XBSeq-package {XBSeq} | R Documentation

## Differential expression analysis of RNA sequencing data by incorporating non-exonic mapped reads

### Description

We developed a novel algorithm, XBSeq, where a statistical model was established based on the assumption that observed signals are the convolution of true expression signals and sequencing noises. The mapped reads in non-exonic regions are considered as sequencing noises, which follows a Poisson distribution. Given measureable observed signal and background noise from RNA-seq data, true expression signals, assuming governed by the negative binomial distribution, can be delineated and thus the accurate detection of differential expressed genes.

### Details

Package: | XBSeq
Type: | Package
Version: | 1.1.0
Date: | 2015-12-02
License: | >=GPL3
Imports: | DESeq2, Biobase, pracma, matrixStats, ggplot2,locfit, methods, BiocGenerics, dplyr, plotly, MetricsGraphics

### Author(s)

Yuanhang Liu

Maintainer: Yuanhang Liu <liuy12@uthscsa.edu>

### References

H. I. Chen, Y. Liu, Y. Zou, Z. Lai, D. Sarkar, Y. Huang, et al., "Differential expression analysis of RNA sequencing data by incorporating non-exonic mapped reads," BMC Genomics, vol. 16 Suppl 7, p. S14, Jun 11 2015.

[Package XBSeq version 1.18.0 Index]