RnBeads 0.99.23
===============

 * incorporated some bioconductor check related improvements

RnBeads 0.99.22
===============

 * Incorporated bioconductor requirements for parallel processing. "parallel.disable" is now "parallel.teardown"

RnBeads 0.99.20
===============

 * RnBeads no longer suggests IlluminaHumanMethylation450k.db.

RnBeads 0.99.19
===============

 * Fixed a bug in the computation of surrogate variables (SVA) that did not take into account other adjustment variables in the model (compared to the null model)
 * Updated locus profiles to work with the latest version of Gviz
 * Differential methylation reports now contain information on group sizes
 * Included plots of number of sites vs coverage percentiles for each sample in the dataset (rnb.plot.num.sites.covg)
 * Bisulfite-seq QC reports now contain an additional section with summary statistics and plots when the coverage histogram plots are enabled

RnBeads 0.99.18
===============

 * Implementation of class constructors (the S4 constructors are not available anymore)
 * Analyses can now be started from an RnBSet which is stored on the hard drive (using save.rnb.set) via the rnb.set.dir data type
 * New IDAT loading routine, based on the illuminaio package
 * Multiple fixes in wrappers for wateRmelon normalization methods
 * Fixed the RefFreeEWAS wrapper
 * Updated the Houseman, 2012 reference-based method implementation
 * RnBSets now know the version with which they were created
 * Various other bugfixes and improvements to reports and documentation

RnBeads 0.99.17
===============

 * Consistency issues with Bioconductor 3.0 fixed
 * Fixed a bug relating to no coverage masking being conducted for sequencing data
 * Various other bugfixes

RnBeads 0.99.16
===============

 * Enhanced XML-based analysis though the tag preanalysis.script
 * Optimized loading of the sequencing data sets
 * Enhanced region profiles plots. Added region site distribution plots 
 * Locus profiles can now be generated in the exploratory report for regions specified in custom bed files and for genes listed as gene symbols
 * Improved cell type heterogeneity inference (no cell types excluded anymore)
 * Added more support for paired differential methylation with limma
 * Some functions were renamed: merge.samples->mergeSamples, add.pheno->addPheno, add.region.subsegments->addRegionSubsegments, and all functions operating on Report
 * Added helper classes for submitting RnBeads to a scientific compute cluster. Current implementation includes Sun Grid Engine
 * The default pipeline now uses ff functionality and saves intermediate objects into the report directory 
 * Minor bugfixes

RnBeads 0.99.15
===============

 * Restructuring of the pipeline modules:
 ** the loading module has been renamed to import
 ** the prefiltering,normalization and postfiltering modules have been summarized in a new module: preprocessing
 ** the batch and profiles modules have been summarized in a new module for exploratory analysis
 ** the export module has been renamed to tracks and tables
 ** corresponding option names have been changed
 ** see the overview figure on the website or the vignette for a quick overview on the new module structure
 * Multiple RnBSets can now be concatenated with the add() function
 * Multiple samples in an RnBSet can be merged using the merge.samples() function
 * Gender prediction can be performed on Infinium 450k datasets
 * Minor updates on covariate adjustment
 * Updates on tissue heterogeneity estimation
 * Calling differentially methylated sites with RefFreeEWAS now supports paired design
 * Multiple minor bugfixes and performance improvements
 * Vignette and documentation updates

RnBeads 0.99.13
===============

 * Added new module on annotation inference
 * Added correction for cell type heterogeneity
 * Added SVA functionality
 * Minor bugfixes
 * Updates to the vignette and other documentation

RnBeads 0.99.12
===============

 * Support Bismark coverage file loading
 * Enhanced documentation and logging of loading steps
 * Minor bugfixes
 * Updates to the vignette and other documentation

 RnBeads 0.99.11
===============

 * Accommodate data packages for individual genomes
 * Performance: disk space usage when using disk dumping, options for subsetting sites when computing distance matrices for clustering, PCA and MDS
 * Region subsegmentation
 * The default method for differential methylation p-values is limma

RnBeads 0.99.10
===============

 * Performance improvements
 * Option to keep big matrices on the hard drive rather than main memory
 * Restructuring of the filtering modules. Parts of the filtering steps are executed before normalization others afterwards
 * Improvements in normalization: more methods supported
 * Cosmetic changes to some of the plots

RnBeads 0.99.9
==============

 * Bugfixes in paired analysis
 * Usability of bisulfite sequencing
 
RnBeads 0.99.8
==============

 * New normalization methods integrated
 * Improved arguments to rnb.run.analysis
 * Improved parsing of the sample annotation table
 * Paired analysis (testing stage)
 * Webservice installed
 * Multiple bugfixes
 
RnBeads 0.99.7
==============

 * Support for background subtraction and BMIQ normalization of Infinium 450k data
 * Support for differential methylation analysis on all pairs of sample groups

RnBeads 0.99.6
==============

 * Locus Profiles
 * Support for parallel computing

RnBeads 0.99.0
==============

 * Many additional features including bisulfite sequencing mode, the mouse genome, data export, ...

RnBeads 0.5.0
=============

 * Initial release of RnBeads containing six modules - loading and normalization, quality control, filtering, batch effects, methylation profiles and differential methylation.
