fixAge {biscuiteer} | R Documentation

## Turn 'epigenetic clock' into actual age

### Description

Uses Horvath-type 'epigenetic clock' raw output to project into actual ages

### Usage

    fixAge(x, adult = 21)

### Arguments

`x` | Untransformed or raw prediction(s)
`adult` | Age of adulthood (DEFAULT: 21)

### Details

The 'Epigenetic Clock' (Horvath 2012) and similar schemes use a number of CpG loci (or regions, or perhaps CpH loci – it doesn't really matter what) to estimate the chronological/biological age of samples from DNA methylation with pre-trained feature weights (coefficients) for each region/locus.

All of these type of clocks use a nonlinear output transformation which switches from an exponential growth model for children into a linear model for adults, where `adult` is an arbitrary number (by default and custom, that number is 21; elsewhere it can sometimes be seen as 20, but all known epi-age transformation functions quietly add 1 to the constant internally).

This function implements the above standard output transformation step.

### Value

      Transformed prediction(s)

### Examples

      clock <- getClock(genome="hg38")
      score <- clock$gr$score

      age <- fixAge(score)

[Package biscuiteer version 1.0.0 Index]