Disorders\t6\t7.888374906577994\nCough\tHematuria\t1\t1.3147291510963324\nCough\tOliguria\t1\t1.3147291510963324\nCough\tAlbuminuria\t2\t2.6294583021926647\nCough\tUrinary Incontinence\t28\t36.81241623069731\nCough\tUrinary Incontinence, Stress\t99\t130.1581859585369\nCough\tUrinary Incontinence, Urge\t1\t1.3147291510963324\nCough\tFemale Urogenital Diseases\t1\t1.3147291510963324\nCough\tFallopian Tube Diseases\t1\t1.3147291510963324\nCough\tAnovulation\t1\t1.3147291510963324\nCough\tOvarian Hyperstimulation Syndrome\t1\t1.3147291510963324\nCough\tEndometriosis\t4\t5.2589166043853295\nCough\tInfertility, Female\t1\t1.3147291510963324\nCough\tUterine Cervical Incompetence\t1\t1.3147291510963324\nCough\tUterine Prolapse\t4\t5.2589166043853295\nCough\tVaginal Diseases\t2\t2.6294583021926647\nCough\tPregnancy Complications\t5\t6.573645755481662\nCough\tAbruptio Placentae\t1\t1.3147291510963324\nCough\tFetal Membranes, Premature Rupture\t1\t1.3147291510963324\nCough\tPregnancy Complications, Cardiovascular\t1\t1.3147291510963324\nCough\tPregnancy in Diabetics\t1\t1.3147291510963324\nCough\tPuerperal Disorders\t3\t3.944187453288997\nCough\tCardiovascular Abnormalities\t2\t2.6294583021926647\nCough\tHeart Defects, Congenital\t1\t1.3147291510963324\nCough\tCoronary Vessel Anomalies\t1\t1.3147291510963324\nCough\tHeart Septal Defects\t1\t1.3147291510963324\nCough\tHeart Septal Defects, Atrial\t11\t14.462020662059656\nCough\tHeart Septal Defects, Ventricular\t1\t1.3147291510963324\nCough\tTetralogy of Fallot\t1\t1.3147291510963324\nCough\tTransposition of Great Vessels\t1\t1.3147291510963324\nCough\tVascular Malformations\t1\t1.3147291510963324\nCough\tArteriovenous Malformations\t2\t2.6294583021926647\nCough\tVascular Fistula\t1\t1.3147291510963324\nCough\tArterio-Arterial Fistula\t1\t1.3147291510963324\nCough\tHeart Diseases\t11\t14.462020662059656\nCough\tArrhythmias, Cardiac\t15\t19.720937266444984\nCough\tSick Sinus Syndrome\t1\t1.3147291510963324\nCough\tAtrial Fibrillation\t3\t3.944187453288997\nCough\tBradycardia\t1\t1.3147291510963324\nCough\tAtrial Premature Complexes\t3\t3.944187453288997\nCough\tVentricular Premature Complexes\t4\t5.2589166043853295\nCough\tHeart Block\t8\t10.517833208770659\nCough\tAtrioventricular Block\t3\t3.944187453288997\nCough\tLong QT Syndrome\t2\t2.6294583021926647\nCough\tTachycardia\t8\t10.517833208770659\nCough\tTachycardia, Paroxysmal\t1\t1.3147291510963324\nCough\tTachycardia, Supraventricular\t2\t2.6294583021926647\nCough\tTachycardia, Ectopic Atrial\t1\t1.3147291510963324\nCough\tTachycardia, Ventricular\t2\t2.6294583021926647\nCough\tTorsades de Pointes\t1\t1.3147291510963324\nCough\tVentricular Fibrillation\t11\t14.462020662059656\nCough\tCardiac Output, Low\t3\t3.944187453288997\nCough\tCardiac Tamponade\t1\t1.3147291510963324\nCough\tCardiomegaly\t1\t1.3147291510963324\nCough\tHypertrophy, Left Ventricular\t2\t2.6294583021926647\nCough\tHypertrophy, Right Ventricular\t1\t1.3147291510963324\nCough\tCardiomyopathies\t4\t5.2589166043853295\nCough\tCardiomyopathy, Hypertrophic\t2\t2.6294583021926647\nCough\tCardiomyopathy, Restrictive\t1\t1.3147291510963324\nCough\tMyocardial Reperfusion Injury\t1\t1.3147291510963324\nCough\tMyocarditis\t4\t5.2589166043853295\nCough\tHeart Arrest\t11\t14.462020662059656\nCough\tHeart Failure\t31\t40.756603683986306\nCough\tAortic Valve Insufficiency\t2\t2.6294583021926647\nCough\tMitral Valve Prolapse\t1\t1.3147291510963324\nCough\tMitral Valve Insufficiency\t1\t1.3147291510963324\nCough\tMitral Valve Stenosis\t4\t5.2589166043853295\nCough\tTricuspid Valve Stenosis\t1\t1.3147291510963324\nCough\tMyocardial Ischemia\t2\t2.6294583021926647\nCough\tAngina Pectoris\t2\t2.6294583021926647\nCough\tAngina, Unstable\t1\t1.3147291510963324\nCough\tCoronary Disease\t7\t9.203104057674327\nCough\tCoronary Artery Disease\t7\t9.203104057674327\nCough\tMyocardial Infarction\t13\t17.09147896425232\nCough\tShock, Cardiogenic\t2\t2.6294583021926647\nCough\tPericardial Effusion\t3\t3.944187453288997\nCough\tPericarditis\t6\t7.888374906577994\nCough\tPericarditis, Constrictive\t3\t3.944187453288997\nCough\tPneumopericardium\t3\t3.944187453288997\nCough\tPulmonary Heart Disease\t6\t7.888374906577994\nCough\tVentricular Dysfunction, Left\t5\t6.573645755481662\nCough\tTakotsubo Cardiomyopathy\t1\t1.3147291510963324\nCough\tVentricular Outflow Obstruction\t1\t1.3147291510963324\nCough\tVascular Diseases\t2\t2.6294583021926647\nCough\tAneurysm\t5\t6.573645755481662\nCough\tAneurysm, Dissecting\t4\t5.2589166043853295\nCough\tAneurysm, False\t5\t6.573645755481662\nCough\tAneurysm, Ruptured\t2\t2.6294583021926647\nCough\tAortic Rupture\t3\t3.944187453288997\nCough\tAortic Aneurysm\t3\t3.944187453288997\nCough\tAortic Aneurysm, Thoracic\t9\t11.83256235986699\nCough\tAngioedema\t9\t11.83256235986699\nCough\tAortic Diseases\t1\t1.3147291510963324\nCough\tAortitis\t2\t2.6294583021926647\nCough\tArterial Occlusive Diseases\t4\t5.2589166043853295\nCough\tArteriosclerosis\t1\t1.3147291510963324\nCough\tArteritis\t2\t2.6294583021926647\nCough\tDiabetic Angiopathies\t1\t1.3147291510963324\nCough\tDiabetic Foot\t1\t1.3147291510963324\nCough\tEmbolism\t3\t3.944187453288997\nCough\tEmbolism, Air\t13\t17.09147896425232\nCough\tEmbolism, Fat\t1\t1.3147291510963324\nCough\tEmbolism, Paradoxical\t2\t2.6294583021926647\nCough\tVenous Thromboembolism\t1\t1.3147291510963324\nCough\tThrombosis\t3\t3.944187453288997\nCough\tVenous Thrombosis\t1\t1.3147291510963324\nCough\tThrombophlebitis\t3\t3.944187453288997\nCough\tEhlers-Danlos Syndrome\t2\t2.6294583021926647\nCough\tHypertension\t93\t122.26981105195891\nCough\tHypotension\t7\t9.203104057674327\nCough\tSuperior Vena Cava Syndrome\t4\t5.2589166043853295\nCough\tVaricose Veins\t3\t3.944187453288997\nCough\tVasculitis\t3\t3.944187453288997\nCough\tMucocutaneous Lymph Node Syndrome\t7\t9.203104057674327\nCough\tPurpura, Schoenlein-Henoch\t1\t1.3147291510963324\nCough\tChurg-Strauss Syndrome\t3\t3.944187453288997\nCough\tVasculitis, Leukocytoclastic, Cutaneous\t2\t2.6294583021926647\nCough\tVenous Insufficiency\t2\t2.6294583021926647\nCough\tHematologic Diseases\t1\t1.3147291510963324\nCough\tAnemia\t5\t6.573645755481662\nCough\tAnemia, Aplastic\t1\t1.3147291510963324\nCough\tAnemia, Sickle Cell\t13\t17.09147896425232\nCough\tSickle Cell Trait\t1\t1.3147291510963324\nCough\tbeta-Thalassemia\t2\t2.6294583021926647\nCough\tAnemia, Pernicious\t1\t1.3147291510963324\nCough\tAnemia, Refractory\t1\t1.3147291510963324\nCough\tBlood Coagulation Disorders\t1\t1.3147291510963324\nCough\tHemophilia A\t1\t1.3147291510963324\nCough\tWiskott-Aldrich Syndrome\t1\t1.3147291510963324\nCough\tEcchymosis\t2\t2.6294583021926647\nCough\tPurpura\t3\t3.944187453288997\nCough\tThrombocytopenia\t1\t1.3147291510963324\nCough\tAgammaglobulinemia\t2\t2.6294583021926647\nCough\tIgG Deficiency\t1\t1.3147291510963324\nCough\tMyelodysplastic Syndromes\t1\t1.3147291510963324\nCough\tPolycythemia Vera\t3\t3.944187453288997\nCough\tEosinophilia\t48\t63.10699925262395\nCough\tAngiolymphoid Hyperplasia with Eosinophilia\t2\t2.6294583021926647\nCough\tHypereosinophilic Syndrome\t6\t7.888374906577994\nCough\tLeukocytosis\t3\t3.944187453288997\nCough\tLymphocytosis\t2\t2.6294583021926647\nCough\tChediak-Higashi Syndrome\t1\t1.3147291510963324\nCough\tGranulomatous Disease, Chronic\t2\t2.6294583021926647\nCough\tJobs Syndrome              0.0000000000
    ## Mandibular Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Tuberculosis
    ## Lupus Nephritis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        0.039688980
    ## Uterine Cervical Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              0.002267452
    ## Tuberculosis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           1.000000000
    ## Silo Fillers Disease\t1\t1.3147291510963324\nCough\tAnti-Glomerular Basement Membrane Disease\t3\t3.944187453288997\nCough\tHistiocytosis, Langerhans-Cell\t10\t13.147291510963324\nCough\tIdiopathic Pulmonary Fibrosis\t29\t38.12714538179364\nCough\tPneumoconiosis\t19\t24.979853870830315\nCough\tAsbestosis\t9\t11.83256235986699\nCough\tByssinosis\t4\t5.2589166043853295\nCough\tSilicosis\t8\t10.517833208770659\nCough\tSarcoidosis, Pulmonary\t20\t26.29458302192665\nCough\tWegener Granulomatosis\t9\t11.83256235986699\nCough\tLung Diseases, Obstructive\t93\t122.26981105195891\nCough\tPulmonary Disease, Chronic Obstructive\t90\t118.3256235986699\nCough\tLung Injury\t1\t1.3147291510963324\nCough\tMeconium Aspiration Syndrome\t1\t1.3147291510963324\nCough\tBronchopulmonary Dysplasia\t2\t2.6294583021926647\nCough\tPneumonia\t95\t124.89926935415157\nCough\tPleuropneumonia\t1\t1.3147291510963324\nCough\tPneumonia, Aspiration\t35\t46.01552028837163\nCough\tPneumonia, Lipid\t5\t6.573645755481662\nCough\tPulmonary Alveolar Proteinosis\t7\t9.203104057674327\nCough\tPulmonary Atelectasis\t20\t26.29458302192665\nCough\tMiddle Lobe Syndrome\t5\t6.573645755481662\nCough\tPulmonary Edema\t21\t27.60931217302298\nCough\tPulmonary Embolism\t22\t28.92404132411931\nCough\tPulmonary Emphysema\t31\t40.756603683986306\nCough\tLung, Hyperlucent\t1\t1.3147291510963324\nCough\tPulmonary Eosinophilia\t30\t39.44187453288997\nCough\tPulmonary Fibrosis\t27\t35.49768707960097\nCough\tPulmonary Veno-Occlusive Disease\t1\t1.3147291510963324\nCough\tRespiratory Distress Syndrome, Adult\t8\t10.517833208770659\nCough\tRespiratory Distress Syndrome, Newborn\t6\t7.888374906577994\nCough\tScimitar Syndrome\t2\t2.6294583021926647\nCough\tNose Diseases\t6\t7.888374906577994\nCough\tEpistaxis\t2\t2.6294583021926647\nCough\tNasal Obstruction\t4\t5.2589166043853295\nCough\tNasal Polyps\t1\t1.3147291510963324\nCough\tParanasal Sinus Diseases\t3\t3.944187453288997\nCough\tSinusitis\t46\t60.47754095043129\nCough\tMaxillary Sinusitis\t2\t2.6294583021926647\nCough\tRhinitis\t54\t70.99537415920194\nCough\tRhinitis, Allergic, Perennial\t18\t23.66512471973398\nCough\tRhinitis, Allergic, Seasonal\t24\t31.553499626311975\nCough\tRhinitis, Atrophic\t1\t1.3147291510963324\nCough\tRhinitis, Vasomotor\t1\t1.3147291510963324\nCough\tPleural Diseases\t11\t14.462020662059656\nCough\tChylothorax\t1\t1.3147291510963324\nCough\tHydrothorax\t2\t2.6294583021926647\nCough\tPleural Effusion\t21\t27.60931217302298\nCough\tPleurisy\t9\t11.83256235986699\nCough\tPneumothorax\t23\t30.238770475215645\nCough\tRespiration Disorders\t72\t94.66049887893593\nCough\tAltitude Sickness\t5\t6.573645755481662\nCough\tApnea\t9\t11.83256235986699\nCough\tSleep Apnea Syndromes\t13\t17.09147896425232\nCough\tSleep Apnea, Central\t1\t1.3147291510963324\nCough\tSleep Apnea, Obstructive\t5\t6.573645755481662\nCough\tCough\t4598\t6045.124636740937\nCough\tDyspnea\t155\t203.78301841993152\nCough\tDyspnea, Paroxysmal\t2\t2.6294583021926647\nCough\tHyperventilation\t10\t13.147291510963324\nCough\tMouth Breathing\t2\t2.6294583021926647\nCough\tRespiratory Aspiration\t13\t17.09147896425232\nCough\tRespiratory Insufficiency\t60\t78.88374906577994\nCough\tAirway Obstruction\t70\t92.03104057674327\nCough\tHypoventilation\t2\t2.6294583021926647\nCough\tRespiratory Paralysis\t4\t5.2589166043853295\nCough\tRespiratory Hypersensitivity\t52\t68.36591585700928\nCough\tRespiratory System Abnormalities\t1\t1.3147291510963324\nCough\tBronchopulmonary Sequestration\t4\t5.2589166043853295\nCough\tRespiratory Tract Fistula\t3\t3.944187453288997\nCough\tEpiglottitis\t4\t5.2589166043853295\nCough\tTracheitis\t10\t13.147291510963324\nCough\tThoracic Diseases\t7\t9.203104057674327\nCough\tMediastinal Diseases\t8\t10.517833208770659\nCough\tMediastinal Emphysema\t20\t26.29458302192665\nCough\tMediastinitis\t1\t1.3147291510963324\nCough\tTracheal Diseases\t52\t68.36591585700928\nCough\tTracheal Stenosis\t14\t18.406208115348655\nCough\tEar Diseases\t1\t1.3147291510963324\nCough\tEarache\t2\t2.6294583021926647\nCough\tHearing Loss, Bilateral\t1\t1.3147291510963324\nCough\tHearing Loss, Functional\t1\t1.3147291510963324\nCough\tLabyrinth Diseases\t1\t1.3147291510963324\nCough\tVertigo\t1\t1.3147291510963324\nCough\tOtitis\t1\t1.3147291510963324\nCough\tOtitis Externa\t1\t1.3147291510963324\nCough\tOtitis Media\t5\t6.573645755481662\nCough\tOtitis Media with Effusion\t1\t1.3147291510963324\nCough\tMultiple Sclerosis\t6\t7.888374906577994\nCough\tMyasthenia Gravis\t1\t1.3147291510963324\nCough\tGuillain-Barre Syndrome\t2\t2.6294583021926647\nCough\tHereditary Sensory and Autonomic Neuropathies\t3\t3.944187453288997\nCough\tGiant Cell Arteritis\t26\t34.18295792850464\nCough\tAutonomic Nervous System Diseases\t4\t5.2589166043853295\nCough\tAdie Syndrome\t4\t5.2589166043853295\nCough\tHypotension, Orthostatic\t1\t1.3147291510963324\nCough\tSyncope, Vasovagal\t2\t2.6294583021926647\nCough\tCentral Nervous System Diseases\t1\t1.3147291510963324\nCough\tBrain Diseases\t3\t3.944187453288997\nCough\tParkinson Disease\t11\t14.462020662059656\nCough\tParkinson Disease, Postencephalitic\t1\t1.3147291510963324\nCough\tSupranuclear Palsy, Progressive\t1\t1.3147291510963324\nCough\tTourette Syndrome\t4\t5.2589166043853295\nCough\tCerebral Palsy\t4\t5.2589166043853295\nCough\tBrain Death\t1\t1.3147291510963324\nCough\tBrain Diseases, Metabolic, Inborn\t1\t1.3147291510963324\nCough\tGlycogen Storage Disease Type II\t2\t2.6294583021926647\nCough\tNiemann-Pick