Package: birta
Version: 1.4.0
Date: 2013-03-07
Title: Bayesian Inference of Regulation of Transcriptional Activity
Author: Benedikt Zacher, Khalid Abnaof, Stephan Gade, Erfan Younesi, Achim Tresch, Holger Froehlich
Maintainer: Benedikt Zacher <zacher@lmb.uni-muenchen.de>, Holger
        Froehlich <frohlich@bit.uni-bonn.de>
Depends: limma, MASS, R(>= 2.10), Biobase, methods
Description: Expression levels of mRNA molecules are regulated by different processes, comprising inhibition or activation by transcription factors and post-transcriptional degradation by microRNAs. birta (Bayesian Inference of Regulation of Transcriptional Activity) uses the regulatory networks of TFs and miRNAs together with mRNA and miRNA expression data to predict switches in regulatory activity between two conditions. A Bayesian network is used to model the regulatory structure and Markov-Chain-Monte-Carlo is applied to sample the activity states.
License: GPL (>= 2)
biocViews: Microarray, Sequencing, GeneExpression, Transcription,
        Bioinformatics, GraphsAndNetworks
LazyLoad: yes
Packaged: 2013-04-04 11:06:50 UTC; biocbuild
Built: R 3.0.0; i386-w64-mingw32; 2013-04-04 16:42:13 UTC; windows
Archs: i386, x64
