findTargets {isomiRs} | R Documentation

## Find miRNAs target using mRNA/miRNA expression

### Description

This function creates a matrix with rows (genes) and columns (mirnas) with values indicating if miRNA-gene pair is target according putative targets and negative correlation of the expression of both molecules.

### Usage

    findTargets(mirna_rse, gene_rse, target, summarize = "group",
      min_cor = -0.6)

### Arguments

`mirna_rse` | SummarizedExperiment::SummarizedExperiment with miRNA information. See details.
`gene_rse` | SummarizedExperiment::SummarizedExperiment with gene information. See details.
`target` | Data.frame with two columns: gene and miRNA.
`summarize` | Character column name in colData(rse) to use to group samples and compare betweem miRNA/gene expression.
`min_cor` | Numeric cutoff for correlation value that will be use to consider a miRNA-gene pair as valid.

### Value

mirna-gene matrix

### Examples

    data(isoExample)
    mirna_ma <- data.frame(gene = names(gene_ex_rse)[1:20],
                           mir = names(mirna_ex_rse))
    corMat <- findTargets(mirna_ex_rse, gene_ex_rse, mirna_ma)

[Package isomiRs version 1.8.0 Index]