Disease, Type B\t1\t1.3147291510963324\nCough\tBrain Edema\t1\t1.3147291510963324\nCough\tBrain Injuries\t2\t2.6294583021926647\nCough\tPneumocephalus\t3\t3.944187453288997\nCough\tCerebellar Diseases\t1\t1.3147291510963324\nCough\tCerebellar Ataxia\t1\t1.3147291510963324\nCough\tAtaxia Telangiectasia\t1\t1.3147291510963324\nCough\tCerebrovascular Disorders\t7\t9.203104057674327\nCough\tBrain Ischemia\t3\t3.944187453288997\nCough\tBrain Infarction\t1\t1.3147291510963324\nCough\tBrain Stem Infarctions\t1\t1.3147291510963324\nCough\tLateral Medullary Syndrome\t1\t1.3147291510963324\nCough\tCerebral Infarction\t18\t23.66512471973398\nCough\tInfarction, Middle Cerebral Artery\t1\t1.3147291510963324\nCough\tIschemic Attack, Transient\t1\t1.3147291510963324\nCough\tCarotid Artery Diseases\t4\t5.2589166043853295\nCough\tCarotid Artery Thrombosis\t1\t1.3147291510963324\nCough\tCarotid Stenosis\t1\t1.3147291510963324\nCough\tVertebral Artery Dissection\t1\t1.3147291510963324\nCough\tIntracranial Aneurysm\t2\t2.6294583021926647\nCough\tIntracranial Arteriosclerosis\t1\t1.3147291510963324\nCough\tIntracranial Arteriovenous Malformations\t1\t1.3147291510963324\nCough\tIntracranial Embolism and Thrombosis\t2\t2.6294583021926647\nCough\tIntracranial Embolism\t3\t3.944187453288997\nCough\tCerebral Hemorrhage\t4\t5.2589166043853295\nCough\tHematoma, Epidural, Cranial\t2\t2.6294583021926647\nCough\tHematoma, Subdural\t2\t2.6294583021926647\nCough\tSubarachnoid Hemorrhage\t2\t2.6294583021926647\nCough\tStroke\t15\t19.720937266444984\nCough\tVascular Headaches\t1\t1.3147291510963324\nCough\tDementia\t1\t1.3147291510963324\nCough\tCreutzfeldt-Jakob Syndrome\t2\t2.6294583021926647\nCough\tMeningoencephalitis\t2\t2.6294583021926647\nCough\tEpilepsy\t11\t14.462020662059656\nCough\tEpilepsies, Partial\t3\t3.944187453288997\nCough\tEpilepsy, Temporal Lobe\t3\t3.944187453288997\nCough\tSeizures\t10\t13.147291510963324\nCough\tHeadache Disorders\t1\t1.3147291510963324\nCough\tHeadache Disorders, Primary\t2\t2.6294583021926647\nCough\tMigraine Disorders\t4\t5.2589166043853295\nCough\tMigraine without Aura\t1\t1.3147291510963324\nCough\tTension-Type Headache\t1\t1.3147291510963324\nCough\tCluster Headache\t2\t2.6294583021926647\nCough\tParoxysmal Hemicrania\t1\t1.3147291510963324\nCough\tHydrocephalus\t4\t5.2589166043853295\nCough\tHypoxia, Brain\t2\t2.6294583021926647\nCough\tIntracranial Hypertension\t1\t1.3147291510963324\nCough\tHypertensive Encephalopathy\t1\t1.3147291510963324\nCough\tPseudotumor Cerebri\t2\t2.6294583021926647\nCough\tIntracranial Hypotension\t2\t2.6294583021926647\nCough\tSubdural Effusion\t1\t1.3147291510963324\nCough\tMovement Disorders\t2\t2.6294583021926647\nCough\tDyskinesias\t1\t1.3147291510963324\nCough\tTorticollis\t2\t2.6294583021926647\nCough\tEssential Tremor\t1\t1.3147291510963324\nCough\tTic Disorders\t8\t10.517833208770659\nCough\tSpinal Cord Diseases\t2\t2.6294583021926647\nCough\tAmyotrophic Lateral Sclerosis\t18\t23.66512471973398\nCough\tMuscular Atrophy, Spinal\t1\t1.3147291510963324\nCough\tSpinal Muscular Atrophies of Childhood\t3\t3.944187453288997\nCough\tSpinal Cord Injuries\t18\t23.66512471973398\nCough\tSyringomyelia\t5\t6.573645755481662\nCough\tCranial Nerve Diseases\t2\t2.6294583021926647\nCough\tHypoglossal Nerve Diseases\t1\t1.3147291510963324\nCough\tNystagmus, Pathologic\t2\t2.6294583021926647\nCough\tOptic Nerve Diseases\t2\t2.6294583021926647\nCough\tOptic Neuritis\t1\t1.3147291510963324\nCough\tTrigeminal Neuralgia\t1\t1.3147291510963324\nCough\tVagus Nerve Diseases\t6\t7.888374906577994\nCough\tHereditary Sensory and Motor Neuropathy\t3\t3.944187453288997\nCough\tArnold-Chiari Malformation\t14\t18.406208115348655\nCough\tMeningocele\t1\t1.3147291510963324\nCough\tMotor Neuron Disease\t3\t3.944187453288997\nCough\tBulbar Palsy, Progressive\t2\t2.6294583021926647\nCough\tDecerebrate State\t8\t10.517833208770659\nCough\tDystonia\t1\t1.3147291510963324\nCough\tMyoclonus\t1\t1.3147291510963324\nCough\tPsychomotor Agitation\t1\t1.3147291510963324\nCough\tTics\t1\t1.3147291510963324\nCough\tLanguage Disorders\t1\t1.3147291510963324\nCough\tSpeech Disorders\t1\t1.3147291510963324\nCough\tMutism\t1\t1.3147291510963324\nCough\tConfusion\t2\t2.6294583021926647\nCough\tDelirium\t1\t1.3147291510963324\nCough\tConsciousness Disorders\t6\t7.888374906577994\nCough\tUnconsciousness\t2\t2.6294583021926647\nCough\tComa\t3\t3.944187453288997\nCough\tSyncope\t110\t144.62020662059655\nCough\tMemory Disorders\t1\t1.3147291510963324\nCough\tAmnesia\t1\t1.3147291510963324\nCough\tMental Retardation\t1\t1.3147291510963324\nCough\tDown Syndrome\t3\t3.944187453288997\nCough\tHallucinations\t2\t2.6294583021926647\nCough\tNeurogenic Inflammation\t1\t1.3147291510963324\nCough\tMuscular Atrophy\t1\t1.3147291510963324\nCough\tSpasm\t1\t1.3147291510963324\nCough\tPain\t30\t39.44187453288997\nCough\tBack Pain\t4\t5.2589166043853295\nCough\tHeadache\t43\t56.53335349714229\nCough\tNeck Pain\t1\t1.3147291510963324\nCough\tSciatica\t1\t1.3147291510963324\nCough\tParalysis\t2\t2.6294583021926647\nCough\tHemiplegia\t2\t2.6294583021926647\nCough\tParaplegia\t4\t5.2589166043853295\nCough\tQuadriplegia\t14\t18.406208115348655\nCough\tTonic Pupil\t2\t2.6294583021926647\nCough\tSensation Disorders\t1\t1.3147291510963324\nCough\tDizziness\t3\t3.944187453288997\nCough\tOlfaction Disorders\t1\t1.3147291510963324\nCough\tParesthesia\t1\t1.3147291510963324\nCough\tDysgeusia\t1\t1.3147291510963324\nCough\tVision Disorders\t1\t1.3147291510963324\nCough\tBlindness\t4\t5.2589166043853295\nCough\tNeuromuscular Diseases\t36\t47.33024943946796\nCough\tPeripheral Nervous System Diseases\t4\t5.2589166043853295\nCough\tDiabetic Neuropathies\t7\t9.203104057674327\nCough\tMononeuropathies\t1\t1.3147291510963324\nCough\tNerve Compression Syndromes\t4\t5.2589166043853295\nCough\tThoracic Outlet Syndrome\t1\t1.3147291510963324\nCough\tNeuritis\t1\t1.3147291510963324\nCough\tPOEMS Syndrome\t1\t1.3147291510963324\nCough\tNeurotoxicity Syndromes\t1\t1.3147291510963324\nCough\tArsenic Poisoning\t2\t2.6294583021926647\nCough\tSleep Disorders\t7\t9.203104057674327\nCough\tSleep Initiation and Maintenance Disorders\t4\t5.2589166043853295\nCough\tCraniocerebral Trauma\t4\t5.2589166043853295\nCough\tShaken Baby Syndrome\t1\t1.3147291510963324\nCough\tSkull Fractures\t1\t1.3147291510963324\nCough\tConjunctival Diseases\t1\t1.3147291510963324\nCough\tConjunctivitis\t4\t5.2589166043853295\nCough\tConjunctivitis, Allergic\t1\t1.3147291510963324\nCough\tKeratitis\t1\t1.3147291510963324\nCough\tChoroid Hemorrhage\t1\t1.3147291510963324\nCough\tRetinal Hemorrhage\t3\t3.944187453288997\nCough\tEyelid Diseases\t1\t1.3147291510963324\nCough\tBlepharoptosis\t1\t1.3147291510963324\nCough\tLacrimal Apparatus Diseases\t2\t2.6294583021926647\nCough\tGlaucoma\t3\t3.944187453288997\nCough\tGlaucoma, Open-Angle\t1\t1.3147291510963324\nCough\tOcular Hypotension\t1\t1.3147291510963324\nCough\tOrbital Diseases\t3\t3.944187453288997\nCough\tExophthalmos\t2\t2.6294583021926647\nCough\tMyopia\t1\t1.3147291510963324\nCough\tDiabetic Retinopathy\t1\t1.3147291510963324\nCough\tIris Diseases\t1\t1.3147291510963324\nCough\tGenital Diseases, Male\t1\t1.3147291510963324\nCough\tHemospermia\t1\t1.3147291510963324\nCough\tProstatic Hyperplasia\t2\t2.6294583021926647\nCough\tUrologic Diseases\t1\t1.3147291510963324\nCough\tKidney Diseases\t2\t2.6294583021926647\nCough\tDiabetes Insipidus\t1\t1.3147291510963324\nCough\tDiabetes Insipidus, Neurogenic\t1\t1.3147291510963324\nCough\tDiabetic Nephropathies\t1\t1.3147291510963324\nCough\tGlomerulonephritis\t2\t2.6294583021926647\nCough\tGlomerulonephritis, Membranoproliferative\t1\t1.3147291510963324\nCough\tNephrotic Syndrome\t2\t2.6294583021926647\nCough\tRenal Artery Obstruction\t1\t1.3147291510963324\nCough\tRenal Insufficiency\t1\t1.3147291510963324\nCough\tAcute Kidney Injury\t4\t5.2589166043853295\nCough\tKidney Failure, Chronic\t6\t7.888374906577994\nCough\tUrethral Diseases\t1\t1.3147291510963324\nCough\tUrinary Bladder Neck Obstruction\t1\t1.3147291510963324\nCough\tUrinary Bladder, Overactive\t2\t2.6294583021926647\nCough\tUrination Disorders\t6\t7.888374906577994\nCough\tHematuria\t1\t1.3147291510963324\nCough\tOliguria\t1\t1.3147291510963324\nCough\tAlbuminuria\t2\t2.6294583021926647\nCough\tUrinary Incontinence\t28\t36.81241623069731\nCough\tUrinary Incontinence, Stress\t99\t130.1581859585369\nCough\tUrinary Incontinence, Urge\t1\t1.3147291510963324\nCough\tFemale Urogenital Diseases\t1\t1.3147291510963324\nCough\tFallopian Tube Diseases\t1\t1.3147291510963324\nCough\tAnovulation\t1\t1.3147291510963324\nCough\tOvarian Hyperstimulation Syndrome\t1\t1.3147291510963324\nCough\tEndometriosis\t4\t5.2589166043853295\nCough\tInfertility, Female\t1\t1.3147291510963324\nCough\tUterine Cervical Incompetence\t1\t1.3147291510963324\nCough\tUterine Prolapse\t4\t5.2589166043853295\nCough\tVaginal Diseases\t2\t2.6294583021926647\nCough\tPregnancy Complications\t5\t6.573645755481662\nCough\tAbruptio Placentae\t1\t1.3147291510963324\nCough\tFetal Membranes, Premature Rupture\t1\t1.3147291510963324\nCough\tPregnancy Complications, Cardiovascular\t1\t1.3147291510963324\nCough\tPregnancy in Diabetics\t1\t1.3147291510963324\nCough\tPuerperal Disorders\t3\t3.944187453288997\nCough\tCardiovascular Abnormalities\t2\t2.6294583021926647\nCough\tHeart Defects, Congenital\t1\t1.3147291510963324\nCough\tCoronary Vessel Anomalies\t1\t1.3147291510963324\nCough\tHeart Septal Defects\t1\t1.3147291510963324\nCough\tHeart Septal Defects, Atrial\t11\t14.462020662059656\nCough\tHeart Septal Defects, Ventricular\t1\t1.3147291510963324\nCough\tTetralogy of Fallot\t1\t1.3147291510963324\nCough\tTransposition of Great Vessels\t1\t1.3147291510963324\nCough\tVascular Malformations\t1\t1.3147291510963324\nCough\tArteriovenous Malformations\t2\t2.6294583021926647\nCough\tVascular Fistula\t1\t1.3147291510963324\nCough\tArterio-Arterial Fistula\t1\t1.3147291510963324\nCough\tHeart Diseases\t11\t14.462020662059656\nCough\tArrhythmias, Cardiac\t15\t19.720937266444984\nCough\tSick Sinus Syndrome\t1\t1.3147291510963324\nCough\tAtrial Fibrillation\t3\t3.944187453288997\nCough\tBradycardia\t1\t1.3147291510963324\nCough\tAtrial Premature Complexes\t3\t3.944187453288997\nCough\tVentricular Premature Complexes\t4\t5.2589166043853295\nCough\tHeart Block\t8\t10.517833208770659\nCough\tAtrioventricular Block\t3\t3.944187453288997\nCough\tLong QT Syndrome\t2\t2.6294583021926647\nCough\tTachycardia\t8\t10.517833208770659\nCough\tTachycardia, Paroxysmal\t1\t1.3147291510963324\nCough\tTachycardia, Supraventricular\t2\t2.6294583021926647\nCough\tTachycardia, Ectopic Atrial\t1\t1.3147291510963324\nCough\tTachycardia, Ventricular\t2\t2.6294583021926647\nCough\tTorsades de Pointes\t1\t1.3147291510963324\nCough\tVentricular Fibrillation\t11\t14.462020662059656\nCough\tCardiac Output, Low\t3\t3.944187453288997\nCough\tCardiac Tamponade\t1\t1.3147291510963324\nCough\tCardiomegaly\t1\t1.3147291510963324\nCough\tHypertrophy, Left Ventricular\t2\t2.6294583021926647\nCough\tHypertrophy, Right Ventricular\t1\t1.3147291510963324\nCough\tCardiomyopathies\t4\t5.2589166043853295\nCough\tCardiomyopathy, Hypertrophic\t2\t2.6294583021926647\nCough\tCardiomyopathy, Restrictive\t1\t1.3147291510963324\nCough\tMyocardial Reperfusion Injury\t1\t1.3147291510963324\nCough\tMyocarditis\t4\t5.2589166043853295\nCough\tHeart Arrest\t11\t14.462020662059656\nCough\tHeart Failure\t31\t40.756603683986306\nCough\tAortic Valve Insufficiency\t2\t2.6294583021926647\nCough\tMitral Valve Prolapse\t1\t1.3147291510963324\nCough\tMitral Valve Insufficiency\t1\t1.3147291510963324\nCough\tMitral Valve Stenosis\t4\t5.2589166043853295\nCough\tTricuspid Valve Stenosis\t1\t1.3147291510963324\nCough\tMyocardial Ischemia\t2\t2.6294583021926647\nCough\tAngina Pectoris\t2\t2.6294583021926647\nCough\tAngina, Unstable\t1\t1.3147291510963324\nCough\tCoronary Disease\t7\t9.203104057674327\nCough\tCoronary Artery Disease\t7\t9.203104057674327\nCough\tMyocardial Infarction\t13\t17.09147896425232\nCough\tShock, Cardiogenic\t2\t2.6294583021926647\nCough\tPericardial Effusion\t3\t3.944187453288997\nCough\tPericarditis\t6\t7.888374906577994\nCough\tPericarditis, Constrictive\t3\t3.944187453288997\nCough\tPneumopericardium\t3\t3.944187453288997\nCough\tPulmonary Heart Disease\t6\t7.888374906577994\nCough\tVentricular Dysfunction, Left\t5\t6.573645755481662\nCough\tTakotsubo Cardiomyopathy\t1\t1.3147291510963324\nCough\tVentricular Outflow Obstruction\t1\t1.3147291510963324\nCough\tVascular Diseases\t2\t2.6294583021926647\nCough\tAneurysm\t5\t6.573645755481662\nCough\tAneurysm, Dissecting\t4\t5.2589166043853295\nCough\tAneurysm, False\t5\t6.573645755481662\nCough\tAneurysm, Ruptured\t2\t2.6294583021926647\nCough\tAortic Rupture\t3\t3.944187453288997\nCough\tAortic Aneurysm\t3\t3.944187453288997\nCough\tAortic Aneurysm, Thoracic\t9\t11.83256235986699\nCough\tAngioedema\t9\t11.83256235986699\nCough\tAortic Diseases\t1\t1.3147291510963324\nCough\tAortitis\t2\t2.6294583021926647\nCough\tArterial Occlusive Diseases\t4\t5.2589166043853295\nCough\tArteriosclerosis\t1\t1.3147291510963324\nCough\tArteritis\t2\t2.6294583021926647\nCough\tDiabetic Angiopathies\t1\t1.3147291510963324\nCough\tDiabetic