CGHregions-package        package:CGHregions        R Documentation

_D_i_m_e_n_s_i_o_n _R_e_d_u_c_t_i_o_n _f_o_r _A_r_r_a_y _C_G_H _D_a_t_a _w_i_t_h _M_i_n_i_m_a_l _I_n_f_o_r_m_a_t_i_o_n _L_o_s_s.

_D_e_s_c_r_i_p_t_i_o_n:

     CGHregions takes as input array CGH data (log2-ratios) that have
     been segmented (i.e., split into chromosomal segments of similar
     log2-ratios) and called (i.e., a copy number assigned to each
     segment) on a per-sample basis and adjusts the segmentation so
     that break-points that are in similar locations across multiple
     samples are set to be in identical locations. Segmented and called
     data can be obtained by using the CGHcall package. The resulting
     dimensionality reduction facilitates downstream analysis in a
     variety of ways (e.g., reduces severity of multiple hypothesis
     testing, facilitates clustering and visualization, reduces
     computer memory requirements).

_D_e_t_a_i_l_s:


       Package:  CGHregions
       Type:     Package
       Version:  0.99.0
       Date:     2008-04-29
       License:  GPL

_A_u_t_h_o_r(_s):

     Mark van de Wiel and Sjoerd Vosse Maintainer: Mark van de Wiel
     <mark.vdwiel@vumc.nl>

_R_e_f_e_r_e_n_c_e_s:

     Mark A. van de Wiel and Wessel N. van Wieringen (2007).
     CGHregions: Dimension Reduction for Array CGH Data with Minimal
     Information Loss. _Cancer Informatics, 2_, 55-63.

