load_tf_regulon_dorothea {cosmosR} | R Documentation

## load transcription factor regulon

### Description

load the transcription factors from `DOROTHEA` package and converts gene symbols to EntrezID using org.Hs.eg.db

### Usage

    load_tf_regulon_dorothea(toEntrez = TRUE, confidence = c("A", "B", "C"))

### Arguments

`toEntrez` | if TRUE (default), converts gene symbols to EntrezID
`confidence` | strong vector (by default: c("A","B","C")). Subset of {A, B, C, D, E}. See the 'dorothea' for the meaning of confidence levels. package for further details.

### Value

returns a PKN of a form of a data table. Each row is an interaction. Columns names are:

- 'tf' transcription factor - 'confidence' class of confidence - 'target' target gene - 'sign' indicates if interaction is up (1) or down-regulation (-1).

### Examples

    load_tf_regulon_dorothea()

[Package cosmosR version 1.2.0 Index]