Foot\t1\t1.3147291510963324\nCough\tEmbolism\t3\t3.944187453288997\nCough\tEmbolism, Air\t13\t17.09147896425232\nCough\tEmbolism, Fat\t1\t1.3147291510963324\nCough\tEmbolism, Paradoxical\t2\t2.6294583021926647\nCough\tVenous Thromboembolism\t1\t1.3147291510963324\nCough\tThrombosis\t3\t3.944187453288997\nCough\tVenous Thrombosis\t1\t1.3147291510963324\nCough\tThrombophlebitis\t3\t3.944187453288997\nCough\tEhlers-Danlos Syndrome\t2\t2.6294583021926647\nCough\tHypertension\t93\t122.26981105195891\nCough\tHypotension\t7\t9.203104057674327\nCough\tSuperior Vena Cava Syndrome\t4\t5.2589166043853295\nCough\tVaricose Veins\t3\t3.944187453288997\nCough\tVasculitis\t3\t3.944187453288997\nCough\tMucocutaneous Lymph Node Syndrome\t7\t9.203104057674327\nCough\tPurpura, Schoenlein-Henoch\t1\t1.3147291510963324\nCough\tChurg-Strauss Syndrome\t3\t3.944187453288997\nCough\tVasculitis, Leukocytoclastic, Cutaneous\t2\t2.6294583021926647\nCough\tVenous Insufficiency\t2\t2.6294583021926647\nCough\tHematologic Diseases\t1\t1.3147291510963324\nCough\tAnemia\t5\t6.573645755481662\nCough\tAnemia, Aplastic\t1\t1.3147291510963324\nCough\tAnemia, Sickle Cell\t13\t17.09147896425232\nCough\tSickle Cell Trait\t1\t1.3147291510963324\nCough\tbeta-Thalassemia\t2\t2.6294583021926647\nCough\tAnemia, Pernicious\t1\t1.3147291510963324\nCough\tAnemia, Refractory\t1\t1.3147291510963324\nCough\tBlood Coagulation Disorders\t1\t1.3147291510963324\nCough\tHemophilia A\t1\t1.3147291510963324\nCough\tWiskott-Aldrich Syndrome\t1\t1.3147291510963324\nCough\tEcchymosis\t2\t2.6294583021926647\nCough\tPurpura\t3\t3.944187453288997\nCough\tThrombocytopenia\t1\t1.3147291510963324\nCough\tAgammaglobulinemia\t2\t2.6294583021926647\nCough\tIgG Deficiency\t1\t1.3147291510963324\nCough\tMyelodysplastic Syndromes\t1\t1.3147291510963324\nCough\tPolycythemia Vera\t3\t3.944187453288997\nCough\tEosinophilia\t48\t63.10699925262395\nCough\tAngiolymphoid Hyperplasia with Eosinophilia\t2\t2.6294583021926647\nCough\tHypereosinophilic Syndrome\t6\t7.888374906577994\nCough\tLeukocytosis\t3\t3.944187453288997\nCough\tLymphocytosis\t2\t2.6294583021926647\nCough\tChediak-Higashi Syndrome\t1\t1.3147291510963324\nCough\tGranulomatous Disease, Chronic\t2\t2.6294583021926647\nCough\tJobs Syndrome  0.342110379
    ## Mandibular Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    0.010256138
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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Silo Fillers Disease\t1\t1.3147291510963324\nCough\tAnti-Glomerular Basement Membrane Disease\t3\t3.944187453288997\nCough\tHistiocytosis, Langerhans-Cell\t10\t13.147291510963324\nCough\tIdiopathic Pulmonary Fibrosis\t29\t38.12714538179364\nCough\tPneumoconiosis\t19\t24.979853870830315\nCough\tAsbestosis\t9\t11.83256235986699\nCough\tByssinosis\t4\t5.2589166043853295\nCough\tSilicosis\t8\t10.517833208770659\nCough\tSarcoidosis, Pulmonary\t20\t26.29458302192665\nCough\tWegener Granulomatosis\t9\t11.83256235986699\nCough\tLung Diseases, Obstructive\t93\t122.26981105195891\nCough\tPulmonary Disease, Chronic Obstructive\t90\t118.3256235986699\nCough\tLung Injury\t1\t1.3147291510963324\nCough\tMeconium Aspiration Syndrome\t1\t1.3147291510963324\nCough\tBronchopulmonary Dysplasia\t2\t2.6294583021926647\nCough\tPneumonia\t95\t124.89926935415157\nCough\tPleuropneumonia\t1\t1.3147291510963324\nCough\tPneumonia, Aspiration\t35\t46.01552028837163\nCough\tPneumonia, Lipid\t5\t6.573645755481662\nCough\tPulmonary Alveolar Proteinosis\t7\t9.203104057674327\nCough\tPulmonary Atelectasis\t20\t26.29458302192665\nCough\tMiddle Lobe Syndrome\t5\t6.573645755481662\nCough\tPulmonary Edema\t21\t27.60931217302298\nCough\tPulmonary Embolism\t22\t28.92404132411931\nCough\tPulmonary Emphysema\t31\t40.756603683986306\nCough\tLung, Hyperlucent\t1\t1.3147291510963324\nCough\tPulmonary Eosinophilia\t30\t39.44187453288997\nCough\tPulmonary Fibrosis\t27\t35.49768707960097\nCough\tPulmonary Veno-Occlusive Disease\t1\t1.3147291510963324\nCough\tRespiratory Distress Syndrome, Adult\t8\t10.517833208770659\nCough\tRespiratory Distress Syndrome, Newborn\t6\t7.888374906577994\nCough\tScimitar Syndrome\t2\t2.6294583021926647\nCough\tNose Diseases\t6\t7.888374906577994\nCough\tEpistaxis\t2\t2.6294583021926647\nCough\tNasal Obstruction\t4\t5.2589166043853295\nCough\tNasal Polyps\t1\t1.3147291510963324\nCough\tParanasal Sinus Diseases\t3\t3.944187453288997\nCough\tSinusitis\t46\t60.47754095043129\nCough\tMaxillary Sinusitis\t2\t2.6294583021926647\nCough\tRhinitis\t54\t70.99537415920194\nCough\tRhinitis, Allergic, Perennial\t18\t23.66512471973398\nCough\tRhinitis, Allergic, Seasonal\t24\t31.553499626311975\nCough\tRhinitis, Atrophic\t1\t1.3147291510963324\nCough\tRhinitis, Vasomotor\t1\t1.3147291510963324\nCough\tPleural Diseases\t11\t14.462020662059656\nCough\tChylothorax\t1\t1.3147291510963324\nCough\tHydrothorax\t2\t2.6294583021926647\nCough\tPleural Effusion\t21\t27.60931217302298\nCough\tPleurisy\t9\t11.83256235986699\nCough\tPneumothorax\t23\t30.238770475215645\nCough\tRespiration Disorders\t72\t94.66049887893593\nCough\tAltitude Sickness\t5\t6.573645755481662\nCough\tApnea\t9\t11.83256235986699\nCough\tSleep Apnea Syndromes\t13\t17.09147896425232\nCough\tSleep Apnea, Central\t1\t1.3147291510963324\nCough\tSleep Apnea, Obstructive\t5\t6.573645755481662\nCough\tCough\t4598\t6045.124636740937\nCough\tDyspnea\t155\t203.78301841993152\nCough\tDyspnea, Paroxysmal\t2\t2.6294583021926647\nCough\tHyperventilation\t10\t13.147291510963324\nCough\tMouth Breathing\t2\t2.6294583021926647\nCough\tRespiratory Aspiration\t13\t17.09147896425232\nCough\tRespiratory Insufficiency\t60\t78.88374906577994\nCough\tAirway Obstruction\t70\t92.03104057674327\nCough\tHypoventilation\t2\t2.6294583021926647\nCough\tRespiratory Paralysis\t4\t5.2589166043853295\nCough\tRespiratory Hypersensitivity\t52\t68.36591585700928\nCough\tRespiratory System Abnormalities\t1\t1.3147291510963324\nCough\tBronchopulmonary Sequestration\t4\t5.2589166043853295\nCough\tRespiratory Tract Fistula\t3\t3.944187453288997\nCough\tEpiglottitis\t4\t5.2589166043853295\nCough\tTracheitis\t10\t13.147291510963324\nCough\tThoracic Diseases\t7\t9.203104057674327\nCough\tMediastinal Diseases\t8\t10.517833208770659\nCough\tMediastinal Emphysema\t20\t26.29458302192665\nCough\tMediastinitis\t1\t1.3147291510963324\nCough\tTracheal Diseases\t52\t68.36591585700928\nCough\tTracheal Stenosis\t14\t18.406208115348655\nCough\tEar Diseases\t1\t1.3147291510963324\nCough\tEarache\t2\t2.6294583021926647\nCough\tHearing Loss, Bilateral\t1\t1.3147291510963324\nCough\tHearing Loss, Functional\t1\t1.3147291510963324\nCough\tLabyrinth Diseases\t1\t1.3147291510963324\nCough\tVertigo\t1\t1.3147291510963324\nCough\tOtitis\t1\t1.3147291510963324\nCough\tOtitis Externa\t1\t1.3147291510963324\nCough\tOtitis Media\t5\t6.573645755481662\nCough\tOtitis Media with Effusion\t1\t1.3147291510963324\nCough\tMultiple Sclerosis\t6\t7.888374906577994\nCough\tMyasthenia Gravis\t1\t1.3147291510963324\nCough\tGuillain-Barre Syndrome\t2\t2.6294583021926647\nCough\tHereditary Sensory and Autonomic Neuropathies\t3\t3.944187453288997\nCough\tGiant Cell Arteritis\t26\t34.18295792850464\nCough\tAutonomic Nervous System Diseases\t4\t5.2589166043853295\nCough\tAdie Syndrome\t4\t5.2589166043853295\nCough\tHypotension, Orthostatic\t1\t1.3147291510963324\nCough\tSyncope, Vasovagal\t2\t2.6294583021926647\nCough\tCentral Nervous System Diseases\t1\t1.3147291510963324\nCough\tBrain Diseases\t3\t3.944187453288997\nCough\tParkinson Disease\t11\t14.462020662059656\nCough\tParkinson Disease, Postencephalitic\t1\t1.3147291510963324\nCough\tSupranuclear Palsy, Progressive\t1\t1.3147291510963324\nCough\tTourette Syndrome\t4\t5.2589166043853295\nCough\tCerebral Palsy\t4\t5.2589166043853295\nCough\tBrain Death\t1\t1.3147291510963324\nCough\tBrain Diseases, Metabolic, Inborn\t1\t1.3147291510963324\nCough\tGlycogen Storage Disease Type II\t2\t2.6294583021926647\nCough\tNiemann-Pick Disease, Type B\t1\t1.3147291510963324\nCough\tBrain Edema\t1\t1.3147291510963324\nCough\tBrain Injuries\t2\t2.6294583021926647\nCough\tPneumocephalus\t3\t3.944187453288997\nCough\tCerebellar Diseases\t1\t1.3147291510963324\nCough\tCerebellar Ataxia\t1\t1.3147291510963324\nCough\tAtaxia Telangiectasia\t1\t1.3147291510963324\nCough\tCerebrovascular Disorders\t7\t9.203104057674327\nCough\tBrain Ischemia\t3\t3.944187453288997\nCough\tBrain Infarction\t1\t1.3147291510963324\nCough\tBrain Stem Infarctions\t1\t1.3147291510963324\nCough\tLateral Medullary Syndrome\t1\t1.3147291510963324\nCough\tCerebral Infarction\t18\t23.66512471973398\nCough\tInfarction, Middle Cerebral Artery\t1\t1.3147291510963324\nCough\tIschemic Attack, Transient\t1\t1.3147291510963324\nCough\tCarotid Artery Diseases\t4\t5.2589166043853295\nCough\tCarotid Artery Thrombosis\t1\t1.3147291510963324\nCough\tCarotid Stenosis\t1\t1.3147291510963324\nCough\tVertebral Artery Dissection\t1\t1.3147291510963324\nCough\tIntracranial Aneurysm\t2\t2.6294583021926647\nCough\tIntracranial Arteriosclerosis\t1\t1.3147291510963324\nCough\tIntracranial Arteriovenous Malformations\t1\t1.3147291510963324\nCough\tIntracranial Embolism and Thrombosis\t2\t2.6294583021926647\nCough\tIntracranial Embolism\t3\t3.944187453288997\nCough\tCerebral Hemorrhage\t4\t5.2589166043853295\nCough\tHematoma, Epidural, Cranial\t2\t2.6294583021926647\nCough\tHematoma, Subdural\t2\t2.6294583021926647\nCough\tSubarachnoid Hemorrhage\t2\t2.6294583021926647\nCough\tStroke\t15\t19.720937266444984\nCough\tVascular Headaches\t1\t1.3147291510963324\nCough\tDementia\t1\t1.3147291510963324\nCough\tCreutzfeldt-Jakob Syndrome\t2\t2.6294583021926647\nCough\tMeningoencephalitis\t2\t2.6294583021926647\nCough\tEpilepsy\t11\t14.462020662059656\nCough\tEpilepsies, Partial\t3\t3.944187453288997\nCough\tEpilepsy, Temporal Lobe\t3\t3.944187453288997\nCough\tSeizures\t10\t13.147291510963324\nCough\tHeadache Disorders\t1\t1.3147291510963324\nCough\tHeadache Disorders, Primary\t2\t2.6294583021926647\nCough\tMigraine Disorders\t4\t5.2589166043853295\nCough\tMigraine without Aura\t1\t1.3147291510963324\nCough\tTension-Type Headache\t1\t1.3147291510963324\nCough\tCluster Headache\t2\t2.6294583021926647\nCough\tParoxysmal Hemicrania\t1\t1.3147291510963324\nCough\tHydrocephalus\t4\t5.2589166043853295\nCough\tHypoxia, Brain\t2\t2.6294583021926647\nCough\tIntracranial Hypertension\t1\t1.3147291510963324\nCough\tHypertensive Encephalopathy\t1\t1.3147291510963324\nCough\tPseudotumor Cerebri\t2\t2.6294583021926647\nCough\tIntracranial Hypotension\t2\t2.6294583021926647\nCough\tSubdural Effusion\t1\t1.3147291510963324\nCough\tMovement Disorders\t2\t2.6294583021926647\nCough\tDyskinesias\t1\t1.3147291510963324\nCough\tTorticollis\t2\t2.6294583021926647\nCough\tEssential Tremor\t1\t1.3147291510963324\nCough\tTic Disorders\t8\t10.517833208770659\nCough\tSpinal Cord Diseases\t2\t2.6294583021926647\nCough\tAmyotrophic Lateral Sclerosis\t18\t23.66512471973398\nCough\tMuscular Atrophy, Spinal\t1\t1.3147291510963324\nCough\tSpinal Muscular Atrophies of Childhood\t3\t3.944187453288997\nCough\tSpinal Cord Injuries\t18\t23.66512471973398\nCough\tSyringomyelia\t5\t6.573645755481662\nCough\tCranial Nerve Diseases\t2\t2.6294583021926647\nCough\tHypoglossal Nerve Diseases\t1\t1.3147291510963324\nCough\tNystagmus, Pathologic\t2\t2.6294583021926647\nCough\tOptic Nerve Diseases\t2\t2.6294583021926647\nCough\tOptic Neuritis\t1\t1.3147291510963324\nCough\tTrigeminal Neuralgia\t1\t1.3147291510963324\nCough\tVagus Nerve Diseases\t6\t7.888374906577994\nCough\tHereditary Sensory and Motor Neuropathy\t3\t3.944187453288997\nCough\tArnold-Chiari Malformation\t14\t18.406208115348655\nCough\tMeningocele\t1\t1.3147291510963324\nCough\tMotor Neuron Disease\t3\t3.944187453288997\nCough\tBulbar Palsy, Progressive\t2\t2.6294583021926647\nCough\tDecerebrate State\t8\t10.517833208770659\nCough\tDystonia\t1\t1.3147291510963324\nCough\tMyoclonus\t1\t1.3147291510963324\nCough\tPsychomotor Agitation\t1\t1.3147291510963324\nCough\tTics\t1\t1.3147291510963324\nCough\tLanguage Disorders\t1\t1.3147291510963324\nCough\tSpeech Disorders\t1\t1.3147291510963324\nCough\tMutism\t1\t1.3147291510963324\nCough\tConfusion\t2\t2.6294583021926647\nCough\tDelirium\t1\t1.3147291510963324\nCough\tConsciousness Disorders\t6\t7.888374906577994\nCough\tUnconsciousness\t2\t2.6294583021926647\nCough\tComa\t3\t3.944187453288997\nCough\tSyncope\t110\t144.62020662059655\nCough\tMemory Disorders\t1\t1.3147291510963324\nCough\tAmnesia\t1\t1.3147291510963324\nCough\tMental Retardation\t1\t1.3147291510963324\nCough\tDown Syndrome\t3\t3.944187453288997\nCough\tHallucinations\t2\t2.6294583021926647\nCough\tNeurogenic Inflammation\t1\t1.3147291510963324\nCough\tMuscular Atrophy\t1\t1.3147291510963324\nCough\tSpasm\t1\t1.3147291510963324\nCough\tPain\t30\t39.44187453288997\nCough\tBack Pain\t4\t5.2589166043853295\nCough\tHeadache\t43\t56.53335349714229\nCough\tNeck Pain\t1\t1.3147291510963324\nCough\tSciatica\t1\t1.3147291510963324\nCough\tParalysis\t2\t2.6294583021926647\nCough\tHemiplegia\t2\t2.6294583021926647\nCough\tParaplegia\t4\t5.2589166043853295\nCough\tQuadriplegia\t14\t18.406208115348655\nCough\tTonic Pupil\t2\t2.6294583021926647\nCough\tSensation Disorders\t1\t1.3147291510963324\nCough\tDizziness\t3\t3.944187453288997\nCough\tOlfaction