splatEstDropout {splatter} | R Documentation

## Estimate Splat dropout parameters

### Description

Estimate the midpoint and shape parameters for the logistic function used when simulating dropout.

### Usage

    splatEstDropout(norm.counts, params)

### Arguments

`norm.counts` | library size normalised counts matrix.
`params` | SplatParams object to store estimated values in.

### Details

Logistic function parameters are estimated by fitting a logistic function to the relationship between log2 mean gene expression and the proportion of zeros in each gene. See `nls` for details of fitting. Note this is done on the experiment level, more granular (eg. group or cell) level dropout is not estimated.

### Value

SplatParams object with estimated values.

[Package splatter version 1.11.4 Index]