lying.tunell.data {BiGGR} | R Documentation

## Dataset of in vivo cerebral metabolite uptake and release rates in healthy humans (old subjects)

### Description

These data were taken from a publication of Lying-Tunell et al. (1980) reporting cerebral metabolic uptakes and release rates in older subjects (n=5). The data were published as micromole/kg/min, but converted to mmole/min for this dataset (see details).

### Usage

    data(lying.tunell.data)

### Format

An object of class data.frame

### Details

Data were taken from table 2 (page 271) of the publication. From the given median and range values, mean and standard deviation was estimated using a method by Hozo et al. (2005). Units were converted from micromole/kg/min to mmole/min assuming a brain mass of 1.4kg.

### Source

http://www.ncbi.nlm.nih.gov/pubmed/7468149

### References

Lying-Tunell U, Lindblad BS, Malmlund HO, Persson B: Cerebral blood flow and metabolic rate of oxygen, glucose, lactate, pyruvate, ketone bodies and amino acids. Acta Neurol Scand 1980, 62:265-75.

Hozo SP, Djulbegovic B, Hozo I: Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 2005, 5:13.

### Examples

    ## Not run:
    ##The dataset was generated as follows:

    ##Uptake rates given in micromole/kg/min from Lying-Tunell (1980), n=5 old patients
    ##converted to mmol/min and assuming a brain mass of 1.4 kg
    brain.mass <- 1.4 ## in kg
    oxygen.median <- 1679 * brain.mass / 1000
    oxygen.range <- c(1184, 1872) * brain.mass / 1000
    glucose.median <- 203 * brain.mass / 1000
    glucose.range <- c(187, 321) * brain.mass / 1000
    lactate.median <- -9.2 * brain.mass / 1000
    lactate.range <- c(-68, 7.9) * brain.mass / 1000
    pyruvate.median <- -2.4 * brain.mass / 1000
    pyruvate.range <- c(-10, -brain.mass) * brain.mass / 1000
    glutamine.median <- -11 * brain.mass / 1000
    glutamine.range <- c(-61, 22) * brain.mass / 1000

    ##This implements eq 4 from Hozo et al. to estimate
    ##sample mean from median and range
    ##m: median, a: minimum, b: maximum, n: number of samples
    estimate.sample.mean <- function(m, a, b, n)
    (a + 2*m + b)/4 + (a-2*m + b)/(4*n)

    ##This implements eq 16 from Hozo et al. to estimate
    ##sample standard deviation from median and range
    ##m: median, a: minimum, b: maximum, n: number of samples
    estimate.sample.sd <- function(m, a, b, n)
    sqrt((((a - 2*m + b)^2)/4 + (b-a)^2)/12)

    ##Calculate mean and standard deviation from median and range values using the method of Hoxo et al.
    oxygen.mean <- estimate.sample.mean(oxygen.median, oxygen.range[1], oxygen.range[2], 5)
    oxygen.sd <- estimate.sample.sd(oxygen.median, oxygen.range[1], oxygen.range[2], 5)

    glucose.mean <- estimate.sample.mean(glucose.median, glucose.range[1], glucose.range[2], 5)
    glucose.sd <- estimate.sample.sd(glucose.median, glucose.range[1], glucose.range[2], 5)

    lactate.mean <- estimate.sample.mean(lactate.median, lactate.range[1], lactate.range[2], 5)
    lactate.sd <- estimate.sample.sd(lactate.median, lactate.range[1], lactate.range[2], 5)

    pyruvate.mean <- estimate.sample.mean(pyruvate.median, pyruvate.range[1], pyruvate.range[2], 5)
    pyruvate.sd <- estimate.sample.sd(pyruvate.median, pyruvate.range[1], pyruvate.range[2], 5)

    glutamine.mean <- estimate.sample.mean(glutamine.median, glutamine.range[1], glutamine.range[2], 5)
    glutamine.sd <- estimate.sample.sd(glutamine.median, glutamine.range[1], glutamine.range[2], 5)

    lying.tunell.data <- data.frame(median=c(oxygen.median, glucose.median, lactate.median, pyruvate.median, glutamine.median),
    							mean=c(oxygen.mean, glucose.mean, lactate.mean, pyruvate.mean, glutamine.mean),
    							sd=c(oxygen.sd, glucose.sd, lactate.sd, pyruvate.sd, glutamine.sd),
    							low=c(oxygen.range[1], glucose.range[1], lactate.range[1], pyruvate.range[1], glutamine.range[1]),
    							high=c(oxygen.range[2], glucose.range[2], lactate.range[2], pyruvate.range[2], glutamine.range[2]),
    							row.names=c("o2", "glucose", "lactate", "pyruvate", "glutamine"))

    ## End(Not run)

    ##load data
    data(lying.tunell.data)
    ##get median value for glucose uptake
    lying.tunell.data["glucose", "median"]

[Package BiGGR version 1.22.0 Index]