Disorders\t1\t1.3147291510963324\nCough\tParesthesia\t1\t1.3147291510963324\nCough\tDysgeusia\t1\t1.3147291510963324\nCough\tVision Disorders\t1\t1.3147291510963324\nCough\tBlindness\t4\t5.2589166043853295\nCough\tNeuromuscular Diseases\t36\t47.33024943946796\nCough\tPeripheral Nervous System Diseases\t4\t5.2589166043853295\nCough\tDiabetic Neuropathies\t7\t9.203104057674327\nCough\tMononeuropathies\t1\t1.3147291510963324\nCough\tNerve Compression Syndromes\t4\t5.2589166043853295\nCough\tThoracic Outlet Syndrome\t1\t1.3147291510963324\nCough\tNeuritis\t1\t1.3147291510963324\nCough\tPOEMS Syndrome\t1\t1.3147291510963324\nCough\tNeurotoxicity Syndromes\t1\t1.3147291510963324\nCough\tArsenic Poisoning\t2\t2.6294583021926647\nCough\tSleep Disorders\t7\t9.203104057674327\nCough\tSleep Initiation and Maintenance Disorders\t4\t5.2589166043853295\nCough\tCraniocerebral Trauma\t4\t5.2589166043853295\nCough\tShaken Baby Syndrome\t1\t1.3147291510963324\nCough\tSkull Fractures\t1\t1.3147291510963324\nCough\tConjunctival Diseases\t1\t1.3147291510963324\nCough\tConjunctivitis\t4\t5.2589166043853295\nCough\tConjunctivitis, Allergic\t1\t1.3147291510963324\nCough\tKeratitis\t1\t1.3147291510963324\nCough\tChoroid Hemorrhage\t1\t1.3147291510963324\nCough\tRetinal Hemorrhage\t3\t3.944187453288997\nCough\tEyelid Diseases\t1\t1.3147291510963324\nCough\tBlepharoptosis\t1\t1.3147291510963324\nCough\tLacrimal Apparatus Diseases\t2\t2.6294583021926647\nCough\tGlaucoma\t3\t3.944187453288997\nCough\tGlaucoma, Open-Angle\t1\t1.3147291510963324\nCough\tOcular Hypotension\t1\t1.3147291510963324\nCough\tOrbital Diseases\t3\t3.944187453288997\nCough\tExophthalmos\t2\t2.6294583021926647\nCough\tMyopia\t1\t1.3147291510963324\nCough\tDiabetic Retinopathy\t1\t1.3147291510963324\nCough\tIris Diseases\t1\t1.3147291510963324\nCough\tGenital Diseases, Male\t1\t1.3147291510963324\nCough\tHemospermia\t1\t1.3147291510963324\nCough\tProstatic Hyperplasia\t2\t2.6294583021926647\nCough\tUrologic Diseases\t1\t1.3147291510963324\nCough\tKidney Diseases\t2\t2.6294583021926647\nCough\tDiabetes Insipidus\t1\t1.3147291510963324\nCough\tDiabetes Insipidus, Neurogenic\t1\t1.3147291510963324\nCough\tDiabetic Nephropathies\t1\t1.3147291510963324\nCough\tGlomerulonephritis\t2\t2.6294583021926647\nCough\tGlomerulonephritis, Membranoproliferative\t1\t1.3147291510963324\nCough\tNephrotic Syndrome\t2\t2.6294583021926647\nCough\tRenal Artery Obstruction\t1\t1.3147291510963324\nCough\tRenal Insufficiency\t1\t1.3147291510963324\nCough\tAcute Kidney Injury\t4\t5.2589166043853295\nCough\tKidney Failure, Chronic\t6\t7.888374906577994\nCough\tUrethral Diseases\t1\t1.3147291510963324\nCough\tUrinary Bladder Neck Obstruction\t1\t1.3147291510963324\nCough\tUrinary Bladder, Overactive\t2\t2.6294583021926647\nCough\tUrination Disorders\t6\t7.888374906577994\nCough\tHematuria\t1\t1.3147291510963324\nCough\tOliguria\t1\t1.3147291510963324\nCough\tAlbuminuria\t2\t2.6294583021926647\nCough\tUrinary Incontinence\t28\t36.81241623069731\nCough\tUrinary Incontinence, Stress\t99\t130.1581859585369\nCough\tUrinary Incontinence, Urge\t1\t1.3147291510963324\nCough\tFemale Urogenital Diseases\t1\t1.3147291510963324\nCough\tFallopian Tube Diseases\t1\t1.3147291510963324\nCough\tAnovulation\t1\t1.3147291510963324\nCough\tOvarian Hyperstimulation Syndrome\t1\t1.3147291510963324\nCough\tEndometriosis\t4\t5.2589166043853295\nCough\tInfertility, Female\t1\t1.3147291510963324\nCough\tUterine Cervical Incompetence\t1\t1.3147291510963324\nCough\tUterine Prolapse\t4\t5.2589166043853295\nCough\tVaginal Diseases\t2\t2.6294583021926647\nCough\tPregnancy Complications\t5\t6.573645755481662\nCough\tAbruptio Placentae\t1\t1.3147291510963324\nCough\tFetal Membranes, Premature Rupture\t1\t1.3147291510963324\nCough\tPregnancy Complications, Cardiovascular\t1\t1.3147291510963324\nCough\tPregnancy in Diabetics\t1\t1.3147291510963324\nCough\tPuerperal Disorders\t3\t3.944187453288997\nCough\tCardiovascular Abnormalities\t2\t2.6294583021926647\nCough\tHeart Defects, Congenital\t1\t1.3147291510963324\nCough\tCoronary Vessel Anomalies\t1\t1.3147291510963324\nCough\tHeart Septal Defects\t1\t1.3147291510963324\nCough\tHeart Septal Defects, Atrial\t11\t14.462020662059656\nCough\tHeart Septal Defects, Ventricular\t1\t1.3147291510963324\nCough\tTetralogy of Fallot\t1\t1.3147291510963324\nCough\tTransposition of Great Vessels\t1\t1.3147291510963324\nCough\tVascular Malformations\t1\t1.3147291510963324\nCough\tArteriovenous Malformations\t2\t2.6294583021926647\nCough\tVascular Fistula\t1\t1.3147291510963324\nCough\tArterio-Arterial Fistula\t1\t1.3147291510963324\nCough\tHeart Diseases\t11\t14.462020662059656\nCough\tArrhythmias, Cardiac\t15\t19.720937266444984\nCough\tSick Sinus Syndrome\t1\t1.3147291510963324\nCough\tAtrial Fibrillation\t3\t3.944187453288997\nCough\tBradycardia\t1\t1.3147291510963324\nCough\tAtrial Premature Complexes\t3\t3.944187453288997\nCough\tVentricular Premature Complexes\t4\t5.2589166043853295\nCough\tHeart Block\t8\t10.517833208770659\nCough\tAtrioventricular Block\t3\t3.944187453288997\nCough\tLong QT Syndrome\t2\t2.6294583021926647\nCough\tTachycardia\t8\t10.517833208770659\nCough\tTachycardia, Paroxysmal\t1\t1.3147291510963324\nCough\tTachycardia, Supraventricular\t2\t2.6294583021926647\nCough\tTachycardia, Ectopic Atrial\t1\t1.3147291510963324\nCough\tTachycardia, Ventricular\t2\t2.6294583021926647\nCough\tTorsades de Pointes\t1\t1.3147291510963324\nCough\tVentricular Fibrillation\t11\t14.462020662059656\nCough\tCardiac Output, Low\t3\t3.944187453288997\nCough\tCardiac Tamponade\t1\t1.3147291510963324\nCough\tCardiomegaly\t1\t1.3147291510963324\nCough\tHypertrophy, Left Ventricular\t2\t2.6294583021926647\nCough\tHypertrophy, Right Ventricular\t1\t1.3147291510963324\nCough\tCardiomyopathies\t4\t5.2589166043853295\nCough\tCardiomyopathy, Hypertrophic\t2\t2.6294583021926647\nCough\tCardiomyopathy, Restrictive\t1\t1.3147291510963324\nCough\tMyocardial Reperfusion Injury\t1\t1.3147291510963324\nCough\tMyocarditis\t4\t5.2589166043853295\nCough\tHeart Arrest\t11\t14.462020662059656\nCough\tHeart Failure\t31\t40.756603683986306\nCough\tAortic Valve Insufficiency\t2\t2.6294583021926647\nCough\tMitral Valve Prolapse\t1\t1.3147291510963324\nCough\tMitral Valve Insufficiency\t1\t1.3147291510963324\nCough\tMitral Valve Stenosis\t4\t5.2589166043853295\nCough\tTricuspid Valve Stenosis\t1\t1.3147291510963324\nCough\tMyocardial Ischemia\t2\t2.6294583021926647\nCough\tAngina Pectoris\t2\t2.6294583021926647\nCough\tAngina, Unstable\t1\t1.3147291510963324\nCough\tCoronary Disease\t7\t9.203104057674327\nCough\tCoronary Artery Disease\t7\t9.203104057674327\nCough\tMyocardial Infarction\t13\t17.09147896425232\nCough\tShock, Cardiogenic\t2\t2.6294583021926647\nCough\tPericardial Effusion\t3\t3.944187453288997\nCough\tPericarditis\t6\t7.888374906577994\nCough\tPericarditis, Constrictive\t3\t3.944187453288997\nCough\tPneumopericardium\t3\t3.944187453288997\nCough\tPulmonary Heart Disease\t6\t7.888374906577994\nCough\tVentricular Dysfunction, Left\t5\t6.573645755481662\nCough\tTakotsubo Cardiomyopathy\t1\t1.3147291510963324\nCough\tVentricular Outflow Obstruction\t1\t1.3147291510963324\nCough\tVascular Diseases\t2\t2.6294583021926647\nCough\tAneurysm\t5\t6.573645755481662\nCough\tAneurysm, Dissecting\t4\t5.2589166043853295\nCough\tAneurysm, False\t5\t6.573645755481662\nCough\tAneurysm, Ruptured\t2\t2.6294583021926647\nCough\tAortic Rupture\t3\t3.944187453288997\nCough\tAortic Aneurysm\t3\t3.944187453288997\nCough\tAortic Aneurysm, Thoracic\t9\t11.83256235986699\nCough\tAngioedema\t9\t11.83256235986699\nCough\tAortic Diseases\t1\t1.3147291510963324\nCough\tAortitis\t2\t2.6294583021926647\nCough\tArterial Occlusive Diseases\t4\t5.2589166043853295\nCough\tArteriosclerosis\t1\t1.3147291510963324\nCough\tArteritis\t2\t2.6294583021926647\nCough\tDiabetic Angiopathies\t1\t1.3147291510963324\nCough\tDiabetic Foot\t1\t1.3147291510963324\nCough\tEmbolism\t3\t3.944187453288997\nCough\tEmbolism, Air\t13\t17.09147896425232\nCough\tEmbolism, Fat\t1\t1.3147291510963324\nCough\tEmbolism, Paradoxical\t2\t2.6294583021926647\nCough\tVenous Thromboembolism\t1\t1.3147291510963324\nCough\tThrombosis\t3\t3.944187453288997\nCough\tVenous Thrombosis\t1\t1.3147291510963324\nCough\tThrombophlebitis\t3\t3.944187453288997\nCough\tEhlers-Danlos Syndrome\t2\t2.6294583021926647\nCough\tHypertension\t93\t122.26981105195891\nCough\tHypotension\t7\t9.203104057674327\nCough\tSuperior Vena Cava Syndrome\t4\t5.2589166043853295\nCough\tVaricose Veins\t3\t3.944187453288997\nCough\tVasculitis\t3\t3.944187453288997\nCough\tMucocutaneous Lymph Node Syndrome\t7\t9.203104057674327\nCough\tPurpura, Schoenlein-Henoch\t1\t1.3147291510963324\nCough\tChurg-Strauss Syndrome\t3\t3.944187453288997\nCough\tVasculitis, Leukocytoclastic, Cutaneous\t2\t2.6294583021926647\nCough\tVenous Insufficiency\t2\t2.6294583021926647\nCough\tHematologic Diseases\t1\t1.3147291510963324\nCough\tAnemia\t5\t6.573645755481662\nCough\tAnemia, Aplastic\t1\t1.3147291510963324\nCough\tAnemia, Sickle Cell\t13\t17.09147896425232\nCough\tSickle Cell Trait\t1\t1.3147291510963324\nCough\tbeta-Thalassemia\t2\t2.6294583021926647\nCough\tAnemia, Pernicious\t1\t1.3147291510963324\nCough\tAnemia, Refractory\t1\t1.3147291510963324\nCough\tBlood Coagulation Disorders\t1\t1.3147291510963324\nCough\tHemophilia A\t1\t1.3147291510963324\nCough\tWiskott-Aldrich Syndrome\t1\t1.3147291510963324\nCough\tEcchymosis\t2\t2.6294583021926647\nCough\tPurpura\t3\t3.944187453288997\nCough\tThrombocytopenia\t1\t1.3147291510963324\nCough\tAgammaglobulinemia\t2\t2.6294583021926647\nCough\tIgG Deficiency\t1\t1.3147291510963324\nCough\tMyelodysplastic Syndromes\t1\t1.3147291510963324\nCough\tPolycythemia Vera\t3\t3.944187453288997\nCough\tEosinophilia\t48\t63.10699925262395\nCough\tAngiolymphoid Hyperplasia with Eosinophilia\t2\t2.6294583021926647\nCough\tHypereosinophilic Syndrome\t6\t7.888374906577994\nCough\tLeukocytosis\t3\t3.944187453288997\nCough\tLymphocytosis\t2\t2.6294583021926647\nCough\tChediak-Higashi Syndrome\t1\t1.3147291510963324\nCough\tGranulomatous Disease, Chronic\t2\t2.6294583021926647\nCough\tJobs Syndrome
    ## Lupus Nephritis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    0.0000000
    ## Uterine Cervical Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          0.0000000
    ## Tuberculosis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       0.3421104
    ## Silo Fillers Disease\t1\t1.3147291510963324\nCough\tAnti-Glomerular Basement Membrane Disease\t3\t3.944187453288997\nCough\tHistiocytosis, Langerhans-Cell\t10\t13.147291510963324\nCough\tIdiopathic Pulmonary Fibrosis\t29\t38.12714538179364\nCough\tPneumoconiosis\t19\t24.979853870830315\nCough\tAsbestosis\t9\t11.83256235986699\nCough\tByssinosis\t4\t5.2589166043853295\nCough\tSilicosis\t8\t10.517833208770659\nCough\tSarcoidosis, Pulmonary\t20\t26.29458302192665\nCough\tWegener Granulomatosis\t9\t11.83256235986699\nCough\tLung Diseases, Obstructive\t93\t122.26981105195891\nCough\tPulmonary Disease, Chronic Obstructive\t90\t118.3256235986699\nCough\tLung Injury\t1\t1.3147291510963324\nCough\tMeconium Aspiration Syndrome\t1\t1.3147291510963324\nCough\tBronchopulmonary Dysplasia\t2\t2.6294583021926647\nCough\tPneumonia\t95\t124.89926935415157\nCough\tPleuropneumonia\t1\t1.3147291510963324\nCough\tPneumonia, Aspiration\t35\t46.01552028837163\nCough\tPneumonia, Lipid\t5\t6.573645755481662\nCough\tPulmonary Alveolar Proteinosis\t7\t9.203104057674327\nCough\tPulmonary Atelectasis\t20\t26.29458302192665\nCough\tMiddle Lobe Syndrome\t5\t6.573645755481662\nCough\tPulmonary Edema\t21\t27.60931217302298\nCough\tPulmonary Embolism\t22\t28.92404132411931\nCough\tPulmonary Emphysema\t31\t40.756603683986306\nCough\tLung, Hyperlucent\t1\t1.3147291510963324\nCough\tPulmonary Eosinophilia\t30\t39.44187453288997\nCough\tPulmonary Fibrosis\t27\t35.49768707960097\nCough\tPulmonary Veno-Occlusive Disease\t1\t1.3147291510963324\nCough\tRespiratory Distress Syndrome, Adult\t8\t10.517833208770659\nCough\tRespiratory Distress Syndrome, Newborn\t6\t7.888374906577994\nCough\tScimitar Syndrome\t2\t2.6294583021926647\nCough\tNose Diseases\t6\t7.888374906577994\nCough\tEpistaxis\t2\t2.6294583021926647\nCough\tNasal Obstruction\t4\t5.2589166043853295\nCough\tNasal Polyps\t1\t1.3147291510963324\nCough\tParanasal Sinus Diseases\t3\t3.944187453288997\nCough\tSinusitis\t46\t60.47754095043129\nCough\tMaxillary Sinusitis\t2\t2.6294583021926647\nCough\tRhinitis\t54\t70.99537415920194\nCough\tRhinitis, Allergic, Perennial\t18\t23.66512471973398\nCough\tRhinitis, Allergic, Seasonal\t24\t31.553499626311975\nCough\tRhinitis, Atrophic\t1\t1.3147291510963324\nCough\tRhinitis, Vasomotor\t1\t1.3147291510963324\nCough\tPleural Diseases\t11\t14.462020662059656\nCough\tChylothorax\t1\t1.3147291510963324\nCough\tHydrothorax\t2\t2.6294583021926647\nCough\tPleural Effusion\t21\t27.60931217302298\nCough\tPleurisy\t9\t11.83256235986699\nCough\tPneumothorax\t23\t30.238770475215645\nCough\tRespiration Disorders\t72\t94.66049887893593\nCough\tAltitude Sickness\t5\t6.573645755481662\nCough\tApnea\t9\t11.83256235986699\nCough\tSleep Apnea Syndromes\t13\t17.09147896425232\nCough\tSleep Apnea, Central\t1\t1.3147291510963324\nCough\tSleep