Package: synergyfinder
Type: Package
Title: Calculate and Visualize Synergy Scores for Drug Combinations
Version: 3.4.5
Date: 2022-10-11
Authors@R: 
  c(person(given = "Shuyu",
           family = "Zheng",
           role = c("aut", "cre"),
           email = "shuyu.zheng@helsinki.fi"
           ),
    person(given = "Jing",
           family = "Tang",
           role = c("aut"),
           email = "jing.tang@helsinki.fi"
           )
    )
Depends: R (>= 4.0.0)
Imports: drc (>= 3.0-1), reshape2 (>= 1.4.4), tidyverse (>= 1.3.0),
        dplyr (>= 1.0.3), tidyr (>= 1.1.2), purrr (>= 0.3.4), furrr (>=
        0.2.2), ggplot2 (>= 3.3.3), ggforce (>= 0.3.2), grid (>=
        4.0.2), vegan (>= 2.5-7), gstat (>= 2.0-6), sp (>= 1.4-5),
        methods (>= 4.0.2), SpatialExtremes (>= 2.0-9), ggrepel (>=
        0.9.1), kriging (>= 1.1), plotly (>= 4.9.3), stringr (>=
        1.4.0), future (>= 1.21.0), mice (>= 3.13.0), lattice (>=
        0.20-41), nleqslv (>= 3.3.2), stats (>= 4.0.2), graphics (>=
        4.0.2), grDevices (>= 4.0.2), magrittr (>= 2.0.1), pbapply (>=
        1.4-3), metR (>= 0.9.1)
Description: Efficient implementations for analyzing pre-clinical multiple drug 
  combination datasets. It provides efficient implementations for 1.the popular
  synergy scoring models, including HSA, Loewe, Bliss, and ZIP to quantify the
  degree of drug combination synergy; 2. higher order drug combination data
  analysis and synergy landscape visualization for unlimited number of drugs in a
  combination; 3. statistical analysis of drug combination synergy and
  sensitivity with confidence intervals and p-values; 4. synergy barometer for
  harmonizing multiple synergy scoring methods to provide a consensus metric of
  synergy; 5. evaluation of synergy and sensitivity simultaneously to provide an
  unbiased interpretation of the clinical potential of the drug combinations.
  Based on this package, we also provide a web application
  (https://synergyfinderplus.org/) for users who prefer graphical user
  interface.
License: Mozilla Public License 2.0
Encoding: UTF-8
URL: https://synergyfinderplus.org/
RoxygenNote: 7.1.2
Suggests: knitr, rmarkdown
VignetteBuilder: knitr
biocViews: Software, StatisticalMethod
git_url: https://git.bioconductor.org/packages/synergyfinder
git_branch: RELEASE_3_15
git_last_commit: a8b8c40
git_last_commit_date: 2022-10-11
Date/Publication: 2022-10-13
NeedsCompilation: no
Packaged: 2022-10-14 01:10:26 UTC; biocbuild
Author: Shuyu Zheng [aut, cre],
  Jing Tang [aut]
Maintainer: Shuyu Zheng <shuyu.zheng@helsinki.fi>
Built: R 4.2.1; ; 2022-10-14 10:29:16 UTC; windows
