rand_query_ES {signatureSearch} | R Documentation

## Generate WTCS Null Distribution with Random Queries

### Description

Function computes null distribution of Weighted Connectivity Scores (WTCS) used by the LINCS GESS method for computing nominal P-values.

### Usage

    rand_query_ES(h5file, N_queries = 1000, dest)

### Arguments

`h5file` | character(1), path to the HDF5 file representing the reference database
`N_queries` | number of random queries
`dest` | path to the output file (e.g. "ES_NULL.txt")

### Value

File with path assigned to `dest`

### References

Subramanian, A., Narayan, R., Corsello, S. M., Peck, D. D., Natoli, T. E., Lu, X., Golub, T. R. (2017). A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. Cell, 171 (6), 1437-1452.e17. URL: https://doi.org/10.1016/j.cell.2017.10.049

### See Also

`gess_lincs`

### Examples

    db_path = system.file("extdata", "sample_db.h5", package="signatureSearch")
    rand_query_ES(h5file=db_path, N_queries=5, dest="ES_NULL.txt")
    unlink("ES_NULL.txt")

[Package signatureSearch version 1.0.4 Index]