Apnea, Obstructive\t5\t6.573645755481662\nCough\tCough\t4598\t6045.124636740937\nCough\tDyspnea\t155\t203.78301841993152\nCough\tDyspnea, Paroxysmal\t2\t2.6294583021926647\nCough\tHyperventilation\t10\t13.147291510963324\nCough\tMouth Breathing\t2\t2.6294583021926647\nCough\tRespiratory Aspiration\t13\t17.09147896425232\nCough\tRespiratory Insufficiency\t60\t78.88374906577994\nCough\tAirway Obstruction\t70\t92.03104057674327\nCough\tHypoventilation\t2\t2.6294583021926647\nCough\tRespiratory Paralysis\t4\t5.2589166043853295\nCough\tRespiratory Hypersensitivity\t52\t68.36591585700928\nCough\tRespiratory System Abnormalities\t1\t1.3147291510963324\nCough\tBronchopulmonary Sequestration\t4\t5.2589166043853295\nCough\tRespiratory Tract Fistula\t3\t3.944187453288997\nCough\tEpiglottitis\t4\t5.2589166043853295\nCough\tTracheitis\t10\t13.147291510963324\nCough\tThoracic Diseases\t7\t9.203104057674327\nCough\tMediastinal Diseases\t8\t10.517833208770659\nCough\tMediastinal Emphysema\t20\t26.29458302192665\nCough\tMediastinitis\t1\t1.3147291510963324\nCough\tTracheal Diseases\t52\t68.36591585700928\nCough\tTracheal Stenosis\t14\t18.406208115348655\nCough\tEar Diseases\t1\t1.3147291510963324\nCough\tEarache\t2\t2.6294583021926647\nCough\tHearing Loss, Bilateral\t1\t1.3147291510963324\nCough\tHearing Loss, Functional\t1\t1.3147291510963324\nCough\tLabyrinth Diseases\t1\t1.3147291510963324\nCough\tVertigo\t1\t1.3147291510963324\nCough\tOtitis\t1\t1.3147291510963324\nCough\tOtitis Externa\t1\t1.3147291510963324\nCough\tOtitis Media\t5\t6.573645755481662\nCough\tOtitis Media with Effusion\t1\t1.3147291510963324\nCough\tMultiple Sclerosis\t6\t7.888374906577994\nCough\tMyasthenia Gravis\t1\t1.3147291510963324\nCough\tGuillain-Barre Syndrome\t2\t2.6294583021926647\nCough\tHereditary Sensory and Autonomic Neuropathies\t3\t3.944187453288997\nCough\tGiant Cell Arteritis\t26\t34.18295792850464\nCough\tAutonomic Nervous System Diseases\t4\t5.2589166043853295\nCough\tAdie Syndrome\t4\t5.2589166043853295\nCough\tHypotension, Orthostatic\t1\t1.3147291510963324\nCough\tSyncope, Vasovagal\t2\t2.6294583021926647\nCough\tCentral Nervous System Diseases\t1\t1.3147291510963324\nCough\tBrain Diseases\t3\t3.944187453288997\nCough\tParkinson Disease\t11\t14.462020662059656\nCough\tParkinson Disease, Postencephalitic\t1\t1.3147291510963324\nCough\tSupranuclear Palsy, Progressive\t1\t1.3147291510963324\nCough\tTourette Syndrome\t4\t5.2589166043853295\nCough\tCerebral Palsy\t4\t5.2589166043853295\nCough\tBrain Death\t1\t1.3147291510963324\nCough\tBrain Diseases, Metabolic, Inborn\t1\t1.3147291510963324\nCough\tGlycogen Storage Disease Type II\t2\t2.6294583021926647\nCough\tNiemann-Pick Disease, Type B\t1\t1.3147291510963324\nCough\tBrain Edema\t1\t1.3147291510963324\nCough\tBrain Injuries\t2\t2.6294583021926647\nCough\tPneumocephalus\t3\t3.944187453288997\nCough\tCerebellar Diseases\t1\t1.3147291510963324\nCough\tCerebellar Ataxia\t1\t1.3147291510963324\nCough\tAtaxia Telangiectasia\t1\t1.3147291510963324\nCough\tCerebrovascular Disorders\t7\t9.203104057674327\nCough\tBrain Ischemia\t3\t3.944187453288997\nCough\tBrain Infarction\t1\t1.3147291510963324\nCough\tBrain Stem Infarctions\t1\t1.3147291510963324\nCough\tLateral Medullary Syndrome\t1\t1.3147291510963324\nCough\tCerebral Infarction\t18\t23.66512471973398\nCough\tInfarction, Middle Cerebral Artery\t1\t1.3147291510963324\nCough\tIschemic Attack, Transient\t1\t1.3147291510963324\nCough\tCarotid Artery Diseases\t4\t5.2589166043853295\nCough\tCarotid Artery Thrombosis\t1\t1.3147291510963324\nCough\tCarotid Stenosis\t1\t1.3147291510963324\nCough\tVertebral Artery Dissection\t1\t1.3147291510963324\nCough\tIntracranial Aneurysm\t2\t2.6294583021926647\nCough\tIntracranial Arteriosclerosis\t1\t1.3147291510963324\nCough\tIntracranial Arteriovenous Malformations\t1\t1.3147291510963324\nCough\tIntracranial Embolism and Thrombosis\t2\t2.6294583021926647\nCough\tIntracranial Embolism\t3\t3.944187453288997\nCough\tCerebral Hemorrhage\t4\t5.2589166043853295\nCough\tHematoma, Epidural, Cranial\t2\t2.6294583021926647\nCough\tHematoma, Subdural\t2\t2.6294583021926647\nCough\tSubarachnoid Hemorrhage\t2\t2.6294583021926647\nCough\tStroke\t15\t19.720937266444984\nCough\tVascular Headaches\t1\t1.3147291510963324\nCough\tDementia\t1\t1.3147291510963324\nCough\tCreutzfeldt-Jakob Syndrome\t2\t2.6294583021926647\nCough\tMeningoencephalitis\t2\t2.6294583021926647\nCough\tEpilepsy\t11\t14.462020662059656\nCough\tEpilepsies, Partial\t3\t3.944187453288997\nCough\tEpilepsy, Temporal Lobe\t3\t3.944187453288997\nCough\tSeizures\t10\t13.147291510963324\nCough\tHeadache Disorders\t1\t1.3147291510963324\nCough\tHeadache Disorders, Primary\t2\t2.6294583021926647\nCough\tMigraine Disorders\t4\t5.2589166043853295\nCough\tMigraine without Aura\t1\t1.3147291510963324\nCough\tTension-Type Headache\t1\t1.3147291510963324\nCough\tCluster Headache\t2\t2.6294583021926647\nCough\tParoxysmal Hemicrania\t1\t1.3147291510963324\nCough\tHydrocephalus\t4\t5.2589166043853295\nCough\tHypoxia, Brain\t2\t2.6294583021926647\nCough\tIntracranial Hypertension\t1\t1.3147291510963324\nCough\tHypertensive Encephalopathy\t1\t1.3147291510963324\nCough\tPseudotumor Cerebri\t2\t2.6294583021926647\nCough\tIntracranial Hypotension\t2\t2.6294583021926647\nCough\tSubdural Effusion\t1\t1.3147291510963324\nCough\tMovement Disorders\t2\t2.6294583021926647\nCough\tDyskinesias\t1\t1.3147291510963324\nCough\tTorticollis\t2\t2.6294583021926647\nCough\tEssential Tremor\t1\t1.3147291510963324\nCough\tTic Disorders\t8\t10.517833208770659\nCough\tSpinal Cord Diseases\t2\t2.6294583021926647\nCough\tAmyotrophic Lateral Sclerosis\t18\t23.66512471973398\nCough\tMuscular Atrophy, Spinal\t1\t1.3147291510963324\nCough\tSpinal Muscular Atrophies of Childhood\t3\t3.944187453288997\nCough\tSpinal Cord Injuries\t18\t23.66512471973398\nCough\tSyringomyelia\t5\t6.573645755481662\nCough\tCranial Nerve Diseases\t2\t2.6294583021926647\nCough\tHypoglossal Nerve Diseases\t1\t1.3147291510963324\nCough\tNystagmus, Pathologic\t2\t2.6294583021926647\nCough\tOptic Nerve Diseases\t2\t2.6294583021926647\nCough\tOptic Neuritis\t1\t1.3147291510963324\nCough\tTrigeminal Neuralgia\t1\t1.3147291510963324\nCough\tVagus Nerve Diseases\t6\t7.888374906577994\nCough\tHereditary Sensory and Motor Neuropathy\t3\t3.944187453288997\nCough\tArnold-Chiari Malformation\t14\t18.406208115348655\nCough\tMeningocele\t1\t1.3147291510963324\nCough\tMotor Neuron Disease\t3\t3.944187453288997\nCough\tBulbar Palsy, Progressive\t2\t2.6294583021926647\nCough\tDecerebrate State\t8\t10.517833208770659\nCough\tDystonia\t1\t1.3147291510963324\nCough\tMyoclonus\t1\t1.3147291510963324\nCough\tPsychomotor Agitation\t1\t1.3147291510963324\nCough\tTics\t1\t1.3147291510963324\nCough\tLanguage Disorders\t1\t1.3147291510963324\nCough\tSpeech Disorders\t1\t1.3147291510963324\nCough\tMutism\t1\t1.3147291510963324\nCough\tConfusion\t2\t2.6294583021926647\nCough\tDelirium\t1\t1.3147291510963324\nCough\tConsciousness Disorders\t6\t7.888374906577994\nCough\tUnconsciousness\t2\t2.6294583021926647\nCough\tComa\t3\t3.944187453288997\nCough\tSyncope\t110\t144.62020662059655\nCough\tMemory Disorders\t1\t1.3147291510963324\nCough\tAmnesia\t1\t1.3147291510963324\nCough\tMental Retardation\t1\t1.3147291510963324\nCough\tDown Syndrome\t3\t3.944187453288997\nCough\tHallucinations\t2\t2.6294583021926647\nCough\tNeurogenic Inflammation\t1\t1.3147291510963324\nCough\tMuscular Atrophy\t1\t1.3147291510963324\nCough\tSpasm\t1\t1.3147291510963324\nCough\tPain\t30\t39.44187453288997\nCough\tBack Pain\t4\t5.2589166043853295\nCough\tHeadache\t43\t56.53335349714229\nCough\tNeck Pain\t1\t1.3147291510963324\nCough\tSciatica\t1\t1.3147291510963324\nCough\tParalysis\t2\t2.6294583021926647\nCough\tHemiplegia\t2\t2.6294583021926647\nCough\tParaplegia\t4\t5.2589166043853295\nCough\tQuadriplegia\t14\t18.406208115348655\nCough\tTonic Pupil\t2\t2.6294583021926647\nCough\tSensation Disorders\t1\t1.3147291510963324\nCough\tDizziness\t3\t3.944187453288997\nCough\tOlfaction Disorders\t1\t1.3147291510963324\nCough\tParesthesia\t1\t1.3147291510963324\nCough\tDysgeusia\t1\t1.3147291510963324\nCough\tVision Disorders\t1\t1.3147291510963324\nCough\tBlindness\t4\t5.2589166043853295\nCough\tNeuromuscular Diseases\t36\t47.33024943946796\nCough\tPeripheral Nervous System Diseases\t4\t5.2589166043853295\nCough\tDiabetic Neuropathies\t7\t9.203104057674327\nCough\tMononeuropathies\t1\t1.3147291510963324\nCough\tNerve Compression Syndromes\t4\t5.2589166043853295\nCough\tThoracic Outlet Syndrome\t1\t1.3147291510963324\nCough\tNeuritis\t1\t1.3147291510963324\nCough\tPOEMS Syndrome\t1\t1.3147291510963324\nCough\tNeurotoxicity Syndromes\t1\t1.3147291510963324\nCough\tArsenic Poisoning\t2\t2.6294583021926647\nCough\tSleep Disorders\t7\t9.203104057674327\nCough\tSleep Initiation and Maintenance Disorders\t4\t5.2589166043853295\nCough\tCraniocerebral Trauma\t4\t5.2589166043853295\nCough\tShaken Baby Syndrome\t1\t1.3147291510963324\nCough\tSkull Fractures\t1\t1.3147291510963324\nCough\tConjunctival Diseases\t1\t1.3147291510963324\nCough\tConjunctivitis\t4\t5.2589166043853295\nCough\tConjunctivitis, Allergic\t1\t1.3147291510963324\nCough\tKeratitis\t1\t1.3147291510963324\nCough\tChoroid Hemorrhage\t1\t1.3147291510963324\nCough\tRetinal Hemorrhage\t3\t3.944187453288997\nCough\tEyelid Diseases\t1\t1.3147291510963324\nCough\tBlepharoptosis\t1\t1.3147291510963324\nCough\tLacrimal Apparatus Diseases\t2\t2.6294583021926647\nCough\tGlaucoma\t3\t3.944187453288997\nCough\tGlaucoma, Open-Angle\t1\t1.3147291510963324\nCough\tOcular Hypotension\t1\t1.3147291510963324\nCough\tOrbital Diseases\t3\t3.944187453288997\nCough\tExophthalmos\t2\t2.6294583021926647\nCough\tMyopia\t1\t1.3147291510963324\nCough\tDiabetic Retinopathy\t1\t1.3147291510963324\nCough\tIris Diseases\t1\t1.3147291510963324\nCough\tGenital Diseases, Male\t1\t1.3147291510963324\nCough\tHemospermia\t1\t1.3147291510963324\nCough\tProstatic Hyperplasia\t2\t2.6294583021926647\nCough\tUrologic Diseases\t1\t1.3147291510963324\nCough\tKidney Diseases\t2\t2.6294583021926647\nCough\tDiabetes Insipidus\t1\t1.3147291510963324\nCough\tDiabetes Insipidus, Neurogenic\t1\t1.3147291510963324\nCough\tDiabetic Nephropathies\t1\t1.3147291510963324\nCough\tGlomerulonephritis\t2\t2.6294583021926647\nCough\tGlomerulonephritis, Membranoproliferative\t1\t1.3147291510963324\nCough\tNephrotic Syndrome\t2\t2.6294583021926647\nCough\tRenal Artery Obstruction\t1\t1.3147291510963324\nCough\tRenal Insufficiency\t1\t1.3147291510963324\nCough\tAcute Kidney Injury\t4\t5.2589166043853295\nCough\tKidney Failure, Chronic\t6\t7.888374906577994\nCough\tUrethral Diseases\t1\t1.3147291510963324\nCough\tUrinary Bladder Neck Obstruction\t1\t1.3147291510963324\nCough\tUrinary Bladder, Overactive\t2\t2.6294583021926647\nCough\tUrination Disorders\t6\t7.888374906577994\nCough\tHematuria\t1\t1.3147291510963324\nCough\tOliguria\t1\t1.3147291510963324\nCough\tAlbuminuria\t2\t2.6294583021926647\nCough\tUrinary Incontinence\t28\t36.81241623069731\nCough\tUrinary Incontinence, Stress\t99\t130.1581859585369\nCough\tUrinary Incontinence, Urge\t1\t1.3147291510963324\nCough\tFemale Urogenital Diseases\t1\t1.3147291510963324\nCough\tFallopian Tube Diseases\t1\t1.3147291510963324\nCough\tAnovulation\t1\t1.3147291510963324\nCough\tOvarian Hyperstimulation Syndrome\t1\t1.3147291510963324\nCough\tEndometriosis\t4\t5.2589166043853295\nCough\tInfertility, Female\t1\t1.3147291510963324\nCough\tUterine Cervical Incompetence\t1\t1.3147291510963324\nCough\tUterine Prolapse\t4\t5.2589166043853295\nCough\tVaginal Diseases\t2\t2.6294583021926647\nCough\tPregnancy Complications\t5\t6.573645755481662\nCough\tAbruptio Placentae\t1\t1.3147291510963324\nCough\tFetal Membranes, Premature Rupture\t1\t1.3147291510963324\nCough\tPregnancy Complications, Cardiovascular\t1\t1.3147291510963324\nCough\tPregnancy in Diabetics\t1\t1.3147291510963324\nCough\tPuerperal Disorders\t3\t3.944187453288997\nCough\tCardiovascular Abnormalities\t2\t2.6294583021926647\nCough\tHeart Defects, Congenital\t1\t1.3147291510963324\nCough\tCoronary Vessel Anomalies\t1\t1.3147291510963324\nCough\tHeart Septal Defects\t1\t1.3147291510963324\nCough\tHeart Septal Defects, Atrial\t11\t14.462020662059656\nCough\tHeart Septal Defects, Ventricular\t1\t1.3147291510963324\nCough\tTetralogy of Fallot\t1\t1.3147291510963324\nCough\tTransposition of Great Vessels\t1\t1.3147291510963324\nCough\tVascular Malformations\t1\t1.3147291510963324\nCough\tArteriovenous Malformations\t2\t2.6294583021926647\nCough\tVascular Fistula\t1\t1.3147291510963324\nCough\tArterio-Arterial Fistula\t1\t1.3147291510963324\nCough\tHeart Diseases\t11\t14.462020662059656\nCough\tArrhythmias, Cardiac\t15\t19.720937266444984\nCough\tSick Sinus Syndrome\t1\t1.3147291510963324\nCough\tAtrial Fibrillation\t3\t3.944187453288997\nCough\tBradycardia\t1\t1.3147291510963324\nCough\tAtrial Premature Complexes\t3\t3.944187453288997\nCough\tVentricular Premature Complexes\t4\t5.2589166043853295\nCough\tHeart Block\t8\t10.517833208770659\nCough\tAtrioventricular Block\t3\t3.944187453288997\nCough\tLong QT Syndrome\t2\t2.6294583021926647\nCough\tTachycardia\t8\t10.517833208770659\nCough\tTachycardia, Paroxysmal\t1\t1.3147291510963324\nCough\tTachycardia, Supraventricular\t2\t2.6294583021926647\nCough\tTachycardia, Ectopic