Package: CGHnormaliter
Type: Package
Title: Normalization of array CGH data with imbalanced aberrations.
Version: 1.0.1
Date: 2009-10-05
Author: Thomas W. Binsl, Bart P.P. van Houte, Hannes Hettling
Maintainer: Bart P.P. van Houte <bvhoute@few.vu.nl>
Depends: CGHcall (>= 2.2.0), CGHbase (>= 1.2.0)
Imports: Biobase, CGHbase, CGHcall, methods, stats, utils
Description: CGHnormaliter is an iterative algorithm for normalization
        of aCGH data displaying imbalanced aberrations. First,
        provisory balanced copy numbers are identified and subsequently
        used for normalization based on LOWESS. These two steps are
        then iterated to refine the normalization. The assumption here
        is that the temporary exclusion of aberrations allows for a
        more appropriate calculation of the LOWESS regression curve. As
        a result, after normalization, the log2 intensity ratios of the
        normals will generally be closer to zero and better reflect the
        biological reality.
License: GPL (>= 3)
biocViews: Microarray, DNACopyNumber, Preprocessing
Packaged: 2010-03-02 11:08:53 UTC; biocbuild
Built: R 2.10.1; ; 2010-03-02 15:05:36 UTC; windows
