DoMetaEfron {EpiDISH} | R Documentation

## An R-function to perform a meta-analysis over multiple studies using an empirical Bayes procedure by Efron followed by Stouffer method.

### Description

An R-function to perform a meta-analysis over multiple studies using an empirical Bayes procedure by Efron followed by Stouffer method.

### Usage

    DoMetaEfron(stat.m, pval.m, bre = 120, df = 15, pct0 = 0.25, plotlocfdr = 0)

### Arguments

`stat.m` | A matrix of signed statistics (e.g. t-statistics) with rows labeling genomic features (e.g. CpGs or genes) and columns labeling studies. rownames must be provided.
`pval.m` | A matrix matched to stat.m containing the associated P-values, with rows labeling genomic features (e.g. CpGs or genes) and columns labeling studies.
`bre` | The number of breakpoints to divide statistics per study into bins. By default this is 120. See input argument for locfdr function from locfdr package.
`df` | The number of degrees of freedom for fitting spline. By default this is 15. See input argument for locfdr function from locfdr package.
`pct0` | Percentage of statistics to use for fitting null. By default this is 0.25 (i.e. 25%).
`plotlocfdr` | Determines whether to plot output or not. By default this is set to 0 meaning no plot. See input argument for locfdr function from locfdr package.

### Value

meta.m A matrix with rows as in stat.m, and with 3 columns labeling Stouffer's z-statistic, P-value and Benjamini-Hochberg adjusted P-value.

[Package EpiDISH version 2.2.2 Index]