Package: sSeq
Type: Package
Title: Shrinkage estimation of dispersion in Negative Binomial models
        for RNA-seq experiments with small sample size
Version: 1.0.0
Date: 2013-04-17
Author: Danni Yu <dyu@purdue.edu>, 
        Wolfgang Huber <whuber@embl.de> and 
        Olga Vitek <ovitek@purdue.edu>
Maintainer: Danni Yu <dyu@purdue.edu>
Depends: R (>= 3.0), caTools, RColorBrewer
Description: The purpose of this package is to discover the genes that are 
 differentially expressed between two conditions in RNA-seq experiments. Gene 
 expression is measured in counts of transcripts and modeled with the Negative 
 Binomial (NB) distribution using a shrinkage approach for dispersion 
 estimation. The method of moment (MM) estimates for dispersion are shrunk 
 towards an estimated target, which minimizes the average squared difference 
 between the shrinkage estimates and the initial estimates. The exact per-gene 
 probability under the NB model is calculated, and used to test the hypothesis 
 that the expected expression of a gene in two conditions identically follow a 
 NB distribution.
License: GPL (>= 3)
LazyLoad: yes
Packaged: 2013-10-15 08:22:00 UTC; biocbuild
Built: R 3.0.2; ; 2013-10-15 16:11:41 UTC; windows
