lambdaPWM<- {ChIPanalyser} | R Documentation

## Setter Method for the `lambdaPWM` slot in a `parameterOptions` object

### Description

Setter Method for the `lambdaPWM` slot in a `parameterOptions` object

### Usage

    lambdaPWM(object)<-value

### Arguments

`object` | `object` is `parameterOptions` object
`value` | `value` is the numeric value to be assigned to the lambdaPWM slot. Default set at 1.

### Details

The model underlying ChIPanalyser internally infers two paramters: number of bound molecules and lambda. Lambda represents a scaling factor for the Position weight matrix (PWM). This can be described as how well does a TF discriminate between high affinity and very high affinity sites.

### Value

Returns the value assigned to the `lambdaPWM` slot in a `parameterOptions` object.

### Author(s)

Patrick C. N. Martin <p.martin@essex.ac.uk>

### References

Zabet NR, Adryan B (2015) Estimating binding properties of transcription factors from genome-wide binding profiles. Nucleic Acids Res., 43, 84–94.

### Examples

    # Loading data
    data(ChIPanalyserData)

    #Building data objects
    GPP <- parameterOptions(lambdaPWM=1)
    #Setting new Value for lambdaPWM
    lambdaPWM(GPP) <- 2

[Package ChIPanalyser version 1.8.0 Index]