Atrial\t1\t1.3147291510963324\nCough\tTachycardia, Ventricular\t2\t2.6294583021926647\nCough\tTorsades de Pointes\t1\t1.3147291510963324\nCough\tVentricular Fibrillation\t11\t14.462020662059656\nCough\tCardiac Output, Low\t3\t3.944187453288997\nCough\tCardiac Tamponade\t1\t1.3147291510963324\nCough\tCardiomegaly\t1\t1.3147291510963324\nCough\tHypertrophy, Left Ventricular\t2\t2.6294583021926647\nCough\tHypertrophy, Right Ventricular\t1\t1.3147291510963324\nCough\tCardiomyopathies\t4\t5.2589166043853295\nCough\tCardiomyopathy, Hypertrophic\t2\t2.6294583021926647\nCough\tCardiomyopathy, Restrictive\t1\t1.3147291510963324\nCough\tMyocardial Reperfusion Injury\t1\t1.3147291510963324\nCough\tMyocarditis\t4\t5.2589166043853295\nCough\tHeart Arrest\t11\t14.462020662059656\nCough\tHeart Failure\t31\t40.756603683986306\nCough\tAortic Valve Insufficiency\t2\t2.6294583021926647\nCough\tMitral Valve Prolapse\t1\t1.3147291510963324\nCough\tMitral Valve Insufficiency\t1\t1.3147291510963324\nCough\tMitral Valve Stenosis\t4\t5.2589166043853295\nCough\tTricuspid Valve Stenosis\t1\t1.3147291510963324\nCough\tMyocardial Ischemia\t2\t2.6294583021926647\nCough\tAngina Pectoris\t2\t2.6294583021926647\nCough\tAngina, Unstable\t1\t1.3147291510963324\nCough\tCoronary Disease\t7\t9.203104057674327\nCough\tCoronary Artery Disease\t7\t9.203104057674327\nCough\tMyocardial Infarction\t13\t17.09147896425232\nCough\tShock, Cardiogenic\t2\t2.6294583021926647\nCough\tPericardial Effusion\t3\t3.944187453288997\nCough\tPericarditis\t6\t7.888374906577994\nCough\tPericarditis, Constrictive\t3\t3.944187453288997\nCough\tPneumopericardium\t3\t3.944187453288997\nCough\tPulmonary Heart Disease\t6\t7.888374906577994\nCough\tVentricular Dysfunction, Left\t5\t6.573645755481662\nCough\tTakotsubo Cardiomyopathy\t1\t1.3147291510963324\nCough\tVentricular Outflow Obstruction\t1\t1.3147291510963324\nCough\tVascular Diseases\t2\t2.6294583021926647\nCough\tAneurysm\t5\t6.573645755481662\nCough\tAneurysm, Dissecting\t4\t5.2589166043853295\nCough\tAneurysm, False\t5\t6.573645755481662\nCough\tAneurysm, Ruptured\t2\t2.6294583021926647\nCough\tAortic Rupture\t3\t3.944187453288997\nCough\tAortic Aneurysm\t3\t3.944187453288997\nCough\tAortic Aneurysm, Thoracic\t9\t11.83256235986699\nCough\tAngioedema\t9\t11.83256235986699\nCough\tAortic Diseases\t1\t1.3147291510963324\nCough\tAortitis\t2\t2.6294583021926647\nCough\tArterial Occlusive Diseases\t4\t5.2589166043853295\nCough\tArteriosclerosis\t1\t1.3147291510963324\nCough\tArteritis\t2\t2.6294583021926647\nCough\tDiabetic Angiopathies\t1\t1.3147291510963324\nCough\tDiabetic Foot\t1\t1.3147291510963324\nCough\tEmbolism\t3\t3.944187453288997\nCough\tEmbolism, Air\t13\t17.09147896425232\nCough\tEmbolism, Fat\t1\t1.3147291510963324\nCough\tEmbolism, Paradoxical\t2\t2.6294583021926647\nCough\tVenous Thromboembolism\t1\t1.3147291510963324\nCough\tThrombosis\t3\t3.944187453288997\nCough\tVenous Thrombosis\t1\t1.3147291510963324\nCough\tThrombophlebitis\t3\t3.944187453288997\nCough\tEhlers-Danlos Syndrome\t2\t2.6294583021926647\nCough\tHypertension\t93\t122.26981105195891\nCough\tHypotension\t7\t9.203104057674327\nCough\tSuperior Vena Cava Syndrome\t4\t5.2589166043853295\nCough\tVaricose Veins\t3\t3.944187453288997\nCough\tVasculitis\t3\t3.944187453288997\nCough\tMucocutaneous Lymph Node Syndrome\t7\t9.203104057674327\nCough\tPurpura, Schoenlein-Henoch\t1\t1.3147291510963324\nCough\tChurg-Strauss Syndrome\t3\t3.944187453288997\nCough\tVasculitis, Leukocytoclastic, Cutaneous\t2\t2.6294583021926647\nCough\tVenous Insufficiency\t2\t2.6294583021926647\nCough\tHematologic Diseases\t1\t1.3147291510963324\nCough\tAnemia\t5\t6.573645755481662\nCough\tAnemia, Aplastic\t1\t1.3147291510963324\nCough\tAnemia, Sickle Cell\t13\t17.09147896425232\nCough\tSickle Cell Trait\t1\t1.3147291510963324\nCough\tbeta-Thalassemia\t2\t2.6294583021926647\nCough\tAnemia, Pernicious\t1\t1.3147291510963324\nCough\tAnemia, Refractory\t1\t1.3147291510963324\nCough\tBlood Coagulation Disorders\t1\t1.3147291510963324\nCough\tHemophilia A\t1\t1.3147291510963324\nCough\tWiskott-Aldrich Syndrome\t1\t1.3147291510963324\nCough\tEcchymosis\t2\t2.6294583021926647\nCough\tPurpura\t3\t3.944187453288997\nCough\tThrombocytopenia\t1\t1.3147291510963324\nCough\tAgammaglobulinemia\t2\t2.6294583021926647\nCough\tIgG Deficiency\t1\t1.3147291510963324\nCough\tMyelodysplastic Syndromes\t1\t1.3147291510963324\nCough\tPolycythemia Vera\t3\t3.944187453288997\nCough\tEosinophilia\t48\t63.10699925262395\nCough\tAngiolymphoid Hyperplasia with Eosinophilia\t2\t2.6294583021926647\nCough\tHypereosinophilic Syndrome\t6\t7.888374906577994\nCough\tLeukocytosis\t3\t3.944187453288997\nCough\tLymphocytosis\t2\t2.6294583021926647\nCough\tChediak-Higashi Syndrome\t1\t1.3147291510963324\nCough\tGranulomatous Disease, Chronic\t2\t2.6294583021926647\nCough\tJobs Syndrome                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1.0000000
    ## Mandibular Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                0.0000000
    ##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Mandibular Diseases
    ## Lupus Nephritis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               0.001865832
    ## Uterine Cervical Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     0.004929995
    ## Tuberculosis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  0.010256138
    ## Silo Fillers Disease\t1\t1.3147291510963324\nCough\tAnti-Glomerular Basement Membrane Disease\t3\t3.944187453288997\nCough\tHistiocytosis, Langerhans-Cell\t10\t13.147291510963324\nCough\tIdiopathic Pulmonary Fibrosis\t29\t38.12714538179364\nCough\tPneumoconiosis\t19\t24.979853870830315\nCough\tAsbestosis\t9\t11.83256235986699\nCough\tByssinosis\t4\t5.2589166043853295\nCough\tSilicosis\t8\t10.517833208770659\nCough\tSarcoidosis, Pulmonary\t20\t26.29458302192665\nCough\tWegener Granulomatosis\t9\t11.83256235986699\nCough\tLung Diseases, Obstructive\t93\t122.26981105195891\nCough\tPulmonary Disease, Chronic Obstructive\t90\t118.3256235986699\nCough\tLung Injury\t1\t1.3147291510963324\nCough\tMeconium Aspiration Syndrome\t1\t1.3147291510963324\nCough\tBronchopulmonary Dysplasia\t2\t2.6294583021926647\nCough\tPneumonia\t95\t124.89926935415157\nCough\tPleuropneumonia\t1\t1.3147291510963324\nCough\tPneumonia, Aspiration\t35\t46.01552028837163\nCough\tPneumonia, Lipid\t5\t6.573645755481662\nCough\tPulmonary Alveolar Proteinosis\t7\t9.203104057674327\nCough\tPulmonary Atelectasis\t20\t26.29458302192665\nCough\tMiddle Lobe Syndrome\t5\t6.573645755481662\nCough\tPulmonary Edema\t21\t27.60931217302298\nCough\tPulmonary Embolism\t22\t28.92404132411931\nCough\tPulmonary Emphysema\t31\t40.756603683986306\nCough\tLung, Hyperlucent\t1\t1.3147291510963324\nCough\tPulmonary Eosinophilia\t30\t39.44187453288997\nCough\tPulmonary Fibrosis\t27\t35.49768707960097\nCough\tPulmonary Veno-Occlusive Disease\t1\t1.3147291510963324\nCough\tRespiratory Distress Syndrome, Adult\t8\t10.517833208770659\nCough\tRespiratory Distress Syndrome, Newborn\t6\t7.888374906577994\nCough\tScimitar Syndrome\t2\t2.6294583021926647\nCough\tNose Diseases\t6\t7.888374906577994\nCough\tEpistaxis\t2\t2.6294583021926647\nCough\tNasal Obstruction\t4\t5.2589166043853295\nCough\tNasal Polyps\t1\t1.3147291510963324\nCough\tParanasal Sinus Diseases\t3\t3.944187453288997\nCough\tSinusitis\t46\t60.47754095043129\nCough\tMaxillary Sinusitis\t2\t2.6294583021926647\nCough\tRhinitis\t54\t70.99537415920194\nCough\tRhinitis, Allergic, Perennial\t18\t23.66512471973398\nCough\tRhinitis, Allergic, Seasonal\t24\t31.553499626311975\nCough\tRhinitis, Atrophic\t1\t1.3147291510963324\nCough\tRhinitis, Vasomotor\t1\t1.3147291510963324\nCough\tPleural Diseases\t11\t14.462020662059656\nCough\tChylothorax\t1\t1.3147291510963324\nCough\tHydrothorax\t2\t2.6294583021926647\nCough\tPleural Effusion\t21\t27.60931217302298\nCough\tPleurisy\t9\t11.83256235986699\nCough\tPneumothorax\t23\t30.238770475215645\nCough\tRespiration Disorders\t72\t94.66049887893593\nCough\tAltitude Sickness\t5\t6.573645755481662\nCough\tApnea\t9\t11.83256235986699\nCough\tSleep Apnea Syndromes\t13\t17.09147896425232\nCough\tSleep Apnea, Central\t1\t1.3147291510963324\nCough\tSleep Apnea, Obstructive\t5\t6.573645755481662\nCough\tCough\t4598\t6045.124636740937\nCough\tDyspnea\t155\t203.78301841993152\nCough\tDyspnea, Paroxysmal\t2\t2.6294583021926647\nCough\tHyperventilation\t10\t13.147291510963324\nCough\tMouth Breathing\t2\t2.6294583021926647\nCough\tRespiratory Aspiration\t13\t17.09147896425232\nCough\tRespiratory Insufficiency\t60\t78.88374906577994\nCough\tAirway Obstruction\t70\t92.03104057674327\nCough\tHypoventilation\t2\t2.6294583021926647\nCough\tRespiratory Paralysis\t4\t5.2589166043853295\nCough\tRespiratory Hypersensitivity\t52\t68.36591585700928\nCough\tRespiratory System Abnormalities\t1\t1.3147291510963324\nCough\tBronchopulmonary Sequestration\t4\t5.2589166043853295\nCough\tRespiratory Tract Fistula\t3\t3.944187453288997\nCough\tEpiglottitis\t4\t5.2589166043853295\nCough\tTracheitis\t10\t13.147291510963324\nCough\tThoracic Diseases\t7\t9.203104057674327\nCough\tMediastinal Diseases\t8\t10.517833208770659\nCough\tMediastinal Emphysema\t20\t26.29458302192665\nCough\tMediastinitis\t1\t1.3147291510963324\nCough\tTracheal Diseases\t52\t68.36591585700928\nCough\tTracheal Stenosis\t14\t18.406208115348655\nCough\tEar Diseases\t1\t1.3147291510963324\nCough\tEarache\t2\t2.6294583021926647\nCough\tHearing Loss, Bilateral\t1\t1.3147291510963324\nCough\tHearing Loss, Functional\t1\t1.3147291510963324\nCough\tLabyrinth Diseases\t1\t1.3147291510963324\nCough\tVertigo\t1\t1.3147291510963324\nCough\tOtitis\t1\t1.3147291510963324\nCough\tOtitis Externa\t1\t1.3147291510963324\nCough\tOtitis Media\t5\t6.573645755481662\nCough\tOtitis Media with Effusion\t1\t1.3147291510963324\nCough\tMultiple Sclerosis\t6\t7.888374906577994\nCough\tMyasthenia Gravis\t1\t1.3147291510963324\nCough\tGuillain-Barre Syndrome\t2\t2.6294583021926647\nCough\tHereditary Sensory and Autonomic Neuropathies\t3\t3.944187453288997\nCough\tGiant Cell Arteritis\t26\t34.18295792850464\nCough\tAutonomic Nervous System Diseases\t4\t5.2589166043853295\nCough\tAdie Syndrome\t4\t5.2589166043853295\nCough\tHypotension, Orthostatic\t1\t1.3147291510963324\nCough\tSyncope, Vasovagal\t2\t2.6294583021926647\nCough\tCentral Nervous System Diseases\t1\t1.3147291510963324\nCough\tBrain Diseases\t3\t3.944187453288997\nCough\tParkinson Disease\t11\t14.462020662059656\nCough\tParkinson Disease, Postencephalitic\t1\t1.3147291510963324\nCough\tSupranuclear Palsy, Progressive\t1\t1.3147291510963324\nCough\tTourette Syndrome\t4\t5.2589166043853295\nCough\tCerebral Palsy\t4\t5.2589166043853295\nCough\tBrain Death\t1\t1.3147291510963324\nCough\tBrain Diseases, Metabolic, Inborn\t1\t1.3147291510963324\nCough\tGlycogen Storage Disease Type II\t2\t2.6294583021926647\nCough\tNiemann-Pick Disease, Type B\t1\t1.3147291510963324\nCough\tBrain Edema\t1\t1.3147291510963324\nCough\tBrain Injuries\t2\t2.6294583021926647\nCough\tPneumocephalus\t3\t3.944187453288997\nCough\tCerebellar Diseases\t1\t1.3147291510963324\nCough\tCerebellar Ataxia\t1\t1.3147291510963324\nCough\tAtaxia Telangiectasia\t1\t1.3147291510963324\nCough\tCerebrovascular Disorders\t7\t9.203104057674327\nCough\tBrain Ischemia\t3\t3.944187453288997\nCough\tBrain Infarction\t1\t1.3147291510963324\nCough\tBrain Stem Infarctions\t1\t1.3147291510963324\nCough\tLateral Medullary Syndrome\t1\t1.3147291510963324\nCough\tCerebral Infarction\t18\t23.66512471973398\nCough\tInfarction, Middle Cerebral Artery\t1\t1.3147291510963324\nCough\tIschemic Attack, Transient\t1\t1.3147291510963324\nCough\tCarotid Artery Diseases\t4\t5.2589166043853295\nCough\tCarotid Artery Thrombosis\t1\t1.3147291510963324\nCough\tCarotid Stenosis\t1\t1.3147291510963324\nCough\tVertebral Artery Dissection\t1\t1.3147291510963324\nCough\tIntracranial Aneurysm\t2\t2.6294583021926647\nCough\tIntracranial Arteriosclerosis\t1\t1.3147291510963324\nCough\tIntracranial Arteriovenous Malformations\t1\t1.3147291510963324\nCough\tIntracranial Embolism and Thrombosis\t2\t2.6294583021926647\nCough\tIntracranial Embolism\t3\t3.944187453288997\nCough\tCerebral Hemorrhage\t4\t5.2589166043853295\nCough\tHematoma, Epidural, Cranial\t2\t2.6294583021926647\nCough\tHematoma, Subdural\t2\t2.6294583021926647\nCough\tSubarachnoid Hemorrhage\t2\t2.6294583021926647\nCough\tStroke\t15\t19.720937266444984\nCough\tVascular Headaches\t1\t1.3147291510963324\nCough\tDementia\t1\t1.3147291510963324\nCough\tCreutzfeldt-Jakob Syndrome\t2\t2.6294583021926647\nCough\tMeningoencephalitis\t2\t2.6294583021926647\nCough\tEpilepsy\t11\t14.462020662059656\nCough\tEpilepsies, Partial\t3\t3.944187453288997\nCough\tEpilepsy, Temporal Lobe\t3\t3.944187453288997\nCough\tSeizures\t10\t13.147291510963324\nCough\tHeadache Disorders\t1\t1.3147291510963324\nCough\tHeadache Disorders, Primary\t2\t2.6294583021926647\nCough\tMigraine Disorders\t4\t5.2589166043853295\nCough\tMigraine without Aura\t1\t1.3147291510963324\nCough\tTension-Type Headache\t1\t1.3147291510963324\nCough\tCluster Headache\t2\t2.6294583021926647\nCough\tParoxysmal Hemicrania\t1\t1.3147291510963324\nCough\tHydrocephalus\t4\t5.2589166043853295\nCough\tHypoxia, Brain\t2\t2.6294583021926647\nCough\tIntracranial