heart.metaXcan {GIGSEA} | R Documentation

## heart.metaXcan

### Description

The MetaXcan-predicted differential gene expression from the cardiovascular disease (CVD) GWAS, CARDIoGRAMplusC4D (60,801 cases, 123,504 controls and 9.4M SNPs).

### Usage

    heart.metaXcan

### Format

A data frame with the following items:

gene

  a gene's id

gene_name

  a gene's name

zscore

  MetaXcan's association result for the gene

effect_size

  MetaXcan's association effect size for the gene

pvalue

  P-value of the aforementioned statistic

pred_perf_r2

  R2 of transcriptome prediction model's correlation to gene's measured transcriptome

pred_perf_pval

  pval of transcriptome prediction model's correlation to gene's measured transcriptome

pred_perf_qval

  qval of transcriptome prediction model's correlation to gene's measured transcriptome

n_snps_used

  number of snps from GWAS that got used in MetaXcan analysis

n_snps_in_cov

  number of snps in the covariance matrix

n_snps_in_model

  number of snps in the prediction model

var_g

  variance of the gene expression

...

### Source

http://www.cardiogramplusc4d.org/data-downloads/;https://cloud.hakyimlab.org/s-predixcan

[Package GIGSEA version 1.4.0 Index]