Package: NoRCE
Type: Package
Title: NoRCE: Noncoding RNA Sets Cis Annotation and Enrichment
Version: 1.6.0
Authors@R: c(person("Gulden", "Olgun", 
           email = "gulden@cs.bilkent.edu.tr", 
		   role = c("aut", "cre")))
Description: While some non-coding RNAs (ncRNAs) are assigned  critical regulatory roles, most remain functionally uncharacterized. This presents a challenge whenever an interesting set of ncRNAs needs to be analyzed in a functional context. Transcripts located close-by on the genome are often regulated together. This genomic proximity on the sequence can hint to a functional association. We present a tool, NoRCE, that performs cis enrichment analysis for a given set of ncRNAs. Enrichment is carried out using the functional annotations of the coding genes located proximal to the input ncRNAs. Other biologically relevant information such as topologically associating domain (TAD) boundaries, co-expression patterns, and miRNA target prediction information can be incorporated to conduct a richer enrichment analysis. To this end, NoRCE includes several relevant datasets as part of its data repository, including cell-line specific TAD boundaries, functional gene sets, and expression data for coding & ncRNAs specific to cancer. Additionally, the users can utilize custom data files in their investigation. Enrichment results can be retrieved in a tabular format or visualized in several different ways. NoRCE is currently available for the following species: human, mouse, rat, zebrafish, fruit fly, worm, and yeast.
License: MIT + file LICENSE
Depends: R (>= 4.0)
Imports: KEGGREST,png,dplyr,graphics,RSQLite,DBI,tidyr,grDevices,
        S4Vectors,SummarizedExperiment,reactome.db,rWikiPathways,RCurl,
        dbplyr,utils,ggplot2,igraph,stats,reshape2,readr,
        GO.db,zlibbioc,
        biomaRt,rtracklayer,IRanges,GenomicRanges,GenomicFeatures,AnnotationDbi
Encoding: UTF-8
RoxygenNote: 7.1.1
Suggests: knitr,
        TxDb.Hsapiens.UCSC.hg38.knownGene,TxDb.Drerio.UCSC.danRer10.refGene,
        TxDb.Mmusculus.UCSC.mm10.knownGene,TxDb.Dmelanogaster.UCSC.dm6.ensGene,
        testthat,TxDb.Celegans.UCSC.ce11.refGene,rmarkdown,
        TxDb.Rnorvegicus.UCSC.rn6.refGene,TxDb.Hsapiens.UCSC.hg19.knownGene,
        org.Mm.eg.db,
        org.Rn.eg.db,org.Hs.eg.db,org.Dr.eg.db,BiocGenerics,
        org.Sc.sgd.db, org.Ce.eg.db,org.Dm.eg.db, methods,markdown
VignetteBuilder: knitr
biocViews: BiologicalQuestion, DifferentialExpression,
        GenomeAnnotation, GeneSetEnrichment, GeneTarget,
        GenomeAssembly, GO
LazyData: true
BugReports: https://github.com/guldenolgun/NoRCE/issues
git_url: https://git.bioconductor.org/packages/NoRCE
git_branch: RELEASE_3_14
git_last_commit: 8637123
git_last_commit_date: 2021-11-21
Date/Publication: 2022-01-09
NeedsCompilation: no
Packaged: 2022-01-09 17:37:54 UTC; biocbuild
Author: Gulden Olgun [aut, cre]
Maintainer: Gulden Olgun <gulden@cs.bilkent.edu.tr>
Built: R 4.1.2; ; 2022-01-10 11:31:00 UTC; windows