Hypertension\t1\t1.3147291510963324\nCough\tHypertensive Encephalopathy\t1\t1.3147291510963324\nCough\tPseudotumor Cerebri\t2\t2.6294583021926647\nCough\tIntracranial Hypotension\t2\t2.6294583021926647\nCough\tSubdural Effusion\t1\t1.3147291510963324\nCough\tMovement Disorders\t2\t2.6294583021926647\nCough\tDyskinesias\t1\t1.3147291510963324\nCough\tTorticollis\t2\t2.6294583021926647\nCough\tEssential Tremor\t1\t1.3147291510963324\nCough\tTic Disorders\t8\t10.517833208770659\nCough\tSpinal Cord Diseases\t2\t2.6294583021926647\nCough\tAmyotrophic Lateral Sclerosis\t18\t23.66512471973398\nCough\tMuscular Atrophy, Spinal\t1\t1.3147291510963324\nCough\tSpinal Muscular Atrophies of Childhood\t3\t3.944187453288997\nCough\tSpinal Cord Injuries\t18\t23.66512471973398\nCough\tSyringomyelia\t5\t6.573645755481662\nCough\tCranial Nerve Diseases\t2\t2.6294583021926647\nCough\tHypoglossal Nerve Diseases\t1\t1.3147291510963324\nCough\tNystagmus, Pathologic\t2\t2.6294583021926647\nCough\tOptic Nerve Diseases\t2\t2.6294583021926647\nCough\tOptic Neuritis\t1\t1.3147291510963324\nCough\tTrigeminal Neuralgia\t1\t1.3147291510963324\nCough\tVagus Nerve Diseases\t6\t7.888374906577994\nCough\tHereditary Sensory and Motor Neuropathy\t3\t3.944187453288997\nCough\tArnold-Chiari Malformation\t14\t18.406208115348655\nCough\tMeningocele\t1\t1.3147291510963324\nCough\tMotor Neuron Disease\t3\t3.944187453288997\nCough\tBulbar Palsy, Progressive\t2\t2.6294583021926647\nCough\tDecerebrate State\t8\t10.517833208770659\nCough\tDystonia\t1\t1.3147291510963324\nCough\tMyoclonus\t1\t1.3147291510963324\nCough\tPsychomotor Agitation\t1\t1.3147291510963324\nCough\tTics\t1\t1.3147291510963324\nCough\tLanguage Disorders\t1\t1.3147291510963324\nCough\tSpeech Disorders\t1\t1.3147291510963324\nCough\tMutism\t1\t1.3147291510963324\nCough\tConfusion\t2\t2.6294583021926647\nCough\tDelirium\t1\t1.3147291510963324\nCough\tConsciousness Disorders\t6\t7.888374906577994\nCough\tUnconsciousness\t2\t2.6294583021926647\nCough\tComa\t3\t3.944187453288997\nCough\tSyncope\t110\t144.62020662059655\nCough\tMemory Disorders\t1\t1.3147291510963324\nCough\tAmnesia\t1\t1.3147291510963324\nCough\tMental Retardation\t1\t1.3147291510963324\nCough\tDown Syndrome\t3\t3.944187453288997\nCough\tHallucinations\t2\t2.6294583021926647\nCough\tNeurogenic Inflammation\t1\t1.3147291510963324\nCough\tMuscular Atrophy\t1\t1.3147291510963324\nCough\tSpasm\t1\t1.3147291510963324\nCough\tPain\t30\t39.44187453288997\nCough\tBack Pain\t4\t5.2589166043853295\nCough\tHeadache\t43\t56.53335349714229\nCough\tNeck Pain\t1\t1.3147291510963324\nCough\tSciatica\t1\t1.3147291510963324\nCough\tParalysis\t2\t2.6294583021926647\nCough\tHemiplegia\t2\t2.6294583021926647\nCough\tParaplegia\t4\t5.2589166043853295\nCough\tQuadriplegia\t14\t18.406208115348655\nCough\tTonic Pupil\t2\t2.6294583021926647\nCough\tSensation Disorders\t1\t1.3147291510963324\nCough\tDizziness\t3\t3.944187453288997\nCough\tOlfaction Disorders\t1\t1.3147291510963324\nCough\tParesthesia\t1\t1.3147291510963324\nCough\tDysgeusia\t1\t1.3147291510963324\nCough\tVision Disorders\t1\t1.3147291510963324\nCough\tBlindness\t4\t5.2589166043853295\nCough\tNeuromuscular Diseases\t36\t47.33024943946796\nCough\tPeripheral Nervous System Diseases\t4\t5.2589166043853295\nCough\tDiabetic Neuropathies\t7\t9.203104057674327\nCough\tMononeuropathies\t1\t1.3147291510963324\nCough\tNerve Compression Syndromes\t4\t5.2589166043853295\nCough\tThoracic Outlet Syndrome\t1\t1.3147291510963324\nCough\tNeuritis\t1\t1.3147291510963324\nCough\tPOEMS Syndrome\t1\t1.3147291510963324\nCough\tNeurotoxicity Syndromes\t1\t1.3147291510963324\nCough\tArsenic Poisoning\t2\t2.6294583021926647\nCough\tSleep Disorders\t7\t9.203104057674327\nCough\tSleep Initiation and Maintenance Disorders\t4\t5.2589166043853295\nCough\tCraniocerebral Trauma\t4\t5.2589166043853295\nCough\tShaken Baby Syndrome\t1\t1.3147291510963324\nCough\tSkull Fractures\t1\t1.3147291510963324\nCough\tConjunctival Diseases\t1\t1.3147291510963324\nCough\tConjunctivitis\t4\t5.2589166043853295\nCough\tConjunctivitis, Allergic\t1\t1.3147291510963324\nCough\tKeratitis\t1\t1.3147291510963324\nCough\tChoroid Hemorrhage\t1\t1.3147291510963324\nCough\tRetinal Hemorrhage\t3\t3.944187453288997\nCough\tEyelid Diseases\t1\t1.3147291510963324\nCough\tBlepharoptosis\t1\t1.3147291510963324\nCough\tLacrimal Apparatus Diseases\t2\t2.6294583021926647\nCough\tGlaucoma\t3\t3.944187453288997\nCough\tGlaucoma, Open-Angle\t1\t1.3147291510963324\nCough\tOcular Hypotension\t1\t1.3147291510963324\nCough\tOrbital Diseases\t3\t3.944187453288997\nCough\tExophthalmos\t2\t2.6294583021926647\nCough\tMyopia\t1\t1.3147291510963324\nCough\tDiabetic Retinopathy\t1\t1.3147291510963324\nCough\tIris Diseases\t1\t1.3147291510963324\nCough\tGenital Diseases, Male\t1\t1.3147291510963324\nCough\tHemospermia\t1\t1.3147291510963324\nCough\tProstatic Hyperplasia\t2\t2.6294583021926647\nCough\tUrologic Diseases\t1\t1.3147291510963324\nCough\tKidney Diseases\t2\t2.6294583021926647\nCough\tDiabetes Insipidus\t1\t1.3147291510963324\nCough\tDiabetes Insipidus, Neurogenic\t1\t1.3147291510963324\nCough\tDiabetic Nephropathies\t1\t1.3147291510963324\nCough\tGlomerulonephritis\t2\t2.6294583021926647\nCough\tGlomerulonephritis, Membranoproliferative\t1\t1.3147291510963324\nCough\tNephrotic Syndrome\t2\t2.6294583021926647\nCough\tRenal Artery Obstruction\t1\t1.3147291510963324\nCough\tRenal Insufficiency\t1\t1.3147291510963324\nCough\tAcute Kidney Injury\t4\t5.2589166043853295\nCough\tKidney Failure, Chronic\t6\t7.888374906577994\nCough\tUrethral Diseases\t1\t1.3147291510963324\nCough\tUrinary Bladder Neck Obstruction\t1\t1.3147291510963324\nCough\tUrinary Bladder, Overactive\t2\t2.6294583021926647\nCough\tUrination Disorders\t6\t7.888374906577994\nCough\tHematuria\t1\t1.3147291510963324\nCough\tOliguria\t1\t1.3147291510963324\nCough\tAlbuminuria\t2\t2.6294583021926647\nCough\tUrinary Incontinence\t28\t36.81241623069731\nCough\tUrinary Incontinence, Stress\t99\t130.1581859585369\nCough\tUrinary Incontinence, Urge\t1\t1.3147291510963324\nCough\tFemale Urogenital Diseases\t1\t1.3147291510963324\nCough\tFallopian Tube Diseases\t1\t1.3147291510963324\nCough\tAnovulation\t1\t1.3147291510963324\nCough\tOvarian Hyperstimulation Syndrome\t1\t1.3147291510963324\nCough\tEndometriosis\t4\t5.2589166043853295\nCough\tInfertility, Female\t1\t1.3147291510963324\nCough\tUterine Cervical Incompetence\t1\t1.3147291510963324\nCough\tUterine Prolapse\t4\t5.2589166043853295\nCough\tVaginal Diseases\t2\t2.6294583021926647\nCough\tPregnancy Complications\t5\t6.573645755481662\nCough\tAbruptio Placentae\t1\t1.3147291510963324\nCough\tFetal Membranes, Premature Rupture\t1\t1.3147291510963324\nCough\tPregnancy Complications, Cardiovascular\t1\t1.3147291510963324\nCough\tPregnancy in Diabetics\t1\t1.3147291510963324\nCough\tPuerperal Disorders\t3\t3.944187453288997\nCough\tCardiovascular Abnormalities\t2\t2.6294583021926647\nCough\tHeart Defects, Congenital\t1\t1.3147291510963324\nCough\tCoronary Vessel Anomalies\t1\t1.3147291510963324\nCough\tHeart Septal Defects\t1\t1.3147291510963324\nCough\tHeart Septal Defects, Atrial\t11\t14.462020662059656\nCough\tHeart Septal Defects, Ventricular\t1\t1.3147291510963324\nCough\tTetralogy of Fallot\t1\t1.3147291510963324\nCough\tTransposition of Great Vessels\t1\t1.3147291510963324\nCough\tVascular Malformations\t1\t1.3147291510963324\nCough\tArteriovenous Malformations\t2\t2.6294583021926647\nCough\tVascular Fistula\t1\t1.3147291510963324\nCough\tArterio-Arterial Fistula\t1\t1.3147291510963324\nCough\tHeart Diseases\t11\t14.462020662059656\nCough\tArrhythmias, Cardiac\t15\t19.720937266444984\nCough\tSick Sinus Syndrome\t1\t1.3147291510963324\nCough\tAtrial Fibrillation\t3\t3.944187453288997\nCough\tBradycardia\t1\t1.3147291510963324\nCough\tAtrial Premature Complexes\t3\t3.944187453288997\nCough\tVentricular Premature Complexes\t4\t5.2589166043853295\nCough\tHeart Block\t8\t10.517833208770659\nCough\tAtrioventricular Block\t3\t3.944187453288997\nCough\tLong QT Syndrome\t2\t2.6294583021926647\nCough\tTachycardia\t8\t10.517833208770659\nCough\tTachycardia, Paroxysmal\t1\t1.3147291510963324\nCough\tTachycardia, Supraventricular\t2\t2.6294583021926647\nCough\tTachycardia, Ectopic Atrial\t1\t1.3147291510963324\nCough\tTachycardia, Ventricular\t2\t2.6294583021926647\nCough\tTorsades de Pointes\t1\t1.3147291510963324\nCough\tVentricular Fibrillation\t11\t14.462020662059656\nCough\tCardiac Output, Low\t3\t3.944187453288997\nCough\tCardiac Tamponade\t1\t1.3147291510963324\nCough\tCardiomegaly\t1\t1.3147291510963324\nCough\tHypertrophy, Left Ventricular\t2\t2.6294583021926647\nCough\tHypertrophy, Right Ventricular\t1\t1.3147291510963324\nCough\tCardiomyopathies\t4\t5.2589166043853295\nCough\tCardiomyopathy, Hypertrophic\t2\t2.6294583021926647\nCough\tCardiomyopathy, Restrictive\t1\t1.3147291510963324\nCough\tMyocardial Reperfusion Injury\t1\t1.3147291510963324\nCough\tMyocarditis\t4\t5.2589166043853295\nCough\tHeart Arrest\t11\t14.462020662059656\nCough\tHeart Failure\t31\t40.756603683986306\nCough\tAortic Valve Insufficiency\t2\t2.6294583021926647\nCough\tMitral Valve Prolapse\t1\t1.3147291510963324\nCough\tMitral Valve Insufficiency\t1\t1.3147291510963324\nCough\tMitral Valve Stenosis\t4\t5.2589166043853295\nCough\tTricuspid Valve Stenosis\t1\t1.3147291510963324\nCough\tMyocardial Ischemia\t2\t2.6294583021926647\nCough\tAngina Pectoris\t2\t2.6294583021926647\nCough\tAngina, Unstable\t1\t1.3147291510963324\nCough\tCoronary Disease\t7\t9.203104057674327\nCough\tCoronary Artery Disease\t7\t9.203104057674327\nCough\tMyocardial Infarction\t13\t17.09147896425232\nCough\tShock, Cardiogenic\t2\t2.6294583021926647\nCough\tPericardial Effusion\t3\t3.944187453288997\nCough\tPericarditis\t6\t7.888374906577994\nCough\tPericarditis, Constrictive\t3\t3.944187453288997\nCough\tPneumopericardium\t3\t3.944187453288997\nCough\tPulmonary Heart Disease\t6\t7.888374906577994\nCough\tVentricular Dysfunction, Left\t5\t6.573645755481662\nCough\tTakotsubo Cardiomyopathy\t1\t1.3147291510963324\nCough\tVentricular Outflow Obstruction\t1\t1.3147291510963324\nCough\tVascular Diseases\t2\t2.6294583021926647\nCough\tAneurysm\t5\t6.573645755481662\nCough\tAneurysm, Dissecting\t4\t5.2589166043853295\nCough\tAneurysm, False\t5\t6.573645755481662\nCough\tAneurysm, Ruptured\t2\t2.6294583021926647\nCough\tAortic Rupture\t3\t3.944187453288997\nCough\tAortic Aneurysm\t3\t3.944187453288997\nCough\tAortic Aneurysm, Thoracic\t9\t11.83256235986699\nCough\tAngioedema\t9\t11.83256235986699\nCough\tAortic Diseases\t1\t1.3147291510963324\nCough\tAortitis\t2\t2.6294583021926647\nCough\tArterial Occlusive Diseases\t4\t5.2589166043853295\nCough\tArteriosclerosis\t1\t1.3147291510963324\nCough\tArteritis\t2\t2.6294583021926647\nCough\tDiabetic Angiopathies\t1\t1.3147291510963324\nCough\tDiabetic Foot\t1\t1.3147291510963324\nCough\tEmbolism\t3\t3.944187453288997\nCough\tEmbolism, Air\t13\t17.09147896425232\nCough\tEmbolism, Fat\t1\t1.3147291510963324\nCough\tEmbolism, Paradoxical\t2\t2.6294583021926647\nCough\tVenous Thromboembolism\t1\t1.3147291510963324\nCough\tThrombosis\t3\t3.944187453288997\nCough\tVenous Thrombosis\t1\t1.3147291510963324\nCough\tThrombophlebitis\t3\t3.944187453288997\nCough\tEhlers-Danlos Syndrome\t2\t2.6294583021926647\nCough\tHypertension\t93\t122.26981105195891\nCough\tHypotension\t7\t9.203104057674327\nCough\tSuperior Vena Cava Syndrome\t4\t5.2589166043853295\nCough\tVaricose Veins\t3\t3.944187453288997\nCough\tVasculitis\t3\t3.944187453288997\nCough\tMucocutaneous Lymph Node Syndrome\t7\t9.203104057674327\nCough\tPurpura, Schoenlein-Henoch\t1\t1.3147291510963324\nCough\tChurg-Strauss Syndrome\t3\t3.944187453288997\nCough\tVasculitis, Leukocytoclastic, Cutaneous\t2\t2.6294583021926647\nCough\tVenous Insufficiency\t2\t2.6294583021926647\nCough\tHematologic Diseases\t1\t1.3147291510963324\nCough\tAnemia\t5\t6.573645755481662\nCough\tAnemia, Aplastic\t1\t1.3147291510963324\nCough\tAnemia, Sickle Cell\t13\t17.09147896425232\nCough\tSickle Cell Trait\t1\t1.3147291510963324\nCough\tbeta-Thalassemia\t2\t2.6294583021926647\nCough\tAnemia, Pernicious\t1\t1.3147291510963324\nCough\tAnemia, Refractory\t1\t1.3147291510963324\nCough\tBlood Coagulation Disorders\t1\t1.3147291510963324\nCough\tHemophilia A\t1\t1.3147291510963324\nCough\tWiskott-Aldrich Syndrome\t1\t1.3147291510963324\nCough\tEcchymosis\t2\t2.6294583021926647\nCough\tPurpura\t3\t3.944187453288997\nCough\tThrombocytopenia\t1\t1.3147291510963324\nCough\tAgammaglobulinemia\t2\t2.6294583021926647\nCough\tIgG Deficiency\t1\t1.3147291510963324\nCough\tMyelodysplastic Syndromes\t1\t1.3147291510963324\nCough\tPolycythemia Vera\t3\t3.944187453288997\nCough\tEosinophilia\t48\t63.10699925262395\nCough\tAngiolymphoid Hyperplasia with Eosinophilia\t2\t2.6294583021926647\nCough\tHypereosinophilic Syndrome\t6\t7.888374906577994\nCough\tLeukocytosis\t3\t3.944187453288997\nCough\tLymphocytosis\t2\t2.6294583021926647\nCough\tChediak-Higashi Syndrome\t1\t1.3147291510963324\nCough\tGranulomatous Disease, Chronic\t2\t2.6294583021926647\nCough\tJobs Syndrome         0.000000000
    ## Mandibular Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           1.000000000

# 4 Function-based methods

## 4.1 BOG

BOG [4] is a method for disease similarity calculating only using disease-gene associations. We designed function BOG to implement this method. And for the purpose of normalizing the matrix produced by method BOG, we implemented function Normalize. For example:

    data(d2g_separation) #get disease-gene associations
    ds<-sample(names(d2g_separation),5)
    ds

    ## [1] "joint diseases"             "insulin resistance"
    ## [3] "connective tissue diseases" "retinal dystrophies"
    ## [5] "anemia"

    sim<-BOG(ds,ds,d2g_separation)
    Normalize(sim) #normalize BOG sim scores

    ##                            joint diseases insulin resistance
    ## joint diseases                  0.7899751                  0
    ## insulin resistance              0.0000000                  1
    ## connective tissue diseases      0.1174956                  0
    ## retinal dystrophies             0.0000000                  0
    ## anemia                          0.0000000                  0
    ##                            connective tissue diseases retinal dystrophies
    ## joint diseases                            0.117495563           0.0000000
    ## insulin resistance                        0.000000000           0.0000000
    ## connective tissue diseases                0.632504738           0.0000000
    ## retinal dystrophies                       0.000000000           0.8837116
    ## anemia                                    0.001490542           0.0000000
    ##                                 anemia
    ## joint diseases             0.000000000
    ## insulin resistance         0.000000000
    ## connective tissue diseases 0.001490542
    ## retinal dystrophies        0.000000000
    ## anemia                     0.928517902

Note that disease-gene associations d2g_separation is a list object that can be obtained by function x2y_df2list. Function x2y_df2list take a data.frame which has two columns (one column contains disease ids and one column contains gene ids, each row declares an association between a disease and a gene) as a input. See an example below:

    options(stringsAsFactors = FALSE) #this may be neccessary

    d2g_fundo_sample<-read.table(text = "DOID:5218    IL6
    DOID:8649  EGFR
    DOID:8649   PTGS2
    DOID:8649   VHL
    DOID:8649   ERBB2
    DOID:8649   PDCD1
    DOID:8649   KLRC1
    DOID:5214   MPZ
    DOID:5214   EGR2
    DOID:5210   AMH")

    d2g_fundo_list<-x2y_df2list(d2g_fundo_sample)
    d2g_fundo_list

    ## $`DOID:5218`
    ## [1] "IL6"
    ##
    ## $`DOID:8649`
    ## [1] "EGFR"  "PTGS2" "VHL"   "ERBB2" "PDCD1" "KLRC1"
    ##
    ## $`DOID:5214`
    ## [1] "MPZ"  "EGR2"
    ##
    ## $`DOID:5210`
    ## [1] "AMH"

Function Normalize normalize a matrix or a vector as the following formula: \[NormScore=\frac{OrigScore-MinScore}{MaxScore-MinScore}\]

Here’s an example:

    m<-matrix(1:9,3,3)
    m

    ##      [,1] [,2] [,3]
    ## [1,]    1    4    7
    ## [2,]    2    5    8
    ## [3,]    3    6    9

    Normalize(m)

    ##       [,1]  [,2]  [,3]
    ## [1,] 0.000 0.375 0.750
    ## [2,] 0.125 0.500 0.875
    ## [3,] 0.250 0.625 1.000

## 4.2 PSB

PSB [5] uses not only disease-gene associations but also GO-gene associations. We designed function PSB to implement this method. Function PSB needs disease-GO associations which can be obtained by function HypergeometricTest.

Here’s an example for PSB:

    ## get the data
    data(go2g_sample)
    data(d2go_sample)

    ds<-names(d2go_sample)
    sim<-PSB(ds,ds,d2go_sample,go2g_sample)
    sim

    ##            DOID:5652 DOID:10005  DOID:2290
    ## DOID:5652  4.1743210 0.44099253 0.51055413
    ## DOID:10005 0.4409925 5.82708131 0.09897865
    ## DOID:2290  0.5105541 0.09897865 5.45446576

    Normalize(sim)

    ##             DOID:5652 DOID:10005  DOID:2290
    ## DOID:5652  0.71146461 0.05970806 0.07185197
    ## DOID:10005 0.05970806 1.00000000 0.00000000
    ## DOID:2290  0.07185197 0.00000000 0.93494957

## 4.3 FunSim

FunSim [3] is a method that takes advantage of gene function network data from HumanNet [6]. First we got the raw data from HumanNet, then we normalized the associated log likelihood score of gene pairs. Then we can use function FunSim to mearsure similarity between diseases (note that we use function LLSn2List to convert HumanNet data from data.frame to list, for more efficient calculating):

    ## in this method, we must use disease-gene associations
    ## which genes are represented by entrez ids because of
    ## HumanNet
    data(d2g_fundo_entrezid) ##get disease-gene associations
    data(HumanNet_sample)
    ## we specified 5 DOIDs to match Human_sample
    ds<-c("DOID:8176","DOID:2394","DOID:3744","DOID:8466","DOID:5679")
    llsnlist<-LLSn2List(HumanNet_sample)
    FunSim(ds,ds,d2g_fundo_entrezid,llsnlist)

    ##              DOID:8176  DOID:2394    DOID:3744    DOID:8466 DOID:5679
    ## DOID:8176 1.0000000000 0.43350044 0.4476822789 0.0002666029 0.1457867
    ## DOID:2394 0.4335004444 1.00000000 0.4222353572 0.0166884115 0.1592188
    ## DOID:3744 0.4476822789 0.42223536 1.0000000000 0.0001286379 0.1293250
    ## DOID:8466 0.0002666029 0.01668841 0.0001286379 1.0000000000 0.1349979
    ## DOID:5679 0.1457866621 0.15921884 0.1293250308 0.1349979009 1.0000000

## 4.4 ICod

ICod [7] mearsures disease-disease similarities based on disease-related PPIs. We used an R graph igraph to import PPI data into R. For example:

    ## get disease-gene associations and HPRD PPI data
    data(d2g_fundo_symbol)
    data(PPI_HPRD)

    graph_hprd<-graph.data.frame(PPI_HPRD,directed=FALSE) #get a igraph object based on HPRD PPI data

    ds<-sample(names(d2g_fundo_symbol),5)
    ICod(ds,ds,d2g_fundo_symbol,graph_hprd)

    ##             DOID:13359  DOID:10130    DOID:630   DOID:2528  DOID:10629
    ## DOID:13359 1.000000000 0.000000000 0.013605394 0.004129557 0.000000000
    ## DOID:10130 0.000000000 1.000000000 0.006250387 0.010174617 0.000000000
    ## DOID:630   0.013605394 0.006250387 1.000000000 0.005786591 0.004238441
    ## DOID:2528  0.004129557 0.010174617 0.005786591 1.000000000 0.000000000
    ## DOID:10629 0.000000000 0.000000000 0.004238441 0.000000000 1.000000000

## 4.5 Sun’s measures

Sun [8] proposed three measures which use different biological information. These three measures are: annotation-baesd, function-based and topological-based.

### 4.5.1 Sun’s annotation-based measure

Sun’s annotation-based measure used the information of disease-gene association data. We implemented function Sun_annotation to calculate disease-disease similarity:

    data(d2g_separation) ## get disease-gene associations

    ds<-sample(names(d2g_separation),5)
    Sun_annotation(ds,ds,d2g_separation)

    ##                                        mitochondrial diseases
    ## mitochondrial diseases                             1.00000000
    ## leukemia, lymphocytic, chronic, b-cell             0.00000000
    ## lymphatic diseases                                 0.00000000
    ## intellectual disability                            0.01265823
    ## central nervous system diseases                    0.05183585
    ##                                        leukemia, lymphocytic, chronic, b-cell
    ## mitochondrial diseases                                            0.000000000
    ## leukemia, lymphocytic, chronic, b-cell                            1.000000000
    ## lymphatic diseases                                                0.154929577
    ## intellectual disability                                           0.008196721
    ## central nervous system diseases                                   0.004464286
    ##                                        lymphatic diseases
    ## mitochondrial diseases                        0.000000000
    ## leukemia, lymphocytic, chronic, b-cell        0.154929577
    ## lymphatic diseases                            1.000000000
    ## intellectual disability                       0.004132231
    ## central nervous system diseases               0.014234875
    ##                                        intellectual disability
    ## mitochondrial diseases                             0.012658228
    ## leukemia, lymphocytic, chronic, b-cell             0.008196721
    ## lymphatic diseases                                 0.004132231
    ## intellectual disability                            1.000000000
    ## central nervous system diseases                    0.017307692
    ##                                        central nervous system diseases
    ## mitochondrial diseases                                     0.051835853
    ## leukemia, lymphocytic, chronic, b-cell                     0.004464286
    ## lymphatic diseases                                         0.014234875
    ## intellectual disability                                    0.017307692
    ## central nervous system diseases                            1.000000000

### 4.5.2 Sun’s function-based measure

Sun’s function-based measure uses both GO term annotations and disease-gene associations to estimate the disease similarity scores. We implemented function Sun_function to perform this method like follows:

    ## get a sample of disease-GO associations
    data(d2go_sample)
    ds<-names(d2go_sample)
    Sun_function(ds,ds,d2go_sample)

    ##             DOID:5652 DOID:10005  DOID:2290
    ## DOID:5652  1.00000000          0 0.02672606
    ## DOID:10005 0.00000000          1 0.00000000
    ## DOID:2290  0.02672606          0 1.00000000

### 4.5.3 Sun’s topology-based measure

Sun’s topology-based measure takes advantage of the topology of PPI network and disease-gene association data to measure disease similarity scores. Futhurmore Function Sun_topology was implemented for this method. And in this method, the graphlet signature of nodes in PPI were calculated by a tool orca [9] (see details in [8]).

Here is an example:

    data(d2g_fundo_symbol)
    data(graphlet_sig_hprd) #get graphlet signatures of genes in HPRD PPI network
    data(weight)
    ds<-sample(names(d2g_fundo_symbol),5)
    Sun_topology(ds,ds,d2g_fundo_symbol,graphlet_sig_hprd,weight)

    ##            DOID:8580 DOID:10530 DOID:2141 DOID:3005  DOID:769
    ## DOID:8580  1.0000000  0.3762668 0.3971859 0.4465814 0.4455113
    ## DOID:10530 0.3762668  1.0000000 0.4078183 0.4120618 0.4619584
    ## DOID:2141  0.3971859  0.4078183 1.0000000 0.3790711 0.5000000
    ## DOID:3005  0.4465814  0.4120618 0.3790711 1.0000000 0.5000000
    ## DOID:769   0.4455113  0.4619584 0.5000000 0.5000000 1.0000000

## 4.6 Separation

Method Separation is actually a method measuring a netowrk-based separation of disease pairs [10]. But the result can also be turned into similarity scores. And we implemented function Separation2Similarity for this purpose as the following formula: \[SimScore=\frac{MaxSepScore-SepScore}{MaxSepScore-MinSepScore}\]

Here is an example:

    ## get the disease-gene association data and interactome data
    data(d2g_separation)
    data(interactome)

    ## import ppi data to R by igraph
    graph_interactome<-graph.data.frame(interactome,directed=FALSE)

    ## calculate separation of 5 sample diseases
    ds<-sample(names(d2g_separation),5)
    sep<-Separation(ds,ds,d2g_separation,graph_interactome)

    ## convert separation into simialrity
    sim<-Separation2Similarity(sep)
    sim

    ##                              arrhythmias, cardiac urogenital neoplasms
    ## arrhythmias, cardiac                   0.98758776           0.05742388
    ## urogenital neoplasms                   0.05742388           0.88305820
    ## respiratory hypersensitivity           0.09025555           0.14995582
    ## body weight                            0.09618215           0.03241419
    ## cardiomyopathy, dilated                0.16559761           0.07113121
    ##                              respiratory hypersensitivity body weight
    ## arrhythmias, cardiac                           0.09025555 0.096182154
    ## urogenital neoplasms                           0.14995582 0.032414186
    ## respiratory hypersensitivity                   1.00000000 0.000000000
    ## body weight                                    0.00000000 0.971356361
    ## cardiomyopathy, dilated                        0.04397615 0.006761813
    ##                              cardiomyopathy, dilated
    ## arrhythmias, cardiac                     0.165597614
    ## urogenital neoplasms                     0.071131207
    ## respiratory hypersensitivity             0.043976151
    ## body weight                              0.006761813
    ## cardiomyopathy, dilated                  0.833076722

# 5 Visualization

## 5.1 Visualization of disease-gene associations

Disease-gene associations are the most widely used information to measure disease similarity in function-based methods. Here we provide function plot_bipartite for users to observe associations between diseases and genes more intuitively. This function can also visualize other associations like disease-GO term associations. Here’s an example:

    data(d2g_fundo_symbol)
    d2g_sample<-d2g_fundo_symbol[1:10]
    plot_bipartite(d2g_sample)

For two specific diseases, we implemented function plot_topo to visualize the topological relationship of the two diseases’ gene sets in gene network. The following is an example:

    data("PPI_HPRD")
    g<-graph.data.frame(PPI_HPRD,directed = FALSE) #get an igraph graph

    data(d2g_fundo_symbol)
    a<-d2g_fundo_symbol[["DOID:8242"]] # get gene set a
    b<-d2g_fundo_symbol[["DOID:4914"]] # get gene set b

    plot_topo(a,b,g)

## 5.2 Visualization of disease similarity network

We implemented two functions plot_heatmap and plot_net for the disease similarity network’s visualization. Function plot_heatmap is a reuse of function simplot in package DOSE [11] which shows the heatmap of disease similarity network. Given a cutoff, function plot_net will show the relationships among diseases in a graph. For example:

    data(d2g_separation)
    data(interactome)

    graph_interactome<-graph.data.frame(interactome,directed=FALSE)
    ds<-c("myocardial ischemia","myocardial infarction","coronary artery disease",
     "cerebrovascular disorders","arthritis, rheumatoid","diabetes mellitus, type 1",
     "autoimmune diseases of the nervous system","demyelinating autoimmune diseases, cns",
     "respiratory hypersensitivity","asthma","retinitis pigmentosa",
     "retinal degeneration","macular degeneration")

    sep<-Separation(ds,ds,d2g_separation,graph_interactome)
    sim<-Separation2Similarity(sep)
    plot_heatmap(sim,font.size = 3)

    plot_net(sim,cutoff=0.2)

# 6 References

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